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. 1993 Jan;91(1):103–109. doi: 10.1111/j.1365-2249.1993.tb03362.x

Ro/SSA inhibits the autologous mixed lymphocyte reaction.

J Karsh 1, J B Harley 1, R Goldstein 1, A I Lazarovits 1
PMCID: PMC1554653  PMID: 7678209

Abstract

To test the hypothesis that the Ro/SSA autoantigen can be recognized as antigenic by the human immune system, lymphocytes obtained from normal volunteers were used in in vitro assays evaluating the ability of Ro/SSA (mol. wt 60 kD) to induce B and/or T cell responses. Bovine Ro/SSA strongly inhibited the autologous mixed lymphocyte reaction in a dose-dependent manner without similar effects on concurrently performed allogeneic mixed lymphocyte reactions or T cell proliferation induced by phytohaemagglutinin. Using three colour FACS analysis, Ro/SSA was found to decrease the percentage of CD4+CD45+RA+ T cells in the proliferative, S+(G2+M), phase of the cell cycle. Associated with the decrease in the percentage of suppressor-inducer cells, was the finding that Ro/SSA was able to augment RF production in pokeweed mitogen stimulated cultures of peripheral blood lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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