Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1992 Oct;90(1):68–71. doi: 10.1111/j.1365-2249.1992.tb05833.x

Tumour necrosis factor enhances the asbestos-induced production of reactive oxygen metabolites by human polymorphonuclear leucocytes (PMN).

M Klockars 1, H Savolainen 1
PMCID: PMC1554544  PMID: 1395103

Abstract

We studied the effect of recombinant tumour necrosis factor-alpha (TNF-alpha) on the production of reactive oxygen metabolites (ROM) by human PMN exposed in vitro to chrysotile and crocidolite asbestos fibres, quartz dusts and opsonized zymosan. TNF caused a significant increase in ROM release by PMN, and significantly and dose-dependently amplified the ROM production induced by asbestos fibres. The amplification of ROM production by TNF can be of crucial importance in the process of lung inflammation and fibrogenesis in pneumoconioses.

Full text

PDF
68

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becklake M. R. Exposure to asbestos and human disease. N Engl J Med. 1982 Jun 17;306(24):1480–1482. doi: 10.1056/NEJM198206173062409. [DOI] [PubMed] [Google Scholar]
  2. Berkow R. L., Wang D., Larrick J. W., Dodson R. W., Howard T. H. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor. J Immunol. 1987 Dec 1;139(11):3783–3791. [PubMed] [Google Scholar]
  3. Beutler B., Cerami A. Cachectin: more than a tumor necrosis factor. N Engl J Med. 1987 Feb 12;316(7):379–385. doi: 10.1056/NEJM198702123160705. [DOI] [PubMed] [Google Scholar]
  4. Birnboim H. C. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can J Physiol Pharmacol. 1982 Nov;60(11):1359–1366. doi: 10.1139/y82-203. [DOI] [PubMed] [Google Scholar]
  5. Bégin R. O., Cantin A. M., Boileau R. D., Bisson G. Y. Spectrum of alveolitis in quartz-exposed human subjects. Chest. 1987 Dec;92(6):1061–1067. doi: 10.1378/chest.92.6.1061. [DOI] [PubMed] [Google Scholar]
  6. Bégin R., Cantin A., Berthiaume Y., Boileau R., Bisson G., Lamoureux G., Rola-Pleszczynski M., Drapeau G., Massé S., Boctor M. Clinical features to stage alveolitis in asbestos workers. Am J Ind Med. 1985;8(6):521–536. doi: 10.1002/ajim.4700080604. [DOI] [PubMed] [Google Scholar]
  7. Cerami A. Inflammatory cytokines. Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S3–10. doi: 10.1016/0090-1229(92)90035-m. [DOI] [PubMed] [Google Scholar]
  8. Djeu J. Y., Blanchard D. K., Halkias D., Friedman H. Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol. 1986 Nov 1;137(9):2980–2984. [PubMed] [Google Scholar]
  9. Dubois C. M., Bissonnette E., Rola-Pleszczynski M. Asbestos fibers and silica particles stimulate rat alveolar macrophages to release tumor necrosis factor. Autoregulatory role of leukotriene B4. Am Rev Respir Dis. 1989 May;139(5):1257–1264. doi: 10.1164/ajrccm/139.5.1257. [DOI] [PubMed] [Google Scholar]
  10. Gamble J. R., Harlan J. M., Klebanoff S. J., Vadas M. A. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8667–8671. doi: 10.1073/pnas.82.24.8667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Halliwell B., Gutteridge J. M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J. 1984 Apr 1;219(1):1–14. doi: 10.1042/bj2190001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hedenborg M., Klockars M. Production of reactive oxygen metabolites induced by asbestos fibres in human polymorphonuclear leucocytes. J Clin Pathol. 1987 Oct;40(10):1189–1193. doi: 10.1136/jcp.40.10.1189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hedenborg M., Klockars M. Quartz-dust-induced production of reactive oxygen metabolites by human granulocytes. Lung. 1989;167(1):23–32. doi: 10.1007/BF02714927. [DOI] [PubMed] [Google Scholar]
  14. Johnson K. J., Fantone J. C., 3rd, Kaplan J., Ward P. A. In vivo damage of rat lungs by oxygen metabolites. J Clin Invest. 1981 Apr;67(4):983–993. doi: 10.1172/JCI110149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Jones G. R. Free radicals in immunological killing: the case of tumor necrotising factor (TNF). Med Hypotheses. 1986 Nov;21(3):267–271. doi: 10.1016/0306-9877(86)90019-8. [DOI] [PubMed] [Google Scholar]
  16. Jättelä M. Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. Lab Invest. 1991 Jun;64(6):724–742. [PubMed] [Google Scholar]
  17. Klebanoff S. J., Vadas M. A., Harlan J. M., Sparks L. H., Gamble J. R., Agosti J. M., Waltersdorph A. M. Stimulation of neutrophils by tumor necrosis factor. J Immunol. 1986 Jun 1;136(11):4220–4225. [PubMed] [Google Scholar]
  18. Klockars M., Hedenborg M., Koistinen J., Isobe T. IgG and IgA enhance the chrysotile-induced production of reactive oxygen metabolites by human polymorphonuclear leucocytes. Clin Exp Immunol. 1989 Dec;78(3):372–377. [PMC free article] [PubMed] [Google Scholar]
  19. Matthews N., Neale M. L., Jackson S. K., Stark J. M. Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism. Immunology. 1987 Sep;62(1):153–155. [PMC free article] [PubMed] [Google Scholar]
  20. Movat H. Z., Burrowes C. E., Cybulsky M. I., Dinarello C. A. Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am J Pathol. 1987 Dec;129(3):463–476. [PMC free article] [PubMed] [Google Scholar]
  21. Nyberg P., Klockars M. Effect of immunoglobulins on mineral dust-induced production of reactive oxygen metabolites by human macrophages. Inflammation. 1990 Dec;14(6):621–629. doi: 10.1007/BF00916366. [DOI] [PubMed] [Google Scholar]
  22. Nyberg P., Klockars M. Measurement of reactive oxygen metabolites produced by human monocyte-derived macrophages exposed to mineral dusts. Int J Exp Pathol. 1990 Aug;71(4):537–544. [PMC free article] [PubMed] [Google Scholar]
  23. Piguet P. F., Collart M. A., Grau G. E., Sappino A. P., Vassalli P. Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature. 1990 Mar 15;344(6263):245–247. doi: 10.1038/344245a0. [DOI] [PubMed] [Google Scholar]
  24. Piguet P. F., Grau G. E., Vassalli P. Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis. Am J Pathol. 1990 Jan;136(1):103–110. [PMC free article] [PubMed] [Google Scholar]
  25. Rola-Pleszczynski M., Rivest D., Bérardi M. Asbestos-induced chemiluminescence response of human polymorphonuclear leukocytes. Environ Res. 1984 Feb;33(1):1–6. doi: 10.1016/0013-9351(84)90002-1. [DOI] [PubMed] [Google Scholar]
  26. Sacks T., Moldow C. F., Craddock P. R., Bowers T. K., Jacob H. S. Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage. J Clin Invest. 1978 May;61(5):1161–1167. doi: 10.1172/JCI109031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shalaby M. R., Aggarwal B. B., Rinderknecht E., Svedersky L. P., Finkle B. S., Palladino M. A., Jr Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985 Sep;135(3):2069–2073. [PubMed] [Google Scholar]
  28. She Z. W., Wewers M. D., Herzyk D. J., Sagone A. L., Davis W. B. Tumor necrosis factor primes neutrophils for hypochlorous acid production. Am J Physiol. 1989 Dec;257(6 Pt 1):L338–L345. doi: 10.1152/ajplung.1989.257.6.L338. [DOI] [PubMed] [Google Scholar]
  29. Silberstein D. S., David J. R. Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae. Proc Natl Acad Sci U S A. 1986 Feb;83(4):1055–1059. doi: 10.1073/pnas.83.4.1055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Tossavainen A. Determination of quartz on membrane filters by X-ray diffraction. Scand J Work Environ Health. 1979 Dec;5(4):379–385. doi: 10.5271/sjweh.2652. [DOI] [PubMed] [Google Scholar]
  31. Tracey K. J., Wei H., Manogue K. R., Fong Y., Hesse D. G., Nguyen H. T., Kuo G. C., Beutler B., Cotran R. S., Cerami A. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 1988 Mar 1;167(3):1211–1227. doi: 10.1084/jem.167.3.1211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Vilcek J., Palombella V. J., Henriksen-DeStefano D., Swenson C., Feinman R., Hirai M., Tsujimoto M. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J Exp Med. 1986 Mar 1;163(3):632–643. doi: 10.1084/jem.163.3.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Weitberg A. B., Weitzman S. A., Destrempes M., Latt S. A., Stossel T. P. Stimulated human phagocytes produce cytogenetic changes in cultured mammalian cells. N Engl J Med. 1983 Jan 6;308(1):26–30. doi: 10.1056/NEJM198301063080107. [DOI] [PubMed] [Google Scholar]
  34. Wewers M. D., Rinehart J. J., She Z. W., Herzyk D. J., Hummel M. M., Kinney P. A., Davis W. B. Tumor necrosis factor infusions in humans prime neutrophils for hypochlorous acid production. Am J Physiol. 1990 Oct;259(4 Pt 1):L276–L282. doi: 10.1152/ajplung.1990.259.4.L276. [DOI] [PubMed] [Google Scholar]
  35. Wong G. H., Goeddel D. V. Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science. 1988 Nov 11;242(4880):941–944. doi: 10.1126/science.3263703. [DOI] [PubMed] [Google Scholar]
  36. Yamauchi N., Kuriyama H., Watanabe N., Neda H., Maeda M., Niitsu Y. Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro. Cancer Res. 1989 Apr 1;49(7):1671–1675. [PubMed] [Google Scholar]
  37. Zimmerman R. J., Chan A., Leadon S. A. Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor. Cancer Res. 1989 Apr 1;49(7):1644–1648. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES