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. 1993 Feb;91(2):287–294. doi: 10.1111/j.1365-2249.1993.tb05897.x

Cytokine-induced inhibition of Plasmodium falciparum erythrocytic growth in vitro.

A S Orago 1, C A Facer 1
PMCID: PMC1554667  PMID: 8428394

Abstract

The addition of recombinant cytokines to Plasmodium falciparum in vitro cultures retarded the growth of the parasite with the effect of recombinant IL-2 (rIL-2) > interferon-gamma (IFN-gamma) > tumour necrosis factor-beta (TNF-beta). The process was concentration dependent, being greatest at 30,000 U/ml and required a 72-h period of continuous exposure for maximum effect. Growth inhibition, as determined morphologically and radiometrically, was a consequence of defective schizont maturation rather than inhibition of merozoite invasion. It was cumulative and detectable within one erythrocytic (48 h) growth cycle.

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Selected References

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