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. 1992 Nov;90(2):260–265. doi: 10.1111/j.1365-2249.1992.tb07939.x

Suppression of spontaneous murine lupus by inducing graft-versus-host reaction with CD8+ cells.

S Ito 1, M Ueno 1, S Nishi 1, M Arakawa 1, M Fujiwara 1
PMCID: PMC1554597  PMID: 1424284

Abstract

Splenic CD8+ (Lyt-2+) cells of C57BL/6 mice were injected into semiallogeneic (NZB x BXSB)F1 mice, which spontaneously develop lupus nephritis, in order to examine whether the disease was somehow modified by the occurrence of graft-versus-host reaction. The development of lupus nephritis in the F1 recipients was strongly inhibited and immunopathological parameters such as anti-DNA antibodies, circulating immune complexes (CIC) and splenic immunoglobulin-producing cells (IgPC) were markedly reduced. The injection of CD4+ (L3T4+) T cells into F1 recipients did not result in similar effects. These findings suggest that the development of autoimmune disease could be ameliorated by CD8+ cells responding to MHC class I antigens. The significance of the data is discussed in terms of the treatment of autoimmune diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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