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. 1974 Mar;16(3):413–417.

Nature of the antigen present in the cerebrospinal fluid and serum of patients with group A meningococcal meningitis

B M Greenwood, H C Whittle
PMCID: PMC1553940  PMID: 4219838

Abstract

The antigen detectable by counter-current immunoelectrophoresis in the cerebrospinal fluid and sera of patients with group A meningococcal meningitis was found to be a high molecular weight polysaccharide. Its composition was deduced from its immunochemical identity with a known group A meningococcal polysaccharide which has previously been shown to be a polymer of N-acetyl, O-acetyl mannosamine phosphate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander H. E. PROGNOSTIC VALUE OF THE PRECIPITIN TEST IN MENINGOCOCCUS MENINGITIS. J Clin Invest. 1937 Mar;16(2):207–211. doi: 10.1172/JCI100849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coonrod J. D., Rytel M. W. Determination of aetiology of bacterial meningitis by counter-immunoelectrophoresis. Lancet. 1972 May 27;1(7761):1154–1157. doi: 10.1016/s0140-6736(72)91376-1. [DOI] [PubMed] [Google Scholar]
  3. Edwards E. A. Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia. J Immunol. 1971 Feb;106(2):314–317. [PubMed] [Google Scholar]
  4. Edwards E. A., Muehl P. M., Peckinpaugh R. O. Diagnosis of bacterial meningitis by counterimmunoelectrophoresis. J Lab Clin Med. 1972 Sep;80(3):449–454. [PubMed] [Google Scholar]
  5. Gotschlich E. C., Liu T. Y., Artenstein M. S. Human immunity to the meningococcus. 3. Preparation and immunochemical properties of the group A, group B, and group C meningococcal polysaccharides. J Exp Med. 1969 Jun 1;129(6):1349–1365. doi: 10.1084/jem.129.6.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Greenwood B. M., Whittle H. C., Bryceson A. D. Allergic complications of meningococcal disease. II. Immunological investigations. Br Med J. 1973 Jun 30;2(5869):737–740. doi: 10.1136/bmj.2.5869.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Greenwood B. M., Whittle H. C., Dominic-Rajkovic O. Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections. Lancet. 1971 Sep 4;2(7723):519–521. doi: 10.1016/s0140-6736(71)90439-9. [DOI] [PubMed] [Google Scholar]
  8. Liu T. Y., Gotschlich E. C., Jonssen E. K., Wysocki J. R. Studies on the meningococcal polysaccharides. I. Composition and chemical properties of the group A polysaccharide. J Biol Chem. 1971 May 10;246(9):2849–2858. [PubMed] [Google Scholar]
  9. Tobin B. M., Jones D. M. Immunoelectroosmophoresis in the diagnosis of meningococcal infections. J Clin Pathol. 1972 Jul;25(7):583–585. doi: 10.1136/jcp.25.7.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Whittle H. C., Abdullahi M. T., Fakunle F. A., Greenwood B. M., Bryceson A. D., Parry E. H., Turk J. L. Allertic complications of meningococcal disease. I. Clinical aspects. Br Med J. 1973 Jun 30;2(5869):733–737. doi: 10.1136/bmj.2.5869.733. [DOI] [PMC free article] [PubMed] [Google Scholar]

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