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. 1993 Apr;92(1):169–173. doi: 10.1111/j.1365-2249.1993.tb05965.x

Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans.

E E Arreaza 1, J J Gibbons Jr 1, G W Siskind 1, M E Weksler 1
PMCID: PMC1554869  PMID: 8467560

Abstract

The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody concentration was higher in old compared with young humans before boosting with TT, and (iii) anti-TT antibodies from different humans shared Id cross-reactivity when tested with a rabbit anti-Id antibody. Thus, the serum anti-TT antibody response to boosting was inversely correlated with the serum level of auto-anti-Id. This conclusion is consistent with the view that the higher level of auto-anti-antibody in older subjects contributes to their impaired antibody response to TT.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bona C., Paul W. E. Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med. 1979 Mar 1;149(3):592–600. doi: 10.1084/jem.149.3.592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cosenza H. Detection of anti-idiotype reactive cells in the response to phosphorylcholine. Eur J Immunol. 1976 Feb;6(2):114–116. doi: 10.1002/eji.1830060208. [DOI] [PubMed] [Google Scholar]
  3. Eichmann K., Rajewsky K. Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol. 1975 Oct;5(10):661–666. doi: 10.1002/eji.1830051002. [DOI] [PubMed] [Google Scholar]
  4. Geha R. S. Presence of auto-anti-idiotypic antibody during the normal human immune response to tetanus toxoid antigen. J Immunol. 1982 Jul;129(1):139–144. [PubMed] [Google Scholar]
  5. Goidl E. A., Thorbecke G. J., Weksler M. E., Siskind G. W. Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6788–6792. doi: 10.1073/pnas.77.11.6788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hallgren H. M., Buckley C. E., 3rd, Gilbertsen V. A., Yunis E. J. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol. 1973 Oct;111(4):1101–1107. [PubMed] [Google Scholar]
  7. Hoffman W. L., Strucely P. D., Jump A. A., Smiley J. D. A restricted human antitetanus clonotype shares idiotypic cross-reactivity with tetanus antibodies from most human donors and rabbits: reactivity with antibodies of widely differing electrophoretic mobility. J Immunol. 1985 Dec;135(6):3802–3807. [PubMed] [Google Scholar]
  8. Kishimoto S., Tomino S., Mitsuya H., Nishimura H. Age-related decrease in frequencies of B-cell precursors and specific helper T cells involved in the IgG anti-tetanus toxoid antibody production in humans. Clin Immunol Immunopathol. 1982 Oct;25(1):1–10. doi: 10.1016/0090-1229(82)90159-3. [DOI] [PubMed] [Google Scholar]
  9. Price G. B., Makinodan T. Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies. J Immunol. 1972 Feb;108(2):403–412. [PubMed] [Google Scholar]
  10. Price G. B., Makinodan T. Immunologic deficiencies in senescence. II. Characterization of extrinsic deficiencies. J Immunol. 1972 Feb;108(2):413–417. [PubMed] [Google Scholar]
  11. Rowley M. J., Buchanan H., Mackay I. R. Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet. 1968 Jul 6;2(7558):24–26. doi: 10.1016/s0140-6736(68)92893-6. [DOI] [PubMed] [Google Scholar]
  12. Saxon A., Barnett E. Human auto-antiidiotypes regulating T cell-mediated reactivity to tetanus toxoid. J Clin Invest. 1984 Feb;73(2):342–348. doi: 10.1172/JCI111218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Schrater A. F., Goidl E. A., Thorbecke G. J., Siskind G. W. Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells. J Exp Med. 1979 Jul 1;150(1):138–153. doi: 10.1084/jem.150.1.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wettendorff M., Iliopoulos D., Schmoll E., Koprowski H., Herlyn D. Specific detection of antibodies in cancer patients following immunotherapy with anti-idiotype. J Immunol Methods. 1989 Jan 6;116(1):105–115. doi: 10.1016/0022-1759(89)90318-9. [DOI] [PubMed] [Google Scholar]
  15. Yeni P., Carbon C., Tremolieres F., Gibert C. Serum levels of antibody to toxoid during tetanus and after specific immunization of patients with tetanus. J Infect Dis. 1982 Feb;145(2):278–278. doi: 10.1093/infdis/145.2.278. [DOI] [PubMed] [Google Scholar]

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