Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
letter
. 1974 Mar;16(3):497–502.

Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis

D A Rajapakse, E G L Bywaters
PMCID: PMC1553938  PMID: 4283279

Abstract

The presence of cell-mediated immunity and the concurrent absence of humoral immunity to human cartilage proteoglycan are demonstrated in two cases of relapsing polychondritis compared with nine control subjects with other rheumatic diseases. Two in vitro tests have been applied to study each type of immunity.

Full text

PDF
497

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Church R. E. Relapsing polychondritis. Proc R Soc Med. 1971 Dec;64(12):1194–1195. [PMC free article] [PubMed] [Google Scholar]
  2. DAVIES G. E. Prospects for animal tests in experimental sensitization to drugs. Proc R Soc Med. 1962 Jan;55:11–14. [PMC free article] [PubMed] [Google Scholar]
  3. Dolan D. L., Lemmon G. B., Jr, Teitelbaum S. L. Relapsing polychondritis. Analytical literature review and studies on pathogenesis. Am J Med. 1966 Aug;41(2):285–299. doi: 10.1016/0002-9343(66)90023-4. [DOI] [PubMed] [Google Scholar]
  4. Herman J. H., Dennis M. V. Immunopathologic studies in relapsing polychondritis. J Clin Invest. 1973 Mar;52(3):549–558. doi: 10.1172/JCI107215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hughes R. A., Berry C. L., Seifert M., Lessof M. H. Relapsing polychondritis. Three cases with a clinico-pathological study and literature review. Q J Med. 1972 Jul;41(163):363–380. [PubMed] [Google Scholar]
  6. JENSEN F. Polychondritis. Report of the first Danish case. Acta Otolaryngol. 1962 May;54:423–430. doi: 10.3109/00016486209126961. [DOI] [PubMed] [Google Scholar]
  7. Menkes C. J., Siaud J. R., Delrieu F., Chouraki L., Bellaiche D., Delbarre F. Polychondrite chronique atrophiante: deux cas dont l'un avec cataracte et artérite des membres inférieurs. Ann Med Interne (Paris) 1970 Nov;121(11):895–904. [PubMed] [Google Scholar]
  8. Moskowitz R. W., Schwartz H. J., Michel B., Ratnoff O. D., Astrup T. Generation of kinin-like agents by chondroitin sulfate, heparin, chitin sulfate, and human articular cartilage: possible pathophysiologic implications. J Lab Clin Med. 1970 Nov;76(5):790–798. [PubMed] [Google Scholar]
  9. PEARSON C. M., KLINE H. M., NEWCOMER V. D. Relapsing polychondritis. N Engl J Med. 1960 Jul 14;263:51–58. doi: 10.1056/NEJM196007142630201. [DOI] [PubMed] [Google Scholar]
  10. QUINN R. W., CERRONI R. Antigenicity of chondroitin sulfate. Proc Soc Exp Biol Med. 1957 Oct;96(1):268–269. doi: 10.3181/00379727-96-23451. [DOI] [PubMed] [Google Scholar]
  11. Rajapakse D. A., Glynn L. E. Macrophage migration inhibition test using guinea-pig macrophages and human lymphocytes. Nature. 1970 May 30;226(5248):857–858. doi: 10.1038/226857a0. [DOI] [PubMed] [Google Scholar]
  12. THOMAS L., McCLUSKEY R. T., POTTER J. L., WEISSMANN G. Comparison of the effects of papain n vitamin A on cartilage. I. The effects in rabbits. J Exp Med. 1960 May 1;111:705–718. doi: 10.1084/jem.111.5.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. VERITY M. A., LARSON W. M., MADDEN S. C. Relapsing polychondritis. Report of two necropsied cases with histochemical investigation of the cartilage lesion. Am J Pathol. 1963 Mar;42:251–269. [PMC free article] [PubMed] [Google Scholar]
  14. ZIFF M., GRIBETZ H. J., LOSPALLUTO J. Effect of leukocyte and synovial membrane extracts on cartilage mucoprotein. J Clin Invest. 1960 Feb;39:405–412. doi: 10.1172/JCI104051. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES