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. 1993 Jul;93(1):103–107. doi: 10.1111/j.1365-2249.1993.tb06504.x

Expression of types I, III and IV collagen genes in fibrotic skin and nerve lesions of toxic oil syndrome patients.

J J Gomez-Reino 1, M Sandberg 1, P E Carreira 1, E Vuorio 1
PMCID: PMC1554755  PMID: 8391940

Abstract

We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cells within the fibrotic process of the nerves. These results suggest that the excessive accumulation of collagen in toxic oil syndrome results from transcriptional activation of collagen genes in a subpopulation of fibroblasts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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