Abstract
`One-way' mixed lymphocyte reactions between fresh, normal, peripheral blood lymphocytes of human or baboon and irradiated or mitomycin C-treated cultured `leukaemic' T lymphoid cells (MOLT-4) were absent in all of forty-six experiments. In contrast, the lymphocytes from the same donors were significantly stimulated by cultured normal B lymphoid cells (B411-4) or Burkitt's lymphoma B lymphoid cells (B35M) in each instance. Neuraminidase-treated MOLT-4 cells also exerted no stimulating effect on allogeneic lymphocytes. Lack of stimulating effect of MOLT-4 cells suggests the possibility that the MLR-S of leukaemic cells may have been lost or masked during the process of leukaemogenesis or during in vitro cultivation.
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