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. 1974 Mar;16(3):401–412.

Immunoglobulins in tracheo-bronchial secretion with special reference to IgE

H Deuschl, S G O Johansson
PMCID: PMC1553937  PMID: 4468847

Abstract

Quantitative measurements of immunoglobulins E, A and G were made in tracheobronchial secretion and serum of thirty-four patients in association with bronchoscopy. Measurable quantities of all three immunoglobulins were found in both secretion and serum in all patients, except in one person, in whom IgA was found neither in the secretion nor the serum, and in another person in whom no measurable IgG was found in the secretion.

Calculations indicated that all immunoglobulins were produced locally in the tracheo-bronchial mucosa. This applied especially to IgA and IgE, of which 84 and 73% respectively, were calculated to have been produced locally.

Quantitative differences between the three immunoglobulins were also apparent between different groups of patients. The number of patients studied is too small, however, for definite conclusions to be drawn in this respect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANZAI T., IBAYASHI J., CARPENTER C. M., HYDE L. BETA-2A-GLOBULIN AS A MOLECULAR CONSTITUENT OF INSOLUBLE BRONCHIAL MUCUS GEL. Am Rev Respir Dis. 1963 Oct;88:503–508. doi: 10.1164/arrd.1963.88.4.503. [DOI] [PubMed] [Google Scholar]
  2. BISERTE G., HAVEZ R., CUVELIER R. LES GLYCOPROT'EIDES DES S'ECR'ETIONS BRONCHIQUES. Expos Annu Biochim Med. 1963;24:85–120. [PubMed] [Google Scholar]
  3. Berg T., Johansson S. G. IgE concentrations in children with atopic diseases. A clinical study. Int Arch Allergy Appl Immunol. 1969;36(3):219–232. doi: 10.1159/000230745. [DOI] [PubMed] [Google Scholar]
  4. DENNIS E. G., HORNBROOK M. M., ISHIZAKA K. SERUM PROTEINS IN SPUTUM OF PATIENTS WITH ASTHMA. J Allergy. 1964 Sep-Oct;35:464–471. doi: 10.1016/0021-8707(64)90072-3. [DOI] [PubMed] [Google Scholar]
  5. Donovan R., Johansson S. G., Bennich H., Soothill J. F. Immunoglobulins in nasal polyp fluid. Int Arch Allergy Appl Immunol. 1970;37(2):154–166. doi: 10.1159/000230229. [DOI] [PubMed] [Google Scholar]
  6. Falk G. A., Okinaka A. J., Siskind G. W. Immunoglobulins in the bronchial washings of patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1972 Jan;105(1):14–21. doi: 10.1164/arrd.1972.105.1.14. [DOI] [PubMed] [Google Scholar]
  7. Ishizaka K., Ishizaka T., Hornbrook M. M. Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth gamma-E-globulin antibody. J Immunol. 1966 Dec;97(6):840–853. [PubMed] [Google Scholar]
  8. Ishizaka K., Newcomb R. W. Presence of gammaE in nasal washings and sputum from asthmatic patients. J Allergy. 1970 Oct;46(4):197–204. doi: 10.1016/0021-8707(70)90023-7. [DOI] [PubMed] [Google Scholar]
  9. Johansson S. G., Bennich H., Wide L. A new class of immunoglobulin in human serum. Immunology. 1968 Feb;14(2):265–272. [PMC free article] [PubMed] [Google Scholar]
  10. Johansson S. G., Högman C. F., Killander J. Quantitative immunoglobulin determination. Comparison of two methods. Estimation of normal levels and levels in persons lacking IgA and IgD. Acta Pathol Microbiol Scand. 1968;74(4):519–530. [PubMed] [Google Scholar]
  11. Johansson S. G. Raised levels of a new immunoglobulin class (IgND) in asthma. Lancet. 1967 Nov 4;2(7523):951–953. doi: 10.1016/s0140-6736(67)90792-1. [DOI] [PubMed] [Google Scholar]
  12. KEIMOWITZ R. I. IMMUNOGLOBULINS IN NORMAL HUMAN TRACHEOBRONCHIAL WASHINGS: A QUALITATIVE AND QUANTITATIVE STUDY. J Lab Clin Med. 1964 Jan;63:54–59. [PubMed] [Google Scholar]
  13. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  14. Masson P. L., Heremans J. F., Prignot J. Studies on the proteins of human bronchial secretions. Biochim Biophys Acta. 1965 Dec 16;111(2):466–478. doi: 10.1016/0304-4165(65)90056-5. [DOI] [PubMed] [Google Scholar]
  15. Newcomb R. W., Ishizaka K. Physicochemical and antigenic studies on human gamma E in respiratory fluid. J Immunol. 1970 Jul;105(1):85–89. [PubMed] [Google Scholar]

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