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. 1974 Apr;16(4):535–540.

Lymphocytes bearing complement receptors, surface immunoglobulins and sheep erythrocyte receptors in primary immunodeficiency diseases

J R Luckasen, A Sabad, K J Gajl-Peczalska, J H Kersey
PMCID: PMC1554008  PMID: 4478764

Abstract

Nine patients with primary immunodeficiency diseases were studied for the presence of lymphocytes bearing surface immunoglobulins, complement receptors, and sheep erythrocyte receptors. All were found to have a normal or increased percentage of lymphocytes bearing complement receptors, often despite a deficiency of immunoglobulin-bearing lymphocytes. The results suggest that these patients have a deficiency of surface immunoglobulin synthesis but are not deficient in B lymphocytes. Unsensitized sheep erythrocyte (E) binding (T) lymphocytes were normal or decreased; the sum of E-binding (T) plus complement receptor-bearing (B) lymphocytes was generally within the normal range. One exception was a patient with combined system immunodeficiency who had a decreased total of T plus B lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C. Unresponsiveness to self antigens. Lancet. 1971 Dec 25;2(7739):1401–1403. doi: 10.1016/s0140-6736(71)90673-8. [DOI] [PubMed] [Google Scholar]
  2. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dickler H. B., Kunkel H. G. Interaction of aggregated -globulin with B lymphocytes. J Exp Med. 1972 Jul 1;136(1):191–196. doi: 10.1084/jem.136.1.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gajl-Peczalska K. J., Park B. H., Biggar W. D., Good R. A. B and T lymphocytes in primary immunodeficiency disease in man. J Clin Invest. 1973 Apr;52(4):919–928. doi: 10.1172/JCI107257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Geha R. S., Rosen F. S., Merler E. Identification and characterization of subpopulations of lymphocytes in human peripheral blood after fractionation on discontinuous gradients of albumin. The cellular defect in X-linked agammaglobulinemia. J Clin Invest. 1973 Jul;52(7):1726–1734. doi: 10.1172/JCI107354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lay W. H., Nussenzweig V. Receptors for complement of leukocytes. J Exp Med. 1968 Nov 1;128(5):991–1009. doi: 10.1084/jem.128.5.991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pernis B., Forni L., Amante L. Immunoglobulin spots on the surface of rabbit lymphocytes. J Exp Med. 1970 Nov;132(5):1001–1018. doi: 10.1084/jem.132.5.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Raff M. C., Sternberg M., Taylor R. B. Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature. 1970 Feb 7;225(5232):553–554. doi: 10.1038/225553a0. [DOI] [PubMed] [Google Scholar]
  10. Ross G. D., Rabellino E. M., Polley M. J., Grey H. M. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes. J Clin Invest. 1973 Feb;52(2):377–385. doi: 10.1172/JCI107194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shevach E. M., Herberman R., Frank M. M., Green I. Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines. J Clin Invest. 1972 Aug;51(8):1933–1938. doi: 10.1172/JCI106999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Uhr J. W., Möller G. Regulatory effect of antibody on the immune response. Adv Immunol. 1968;8:81–127. doi: 10.1016/s0065-2776(08)60465-4. [DOI] [PubMed] [Google Scholar]
  13. Wybran J., Fudenberg H. H. Rosette formation, a test for cellular immunity. Trans Assoc Am Physicians. 1971;84:239–247. [PubMed] [Google Scholar]
  14. Yata J., Tsukimoto I. Maturation of cell-surface structure of human B lymphocytes. Lancet. 1972 Dec 30;2(7792):1425–1425. doi: 10.1016/s0140-6736(72)93005-x. [DOI] [PubMed] [Google Scholar]

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