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. 1991 Oct;86(1):56–60. doi: 10.1111/j.1365-2249.1991.tb05773.x

T cell responses to synthetic thyroid peroxidase peptides in autoimmune thyroid disease.

N Tandon 1, M Freeman 1, A P Weetman 1
PMCID: PMC1554152  PMID: 1717189

Abstract

Sixteen peptides, representing four different extracellular regions of thyroid peroxidase (TPO) predicted to contain a high proportion of potential T cell epitopes, were synthesized to investigate which parts of this autoantigen may be targets for the T cell response in thyroid autoimmunity. Compared with 25 controls, peripheral blood T cells from 23-37% of 30 patients with Graves' disease or autoimmune hypothyroidism were stimulated significantly by three peptides, representing amino acids 415-432, 439-457 and 463-481 of the TPO sequence; T cells from individual patients were also stimulated by several other peptides. These results indicate that the T cell response to TPO is directed against several epitopes which may be recognized by different patients.

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Selected References

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