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. 1992 Sep;89(3):509–512. doi: 10.1111/j.1365-2249.1992.tb06990.x

Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.

H S Anttila 1, S Reitamo 1, M Ceska 1, M Hurme 1
PMCID: PMC1554478  PMID: 1325308

Abstract

Previous studies have shown that IL-8 gene expression is enhanced by various stimuli, which induce different signal transduction pathways. A lipopolysaccharide (LPS)-induced pathway has been reported to be inhibited by glucocorticoids in monocytes. We have now examined the effect of dexamethasone on the LPS-induced and other signal transduction pathways leading to the production of IL-8 by human monocytes. Dexamethasone inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS. In contrast, dexamethasone had no significant effect on a phorbol ester (PMA)-stimulated IL-8 production. These results suggest that the signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.

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Selected References

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