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. 1992 May;88(2):350–355. doi: 10.1111/j.1365-2249.1992.tb03086.x

Effect of interferon-gamma priming on the activation of murine peritoneal macrophages to tumouricidal state by cisplatin, IL-1, and tumour necrosis factor (TNF): production of IL-1 and TNF.

A Sodhi 1, R K Singh 1, S M Singh 1
PMCID: PMC1554310  PMID: 1572101

Abstract

The effect of interferon-gamma (IFN-gamma) priming of murine peritoneal macrophages on the activation to tumouricidal state by cisplatin, lipopolysaccharide (LPS)-IL-1 and TNF was investigated. Cisplatin-, LPS-, IL-1- or TNF-treated IFN-gamma-primed macrophages showed significantly enhanced tumouricidal activity and binding to tumour cells, compared with unprimed treated or untreated macrophages. Macrophages treated with cisplatin, LPS, IL-1 and TNF produced released and membrane-associated IL-1 and TNF activity which was significantly enhanced after priming with IFN-gamma. These observations suggest the use of IFN-gamma along with these biological response modifiers in designing immunotherapeutic protocols for treatment of malignancy.

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Selected References

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  1. Adams D. O., Hamilton T. A. The cell biology of macrophage activation. Annu Rev Immunol. 1984;2:283–318. doi: 10.1146/annurev.iy.02.040184.001435. [DOI] [PubMed] [Google Scholar]
  2. Arend W. P., Gordon D. F., Wood W. M., Janson R. W., Joslin F. G., Jameel S. IL-1 beta production in cultured human monocytes is regulated at multiple levels. J Immunol. 1989 Jul 1;143(1):118–126. [PubMed] [Google Scholar]
  3. Arenzana-Seisdedos F., Virelizier J. L., Fiers W. Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes. J Immunol. 1985 Apr;134(4):2444–2448. [PubMed] [Google Scholar]
  4. Basu S., Sodhi A., Singh S. M., Suresh A. Up-regulation of induction of lymphokine (IL-2)-activated killer (LAK) cell activity by FK-565 and cisplatin. Immunol Lett. 1991 Mar;27(3):199–204. doi: 10.1016/0165-2478(91)90151-y. [DOI] [PubMed] [Google Scholar]
  5. Boraschi D., Censini S., Tagliabue A. Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production. J Immunol. 1984 Aug;133(2):764–768. [PubMed] [Google Scholar]
  6. Burchett S. K., Weaver W. M., Westall J. A., Larsen A., Kronheim S., Wilson C. B. Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes. J Immunol. 1988 May 15;140(10):3473–3481. [PubMed] [Google Scholar]
  7. Collart M. A., Belin D., Vassalli J. D., de Kossodo S., Vassalli P. Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J Exp Med. 1986 Dec 1;164(6):2113–2118. doi: 10.1084/jem.164.6.2113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Crawford R. M., Finbloom D. S., Ohara J., Paul W. E., Meltzer M. S. B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol. 1987 Jul 1;139(1):135–141. [PubMed] [Google Scholar]
  9. Esparza I., Männel D., Ruppel A., Falk W., Krammer P. H. Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. J Exp Med. 1987 Aug 1;166(2):589–594. doi: 10.1084/jem.166.2.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fidler I. J., Schroit A. J. Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self. Biochim Biophys Acta. 1988 Nov 15;948(2):151–173. doi: 10.1016/0304-419x(88)90009-1. [DOI] [PubMed] [Google Scholar]
  11. Flesch I., Kaufmann S. H. Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J Immunol. 1987 Jun 15;138(12):4408–4413. [PubMed] [Google Scholar]
  12. Flick D. A., Gifford G. E. Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J Immunol Methods. 1984 Mar 30;68(1-2):167–175. doi: 10.1016/0022-1759(84)90147-9. [DOI] [PubMed] [Google Scholar]
  13. Geetha B., Sodhi A. Effect of cisplatin, lipopolysaccharide, muramyl dipeptide and recombinant interferon-gamma on murine macrophages in vitro. I. Macrophage-mediated tumor cell lysis. Nat Immun Cell Growth Regul. 1989;8(2):100–107. [PubMed] [Google Scholar]
  14. Grabstein K. H., Urdal D. L., Tushinski R. J., Mochizuki D. Y., Price V. L., Cantrell M. A., Gillis S., Conlon P. J. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science. 1986 Apr 25;232(4749):506–508. doi: 10.1126/science.3083507. [DOI] [PubMed] [Google Scholar]
  15. Gupta P., Sodhi A. Effect of cisplatin on release of lysozyme, plasminogen activator, leucine aminopeptidase and beta-hexosaminidase by murine peritoneal macrophages in vitro. Indian J Exp Biol. 1988 Sep;26(9):679–684. [PubMed] [Google Scholar]
  16. Hart P. H., Whitty G. A., Piccoli D. S., Hamilton J. A. Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity. J Immunol. 1988 Sep 1;141(5):1516–1521. [PubMed] [Google Scholar]
  17. Kagaya K., Fukazawa Y. Murine defense mechanism against Candida albicans infection. II. Opsonization, phagocytosis, and intracellular killing of C. albicans. Microbiol Immunol. 1981;25(8):807–818. doi: 10.1111/j.1348-0421.1981.tb00084.x. [DOI] [PubMed] [Google Scholar]
  18. Kildahl-Andersen O., Espevik T., Nissen-Meyer J. IFN-gamma-induced production of monocyte cytotoxic factor. Cell Immunol. 1985 Oct 15;95(2):392–406. doi: 10.1016/0008-8749(85)90326-0. [DOI] [PubMed] [Google Scholar]
  19. Kleinerman E. S., Zwelling L. A., Muchmore A. V. Enhancement of naturally occurring human spontaneous monocyte-mediated cytotoxicity by cis-diamminedichloroplatinum(II). Cancer Res. 1980 Sep;40(9):3099–3102. [PubMed] [Google Scholar]
  20. Koestler T. P., Johnson W. J., Rieman D., Dalton B. J., Greig R. G., Poste G. Differential expression of murine macrophage-mediated tumor cytotoxicity induced by interferons. Cancer Res. 1987 Jun 1;47(11):2804–2808. [PubMed] [Google Scholar]
  21. Krammer P. H., Kubelka C. F., Falk W., Ruppel A. Priming and triggering of tumoricidal and schistosomulicidal macrophages by two sequential lymphokine signals: interferon-gamma and macrophage cytotoxicity inducing factor 2. J Immunol. 1985 Nov;135(5):3258–3263. [PubMed] [Google Scholar]
  22. Meltzer M. S. Macrophage activation for tumor cytotoxicity: characterization of priming and trigger signals during lymphokine activation. J Immunol. 1981 Jul;127(1):179–183. [PubMed] [Google Scholar]
  23. Mizel S. B. Interleukin 1 and T cell activation. Immunol Rev. 1982;63:51–72. doi: 10.1111/j.1600-065x.1982.tb00411.x. [DOI] [PubMed] [Google Scholar]
  24. Murray H. W., Spitalny G. L., Nathan C. F. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. J Immunol. 1985 Mar;134(3):1619–1622. [PubMed] [Google Scholar]
  25. Newton R. C. Effect of interferon on the induction of human monocyte secretion of interleukin-1 activity. Immunology. 1985 Nov;56(3):441–449. [PMC free article] [PubMed] [Google Scholar]
  26. Okutomi T., Yamazaki M. Augmentation of release of cytotoxin from murine bone marrow macrophages by gamma-interferon. Cancer Res. 1988 Apr 1;48(7):1808–1811. [PubMed] [Google Scholar]
  27. Pace J. L., Russell S. W. Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide. J Immunol. 1981 May;126(5):1863–1867. [PubMed] [Google Scholar]
  28. Pace J. L., Russell S. W., LeBlanc P. A., Murasko D. M. Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing. J Immunol. 1985 Feb;134(2):977–981. [PubMed] [Google Scholar]
  29. Pace J. L., Russell S. W., Torres B. A., Johnson H. M., Gray P. W. Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing. J Immunol. 1983 May;130(5):2011–2013. [PubMed] [Google Scholar]
  30. Paulnock D. M., Lambert L. E. Identification and characterization of monoclonal antibodies specific for macrophages at intermediate stages in the tumoricidal activation pathway. J Immunol. 1990 Jan 15;144(2):765–773. [PubMed] [Google Scholar]
  31. Philip R., Epstein L. B. Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature. 1986 Sep 4;323(6083):86–89. doi: 10.1038/323086a0. [DOI] [PubMed] [Google Scholar]
  32. Rosenberg B. Fundamental studies with cisplatin. Cancer. 1985 May 15;55(10):2303–23l6. doi: 10.1002/1097-0142(19850515)55:10<2303::aid-cncr2820551002>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  33. Schreiber R. D., Hicks L. J., Celada A., Buchmeier N. A., Gray P. W. Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol. 1985 Mar;134(3):1609–1618. [PubMed] [Google Scholar]
  34. Schultz R. M., Kleinschmidt W. J. Functional identity between murine gamma interferon and macrophage activating factor. Nature. 1983 Sep 15;305(5931):239–240. doi: 10.1038/305239a0. [DOI] [PubMed] [Google Scholar]
  35. Singh R. K., Sodhi A., Singh S. M. Production of interleukin-1 and tumor necrosis factor by cisplatin-treated murine peritoneal macrophages. Nat Immun Cell Growth Regul. 1991;10(2):105–116. [PubMed] [Google Scholar]
  36. Singh S. M., Sodhi A. Interaction between cisplatin-treated macrophages and Dalton's lymphoma cells in vitro. Exp Cell Biol. 1988;56(1-2):1–11. doi: 10.1159/000163457. [DOI] [PubMed] [Google Scholar]
  37. Sodhi A., Pai K., Singh R. K., Singh S. M. Activation of human NK cells and monocytes with cisplatin in vitro. Int J Immunopharmacol. 1990;12(8):893–898. doi: 10.1016/0192-0561(90)90008-b. [DOI] [PubMed] [Google Scholar]
  38. Sodhi A., Singh S. M. Release of cytolytic factor(s) by murine macrophages in vitro on treatment with cis-platin. Int J Immunopharmacol. 1986;8(7):701–707. doi: 10.1016/0192-0561(86)90005-6. [DOI] [PubMed] [Google Scholar]

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