Abstract
DBA/1 male mice develop arthritis spontaneously at the age of 4 months. The affected joints show cell-rich pannus formation without T cell infiltration and only limited MHC class II expression. Specific pathogen-free DBA/1 mice from different sources developed the same disease. Analyses of inbred mouse strains with various genetic backgrounds and F1 hybrids revealed that the disease is genetically dependent of DBA/1 recessive genes. However, F1 hybrids between DBA/1 and BXSB spontaneously developed arthritis with earlier onset than DBA/1 mice, suggesting that the BXSB autoimmune gene background had both permissive and contributing effects on the development of arthritis. The complete male preponderance for disease susceptibility was investigated by castration and testosterone treatment of DBA/1 males. No arthritis developed after castration and disease susceptibility was restored by testosterone treatment. Arthritis developed only where more than two males were kept in cages, suggesting an influence by aggressive behaviour. Thus, the spontaneous development of arthritis is dependent on hormonal and behavioural mediated effects and differs from experimental models for rheumatoid arthritis such as type II collagen-induced arthritis and pristane-induced arthritis. We conclude that the spontaneously developing arthritis in the normal DBA/1 strain may be more useful as a disease model for osteoarthritis than for rheumatoid arthritis.
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Selected References
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- Bouvet J. P., Couderc J., Bouthillier Y., Franc B., Ducailar A., Mouton D. Spontaneous rheumatoid-like arthritis in a line of mice sensitive to collagen-induced arthritis. Arthritis Rheum. 1990 Nov;33(11):1716–1722. doi: 10.1002/art.1780331116. [DOI] [PubMed] [Google Scholar]
- Bremell T., Lange S., Svensson L., Jennische E., Gröndahl K., Carlsten H., Tarkowski A. Outbreak of spontaneous staphylococcal arthritis and osteitis in mice. Arthritis Rheum. 1990 Nov;33(11):1739–1744. doi: 10.1002/art.1780331120. [DOI] [PubMed] [Google Scholar]
- Chang Y. H., Pearson C. M., Abe C. Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: immunologic, histopathologic, and other studies. Arthritis Rheum. 1980 Jan;23(1):62–71. doi: 10.1002/art.1780230111. [DOI] [PubMed] [Google Scholar]
- Hang L., Theofilopoulos A. N., Dixon F. J. A spontaneous rheumatoid arthritis-like disease in MRL/l mice. J Exp Med. 1982 Jun 1;155(6):1690–1701. doi: 10.1084/jem.155.6.1690. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmdahl R., Andersson M., Goldschmidt T. J., Gustafsson K., Jansson L., Mo J. A. Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990 Dec;118:193–232. doi: 10.1111/j.1600-065x.1990.tb00817.x. [DOI] [PubMed] [Google Scholar]
- Holmdahl R., Jansson L., Andersson M., Larsson E. Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis. Immunology. 1988 Oct;65(2):305–310. [PMC free article] [PubMed] [Google Scholar]
- Holmdahl R., Jansson L., Gullberg D., Rubin K., Forsberg P. O., Klareskog L. Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin Exp Immunol. 1985 Dec;62(3):639–646. [PMC free article] [PubMed] [Google Scholar]
- Holmdahl R., Jonsson R., Larsson P., Klareskog L. Early appearance of activated CD4+ T lymphocytes and class II antigen-expressing cells in joints of DBA/1 mice immunized with type II collagen. Lab Invest. 1988 Jan;58(1):53–60. [PubMed] [Google Scholar]
- Holmdahl R., Klareskog L., Andersson M., Hansen C. High antibody response to autologous type II collagen is restricted to H-2q. Immunogenetics. 1986;24(2):84–89. doi: 10.1007/BF00373114. [DOI] [PubMed] [Google Scholar]
- Iwakura Y., Tosu M., Yoshida E., Takiguchi M., Sato K., Kitajima I., Nishioka K., Yamamoto K., Takeda T., Hatanaka M. Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science. 1991 Aug 30;253(5023):1026–1028. doi: 10.1126/science.1887217. [DOI] [PubMed] [Google Scholar]
- Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
- Londei M., Savill C. M., Verhoef A., Brennan F., Leech Z. A., Duance V., Maini R. N., Feldmann M. Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci U S A. 1989 Jan;86(2):636–640. doi: 10.1073/pnas.86.2.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakamura K., Kashiwazaki S., Takagishi K., Tsukamoto Y., Morohoshi Y., Nakano T., Kimura M. Spontaneous degenerative polyarthritis in male New Zealand black/KN mice. Arthritis Rheum. 1991 Feb;34(2):171–179. doi: 10.1002/art.1780340207. [DOI] [PubMed] [Google Scholar]
- Nepom G. T., Byers P., Seyfried C., Healey L. A., Wilske K. R., Stage D., Nepom B. S. HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum. 1989 Jan;32(1):15–21. doi: 10.1002/anr.1780320104. [DOI] [PubMed] [Google Scholar]
- PEARSON C. M. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. doi: 10.3181/00379727-91-22179. [DOI] [PubMed] [Google Scholar]
- Potter M., Wax J. S. Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis. J Immunol. 1981 Oct;127(4):1591–1595. [PubMed] [Google Scholar]
- Rogers M. P., Trentham D. E., Dynesius-Trentham R., Daffner K., Reich P. Exacerbation of collagen arthritis by noise stress. J Rheumatol. 1983 Aug;10(4):651–654. [PubMed] [Google Scholar]
- Rogers M. P., Trentham D. E., McCune W. J., Ginsberg B. I., Rennke H. G., Reich P., David J. R. Effect of psychological stress on the induction of arthritis in rats. Arthritis Rheum. 1980 Dec;23(12):1337–1342. doi: 10.1002/art.1780231202. [DOI] [PubMed] [Google Scholar]
- Tarkowski A., Holmdahl R., Rubin K., Klareskog L., Nilsson L. A., Gunnarsson K. Patterns of autoreactivity to collagen type II in autoimmune MRL/l mice. Clin Exp Immunol. 1986 Feb;63(2):441–449. [PMC free article] [PubMed] [Google Scholar]
- Tarkowski A., Jonsson R., Holmdahl R., Klareskog L. Immunohistochemical characterization of synovial cells in arthritic MRL-lpr/lpr mice. Arthritis Rheum. 1987 Jan;30(1):75–82. doi: 10.1002/art.1780300110. [DOI] [PubMed] [Google Scholar]
- Theofilopoulos A. N., Dixon F. J. Murine models of systemic lupus erythematosus. Adv Immunol. 1985;37:269–390. doi: 10.1016/s0065-2776(08)60342-9. [DOI] [PubMed] [Google Scholar]
- Wooley P. H., Seibold J. R., Whalen J. D., Chapdelaine J. M. Pristane-induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease. Arthritis Rheum. 1989 Aug;32(8):1022–1030. doi: 10.1002/anr.1780320812. [DOI] [PubMed] [Google Scholar]