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. 1974 Mar;16(3):481–492.

Sequential cell-mediated immune responses in experimental gingivitis in man

T Lehner, J M A Wilton, S J Challacombe, L Ivanyi
PMCID: PMC1553956  PMID: 4219840

Abstract

Sequential changes in cell-mediated immune responses were examined in ten young healthy subjects who abstained from routine oral hygiene measures for 28 days. Accumulation of bacterial plaque on the teeth and the associated gingival inflammation were correlated with an increase in lymphocyte transformation and macrophage migration inhibition reactions to sonicates of autologous bacterial plaque, a number of Gram-negative endotoxin-containing organisms, Actinomyces viscosus, and Lactobacillus acidophilus. A biphasic response in lymphocyte transformation was found with two peaks at day 14 and day 28 to day 35, and this was also found with purified protein derivative.

Both cellular responses were of limited duration and had reached baseline values by day 56. The results suggest that a focus of commensal organisms might act as an adjuvant, enhancing both related and unrelated cell-mediated immune responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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