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. 1993 Feb;91(2):196–201. doi: 10.1111/j.1365-2249.1993.tb05882.x

Common idiotypes expressed on human, monoclonal, abnormal immunoglobulins and cryoglobulins with polyreactive autoantibody activities.

M R Barbouche 1, B Guilbert 1, S Makni 1, Y Gorgi 1, K Ayed 1, S Avrameas 1
PMCID: PMC1554692  PMID: 8428386

Abstract

Several human monoclonal immunoglobulins with the same autoantibody activity have been shown to have cross-reactive idiotypes (CRI). In this study, using polyclonal anti-idiotypic antibodies, we found that 28% of human monoclonal immunoglobulins with polyreactive autoantibody activity from myeloma, Waldenström's macroglobulinaemia and cryoglobulinaemia patients shared common idiotype(s). Furthermore, the latter were expressed on human and murine natural MoAbs (respectively in 12% and 22% of the clones tested) and on human IgG preparations used for therapeutic intravenous injections (IVIg) and which contain natural antibodies. These findings suggest that monoclonal immunoglobulins could arise from the proliferation of a clone that normally produces a natural antibody. The existence of common idiotype(s) between monoclonal immunoglobulins and IVIg could be relevant to the improvement noted after treatment with IVIg in patients suffering from peripheral neuropathies associated with monoclonal gammopathy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Araujo P. M., Holmberg D., Martinez-A C., Coutinho A. Idiotypic multireactivity of 'natural' antibodies. 'Natural' anti-idiotypes also inhibit helper cells with cross-reactive clonotypes. Scand J Immunol. 1987 May;25(5):497–505. doi: 10.1111/j.1365-3083.1987.tb02221.x. [DOI] [PubMed] [Google Scholar]
  2. Avrameas S. Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'. Immunol Today. 1991 May;12(5):154–159. doi: 10.1016/S0167-5699(05)80045-3. [DOI] [PubMed] [Google Scholar]
  3. Barbouche R., Forveille M., Fischer A., Avrameas S., Durandy A. Spontaneous IgM autoantibody production in vitro by B lymphocytes of normal human neonates. Scand J Immunol. 1992 Jun;35(6):659–667. doi: 10.1111/j.1365-3083.1992.tb02972.x. [DOI] [PubMed] [Google Scholar]
  4. Borche L., Lim A., Binet J. L., Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood. 1990 Aug 1;76(3):562–569. [PubMed] [Google Scholar]
  5. Bouvet J. P., Pires R., Pillot J. A modified gel filtration technique producing an unusual exclusion volume of IgM: a simple way of preparing monoclonal IgM. J Immunol Methods. 1984 Feb 10;66(2):299–305. doi: 10.1016/0022-1759(84)90341-7. [DOI] [PubMed] [Google Scholar]
  6. Bröker B. M., Klajman A., Youinou P., Jouquan J., Worman C. P., Murphy J., Mackenzie L., Quartey-Papafio R., Blaschek M., Collins P. Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies. J Autoimmun. 1988 Oct;1(5):469–481. doi: 10.1016/0896-8411(88)90068-6. [DOI] [PubMed] [Google Scholar]
  7. Casali P., Notkins A. L. Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu Rev Immunol. 1989;7:513–535. doi: 10.1146/annurev.iy.07.040189.002501. [DOI] [PubMed] [Google Scholar]
  8. Chen P. P., Goñi F., Fong S., Jirik F., Vaughan J. H., Frangione B., Carson D. A. The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. J Immunol. 1985 May;134(5):3281–3285. [PubMed] [Google Scholar]
  9. Clezardin P., McGregor J. L., Manach M., Boukerche H., Dechavanne M. One-step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by fast protein liquid chromatography on a mono Q anion-exchange column. J Chromatogr. 1985 Jan 25;319(1):67–77. doi: 10.1016/s0021-9673(01)90540-0. [DOI] [PubMed] [Google Scholar]
  10. Cook D., Dalakas M., Galdi A., Biondi D., Porter H. High-dose intravenous immunoglobulin in the treatment of demyelinating neuropathy associated with monoclonal gammopathy. Neurology. 1990 Feb;40(2):212–214. doi: 10.1212/wnl.40.2.212. [DOI] [PubMed] [Google Scholar]
  11. Dellagi K., Brouet J. C., Perreau J., Paulin D. Human monoclonal IgM with autoantibody activity against intermediate filaments. Proc Natl Acad Sci U S A. 1982 Jan;79(2):446–450. doi: 10.1073/pnas.79.2.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Dighiero G., Guilbert B., Avrameas S. Naturally occurring antibodies against nine common antigens in humans sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies. J Immunol. 1982 Jun;128(6):2788–2792. [PubMed] [Google Scholar]
  13. Dighiero G., Guilbert B., Fermand J. P., Lymberi P., Danon F., Avrameas S. Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations. Blood. 1983 Aug;62(2):264–270. [PubMed] [Google Scholar]
  14. Dighiero G., Lymberi P., Mazié J. C., Rouyre S., Butler-Browne G. S., Whalen R. G., Avrameas S. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J Immunol. 1983 Nov;131(5):2267–2272. [PubMed] [Google Scholar]
  15. Geltner D., Franklin E. C., Frangione B. Antiidiotypic activity in the IgM fractions of mixed cryoglobulins. J Immunol. 1980 Oct;125(4):1530–1535. [PubMed] [Google Scholar]
  16. Gorevic P. D., Frangione B. Mixed cryoglobulinemia cross-reactive idiotypes: implications for the relationship of MC to rheumatic and lymphoproliferative diseases. Semin Hematol. 1991 Apr;28(2):79–94. [PubMed] [Google Scholar]
  17. Guigou V., Guilbert B., Moinier D., Tonnelle C., Boubli L., Avrameas S., Fougereau M., Fumoux F. Ig repertoire of human polyspecific antibodies and B cell ontogeny. J Immunol. 1991 Feb 15;146(4):1368–1374. [PubMed] [Google Scholar]
  18. KRITZMAN J., KUNKEL H. G., MCCARTHY J., MELLORS R. C. Studies of a Waldenstrom-type macroglobulin with rheumatoid factor properties. J Lab Clin Med. 1961 Jun;57:905–917. [PubMed] [Google Scholar]
  19. Kaveri S. V., Dietrich G., Hurez V., Kazatchkine M. D. Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases. Clin Exp Immunol. 1991 Nov;86(2):192–198. doi: 10.1111/j.1365-2249.1991.tb05794.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kipps T. J. The CD5 B cell. Adv Immunol. 1989;47:117–185. doi: 10.1016/s0065-2776(08)60663-x. [DOI] [PubMed] [Google Scholar]
  21. Kipps T. J., Tomhave E., Chen P. P., Carson D. A. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. J Exp Med. 1988 Mar 1;167(3):840–852. doi: 10.1084/jem.167.3.840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kunkel H. G., Agnello V., Joslin F. G., Winchester R. J., Capra J. D. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med. 1973 Feb 1;137(2):331–342. doi: 10.1084/jem.137.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Langone J. J. Applications of immobilized protein A in immunochemical techniques. J Immunol Methods. 1982 Dec 30;55(3):277–296. doi: 10.1016/0022-1759(82)90088-6. [DOI] [PubMed] [Google Scholar]
  24. Little J. R., Eisen H. N. Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group. Biochemistry. 1966 Nov;5(11):3385–3395. doi: 10.1021/bi00875a001. [DOI] [PubMed] [Google Scholar]
  25. Lymberi P., Dighiero G., Ternynck T., Avrameas S. A high incidence of cross-reactive idiotypes among murine natural autoantibodies. Eur J Immunol. 1985 Jul;15(7):702–707. doi: 10.1002/eji.1830150712. [DOI] [PubMed] [Google Scholar]
  26. Paavonen T., Quartey-Papafio R., Delves P. J., Mackenzie L., Lund T., Youinou P., Lydyard P. M. CD5 mRNA expression and auto-antibody production in early human B cells immortalized by EBV. Scand J Immunol. 1990 Mar;31(3):269–274. doi: 10.1111/j.1365-3083.1990.tb02768.x. [DOI] [PubMed] [Google Scholar]
  27. Pasquali J. L., Martin T., Knapp A. M., Levallois H., Farradji A. Monoclonal rheumatoid factor-secreting cells in a patient with mixed cryoglobulinemia. Homogeneity and stability of the idiotypic production and in vitro idiotypic suppression. J Immunol. 1989 Sep 15;143(6):1826–1831. [PubMed] [Google Scholar]
  28. Rossi F., Guilbert B., Tonnelle C., Ternynck T., Fumoux F., Avrameas S., Kazatchkine M. D. Idiotypic interactions between normal human polyspecific IgG and natural IgM antibodies. Eur J Immunol. 1990 Sep;20(9):2089–2094. doi: 10.1002/eji.1830200930. [DOI] [PubMed] [Google Scholar]
  29. Schmitt C., Dellagi K., Mihaesco E., Brouet J. C. Detection of cross-reactive determinants shared by human monoclonal IgM reacting with myelin-associated glycoprotein. J Immunol. 1987 Mar 1;138(5):1442–1446. [PubMed] [Google Scholar]
  30. Seigneurin J. M., Guilbert B., Bourgeat M. J., Avrameas S. Polyspecific natural antibodies and autoantibodies secreted by human lymphocytes immortalized with Epstein-Barr virus. Blood. 1988 Mar;71(3):581–585. [PubMed] [Google Scholar]
  31. Seligmann M., Brouet J. C. Antibody activity of human myeloma globulins. Semin Hematol. 1973 Apr;10(2):163–177. [PubMed] [Google Scholar]
  32. Shelanski M. L., Gaskin F., Cantor C. R. Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci U S A. 1973 Mar;70(3):765–768. doi: 10.1073/pnas.70.3.765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Spertini F., Donati Y., Welle I., Izui S., Lambert P. H. Prevention of murine cryoglobulinemia and associated pathology by monoclonal anti-idiotypic antibody. J Immunol. 1989 Oct 15;143(8):2508–2513. [PubMed] [Google Scholar]
  34. Spudich J. A., Watt S. The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J Biol Chem. 1971 Aug 10;246(15):4866–4871. [PubMed] [Google Scholar]
  35. Whalen R. G., Butler-Browne G. S., Gros F. Identification of a novel form of myosin light chain present in embryonic muscle tissue and cultured muscle cells. J Mol Biol. 1978 Dec 15;126(3):415–431. doi: 10.1016/0022-2836(78)90049-9. [DOI] [PubMed] [Google Scholar]
  36. Willims R. C., Jr, Kunkel H. G., Capra J. D. Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science. 1968 Jul 26;161(3839):379–381. doi: 10.1126/science.161.3839.379. [DOI] [PubMed] [Google Scholar]
  37. Zouali M., Fine J. M., Eyquem A. A human monoclonal IgG1 with anti-idiotypic activity against anti-human thyroglobulin autoantibody. J Immunol. 1984 Jul;133(1):190–194. [PubMed] [Google Scholar]
  38. Zouali M., Fine J. M., Eyquem A. Anti-DNA autoantibody activity and idiotypic relationships of human monoclonal proteins. Eur J Immunol. 1984 Dec;14(12):1085–1089. doi: 10.1002/eji.1830141204. [DOI] [PubMed] [Google Scholar]

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