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. 1973 Sep;15(1):27–34.

Lymphocyte transforamtion and leucocyte migration–inhibition by Australia antigen

A A C Yeung Laiwah, A K R Chaudhuri, J R Anderson
PMCID: PMC1553856  PMID: 4765719

Abstract

The occurrence of a state of cell-mediated immune responsiveness to the Australia antigen following acute virus-B hepatitis has been demonstrated by the use of two in vitro methods—the lymphocyte transformation test and the leucocyte migration–inhibition test. Australia antigen-rich serum and purified Australia antigen were found to be effective agents in both tests. Close correlation was observed between the two tests. Persistent carriers of the Australia antigen give negative results with both tests.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Almeida J. D., Waterson A. P. Immune complexes in hepatitis. Lancet. 1969 Nov 8;2(7628):983–986. doi: 10.1016/s0140-6736(69)90540-6. [DOI] [PubMed] [Google Scholar]
  2. Anthony P. P., Vogel C. L., Sadikali F., Barker L. F., Peterson M. R. Hepatitis-associated antigen and antibody in Uganda: correlation of serological testing with histopathology. Br Med J. 1972 Feb 12;1(5797):403–406. doi: 10.1136/bmj.1.5797.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blumberg B. S., Melartin L. Australia antigen and hepatitis. Studies in asymptomatic people and lepromatous leprosy patient. Arch Intern Med. 1970 Feb;125(2):287–292. doi: 10.1001/archinte.125.2.287. [DOI] [PubMed] [Google Scholar]
  4. Dudley F. J., Fox R. A., Sherlock S. Cellular immunity and hepatitis-associated, Australia antigen liver disease. Lancet. 1972 Apr 1;1(7753):723–726. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
  5. Gerstley B. J., Custer R. P., Blumberg B. S., London W. T., Sutnick A. I., Coyne V. Z. Liver biopsies in patients with and without Australia antigen. Arch Pathol. 1972 Apr;93(4):366–371. [PubMed] [Google Scholar]
  6. Laiwah A. A. Lymphocyte transformation by Australia antigen. Lancet. 1971 Aug 28;2(7722):470–471. doi: 10.1016/s0140-6736(71)92633-x. [DOI] [PubMed] [Google Scholar]
  7. Lander H. J., Holland P. V., Alter H. J., Chanock R. M., Purcell R. H. Antibody to hepatitis-associated antigen. Frequency and pattern of response as detected by radioimmunoprecipitation. JAMA. 1972 May 22;220(8):1079–1082. doi: 10.1001/jama.220.8.1079. [DOI] [PubMed] [Google Scholar]
  8. London W. T., Di Figlia M., Sutnick A., Blumberg B. S. An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med. 1969 Sep 11;281(11):571–578. doi: 10.1056/NEJM196909112811101. [DOI] [PubMed] [Google Scholar]
  9. Nielsen J. O., Dietrichson O., Elling P., Christoffersen P. Incidence and meaning of persistence of Australia antigen in patients with acute viral hepatitis: development of chronic hepatitis. N Engl J Med. 1971 Nov 18;285(21):1157–1160. doi: 10.1056/NEJM197111182852101. [DOI] [PubMed] [Google Scholar]
  10. Popper H., Mackay I. R. Relation between Australia antigen and autoimmune hepatitis. Lancet. 1972 May 27;1(7761):1161–1164. doi: 10.1016/s0140-6736(72)91379-7. [DOI] [PubMed] [Google Scholar]
  11. Prince A. M. An antigen detected in the blood during the incubation period of serum hepatitis. Proc Natl Acad Sci U S A. 1968 Jul;60(3):814–821. doi: 10.1073/pnas.60.3.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reinicke V., Dybkjaer E., Poulsen H., Banke O., Lylloff K., Nordenfelt E. A study of Australia-antigen-positive blood donors and their recipients, with special reference to liver histology. N Engl J Med. 1972 Apr 20;286(16):867–870. doi: 10.1056/NEJM197204202861604. [DOI] [PubMed] [Google Scholar]
  13. Rocklin R. E., Meyers O. L., David J. R. An in vitro assay for cellular hypersensitivity in man. J Immunol. 1970 Jan;104(1):95–102. [PubMed] [Google Scholar]
  14. Sherlock S., Fox R. A., Niazi S. P., Scheuer P. J. Chronic liver disease and primary liver-cell cancer with hepatitis-associated (Australia) antigen in serum. Lancet. 1970 Jun 13;1(7659):1243–1247. doi: 10.1016/s0140-6736(70)91737-x. [DOI] [PubMed] [Google Scholar]
  15. Singleton J. W., Merrill D. A., Fitch R. A., Kohler P. F., Rettberg W. A. Liver disease in Australia-antigen-positive blood-donors. Lancet. 1971 Oct 9;2(7728):785–787. doi: 10.1016/s0140-6736(71)92740-1. [DOI] [PubMed] [Google Scholar]
  16. Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]
  17. Thor D. E., Jureziz R. E., Veach S. R., Miller E., Dray S. Cell migration inhibition factor released by antigen from human peripheral lymphocytes. Nature. 1968 Aug 17;219(5155):755–757. doi: 10.1038/219755a0. [DOI] [PubMed] [Google Scholar]
  18. Vogel C. L., Anthony P. P., Mody N., Barker L. F. Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet. 1970 Sep 26;2(7674):621–624. doi: 10.1016/s0140-6736(70)91396-6. [DOI] [PubMed] [Google Scholar]
  19. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]

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