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. 1992 Dec;90(3):422–427. doi: 10.1111/j.1365-2249.1992.tb05862.x

Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease.

A Kratz 1, M W Harding 1, J Craft 1, C G Mackworth-Young 1, R E Handschumacher 1
PMCID: PMC1554566  PMID: 1458678

Abstract

Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients. The antibodies are directed against the denatured form of both the major and minor isoform of cyclophilin and can be demonstrated in Western blots. Some first-degree relatives of lupus patients also express these antibodies. They are specific for cyclophilin and are not the consequence of hypergammaglobulinaemia. Four monoclonal IgM antibodies from a patient with lepromatous leprosy also bound to cyclophilin. The generation of these antibodies may be of special interest because they are against a protein involved in the control of the immune system not known to be directly associated with DNA or RNA.

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Selected References

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