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. 1991 Dec;86(3):520–524. doi: 10.1111/j.1365-2249.1991.tb02963.x

Human colostrum contains an activity that inhibits the production of IL-2.

J W Hooton 1, H F Pabst 1, D W Spady 1, V Paetkau 1
PMCID: PMC1554205  PMID: 1836162

Abstract

The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor beta.

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Selected References

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