Abstract
Sera from 207 male and 190 female blood donors were studied for spermatozoal antibodies by sperm agglutination and indirect IFT on methanol-fixed spermatozoa.
Sperm agglutinins occurred significantly more frequently in men (about 4%) than in women (0·5%), and IFT (with serum diluted 1:10) revealed a similar relation for antibodies against the main tail piece (about 10% in males vs about 3% in females). Antibodies against the front part of the acrosome and against the equatorial segment were, on the other hand, found with the same frequency in men and women, i.e. in 6–7% and 2–3%, respectively.
Antibodies against the front part of the acrosome were predominantly of the IgM class, while staining of the equatorial segment and the main tail piece was mainly caused by IgG antibodies.
The rare occurrence of sperm agglutinins in women may possibly be a consequence of rapid destruction of the corresponding sperm-specific antigens after ejaculation of the spermatozoa. The identical findings in men and women for antibodies against the acrosomal antigens lead to the suggestion that constitutional factors could be of particular importance for the ability to respond to these antigens.
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Selected References
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- Boettcher B., Hay J., Kay D. J., Baldo B. A., Roberts T. K. Spermagglutinating activity in some human sera. Int J Fertil. 1970 Jul-Sep;15(3):143–158. [PubMed] [Google Scholar]
- FRANKLIN R. R., DUKES C. D. ANTISPERMATOZOAL ANTIBODY AND UNEXPLAINED INFERTILITY. Am J Obstet Gynecol. 1964 May 1;89:6–9. doi: 10.1016/s0002-9378(16)35035-9. [DOI] [PubMed] [Google Scholar]
- Hansen K. B. Immunofluorescent studies on human spermatozoa. 3. Immunoglobulin classes of human spermatozoal antibodies. Clin Exp Immunol. 1972 Feb;10(2):243–249. [PMC free article] [PubMed] [Google Scholar]
- Hjort T., Hansen K. B. Immunofluorescent studies on human spermatozoa. I. The detection of different spermatozoal antibodies and their occurrence in normal and infertile women. Clin Exp Immunol. 1971 Jan;8(1):9–23. [PMC free article] [PubMed] [Google Scholar]
- Isojima S., Tsuchiya K., Koyama K., Tanaka C., Naka O., Adachi H. Further studies on sperm-immobilizing antibody found in sera of unexplained cases of sterility in women. Am J Obstet Gynecol. 1972 Jan 15;112(2):199–207. doi: 10.1016/0002-9378(72)90116-0. [DOI] [PubMed] [Google Scholar]
- KIBRICK S., BELDING D. L., MERRILL B. Methods for the detection of antibodies against mammalian spermatozoa. II. A gelatin agglutination test. Fertil Steril. 1952 Sep-Oct;3(5):430–438. doi: 10.1016/s0015-0282(16)31026-3. [DOI] [PubMed] [Google Scholar]
- RUMKE P., HELLINGA G. Autoantibodies against spermatozoa in sterile men. Am J Clin Pathol. 1959 Oct;32:357–363. doi: 10.1093/ajcp/32.4.357. [DOI] [PubMed] [Google Scholar]
- STRAUS E. K. SPERM IMMOBILIZATION IN THE HUMAN VAGINA BY INDUCED MUCOANTIBODY. Fertil Steril. 1965 May-Jun;16:346–355. doi: 10.1016/s0015-0282(16)35588-1. [DOI] [PubMed] [Google Scholar]
- Schwimmer W. B., Ustay K. A., Behrman S. J. An evaluation of immunologic factors of infertility. Fertil Steril. 1967 Mar-Apr;18(2):167–180. doi: 10.1016/s0015-0282(16)36241-0. [DOI] [PubMed] [Google Scholar]