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. 1981 Nov;44(3):481–488.

Lymphokine-mediated stimulation of eosinophil migration in the guinea-pig.

W B van den Berg, J van Tuyl, P Sminia, T M Jentjens, R J Scheper
PMCID: PMC1554965  PMID: 7319548

Abstract

Guinea-pig lymphokines were shown to stimulate the migration of eosinophils from capillary tubes. Eosinophil migration stimulatory activity was produced by Freund's complete adjuvant (FCA)-sensitized lymph node or peritoneal exudate lymphocytes in the presence of purified protein derivative (PPD), as well as by Con A-stimulated lymph node lymphocytes. Like murine and human eosinophil-stimulation promoter lymphokine (ESP), the guinea-pig lymphokine activity is T cell-derived, non-dialysable and resistant to heating at 56 degrees. In contrast to the migration inhibition factor (MIF) which could be adsorbed by macrophages, eosinophil migration stimulatory activity could not be removed by pre-adsorption to macrophages or eosinophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anwar A. R., Smithers S. R., Kay A. B. Killing of schistosomula of Schistosoma mansoni coated with antibody and/or complement by human leukocytes in vitro: requirement for complement in preferential killing by eosinophils. J Immunol. 1979 Feb;122(2):628–637. [PubMed] [Google Scholar]
  2. Bloom B. R., Jimenez L. Migration inhibitory factor and the cellular basis of delayed-type hypersensitivity reactions. Am J Pathol. 1970 Sep;60(3):453–468. [PMC free article] [PubMed] [Google Scholar]
  3. Cohen S., Ward P. A. In vitro and in vivo activity of a lymphocyte and immune complex-dependent chemotactic factor for eosinophils. J Exp Med. 1971 Jan 1;133(1):133–146. doi: 10.1084/jem.133.1.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Colley D. G. Eosinophils and immune mechanisms. Eosinophil stimulation promoter (ESP): a lymphokine induced by specific antigen or phytohemagglutinin. J Immunol. 1973 May;110(5):1419–1423. [PubMed] [Google Scholar]
  5. DeFranco M. F., Hanson J. M., Morley J., Wolstencroft R. A., Dumonde D. C. Leucocyte chemotactic activity in the parallel bioassay of guinea--pig lymphokines. Immunology. 1977 Feb;32(2):179–190. [PMC free article] [PubMed] [Google Scholar]
  6. Gleich G. J., Loegering D. Selective stimulation and purification of eosinophils and neutrophils from guinea pig peritoneal fluids. J Lab Clin Med. 1973 Sep;82(3):522–528. [PubMed] [Google Scholar]
  7. Greene B. M., Colley D. G. Eosinophils and immune mechanisms. II. Partial characterization of the lymphokine eosinophil stimulation promoter. J Immunol. 1974 Sep;113(3):910–917. [PubMed] [Google Scholar]
  8. Greene B. M., Colley D. G. Eosinophils and immune mechanisms. III. Production of the lymphokine eosinophil stimulation promoter by mouse T lymphocytes. J Immunol. 1976 Apr;116(4):1078–1083. [PubMed] [Google Scholar]
  9. Grewal A. S., Babiuk L. A. Induction, isolation and surface marker studies on bovine eosinophils. J Immunol Methods. 1979;25(1):65–75. doi: 10.1016/0022-1759(79)90167-4. [DOI] [PubMed] [Google Scholar]
  10. Hirashima M., Hayashi H. The mediation of tissue eosinophilia in hypersensitivity reaction. I. Isolation of two different chemotactic factors from DNP-Ascaris extract-induced skin lesion in guinea-pig. Immunology. 1976 Feb;30(2):203–212. [PMC free article] [PubMed] [Google Scholar]
  11. James S. L., Colley D. G. Eosinophi-mediated destruction of Schistosoma mansoni eggs in vitro. II. The role of cytophilic antibody. Cell Immunol. 1978 Jun;38(1):35–47. doi: 10.1016/0008-8749(78)90029-1. [DOI] [PubMed] [Google Scholar]
  12. Jones D. G., Kay A. B. The effect of anti-eosinophil serum on skin histamine replenishment following passive cutaneous anaphylaxis in the guinea-pig. Immunology. 1976 Sep;31(3):333–336. [PMC free article] [PubMed] [Google Scholar]
  13. Kazura J. W., Mahmoud A. A., Karb K. S., Warren K. S. The lymphokine eosinophil stimulation promoter and human schistosomiasis mansoni. J Infect Dis. 1975 Dec;132(6):702–706. doi: 10.1093/infdis/132.6.702. [DOI] [PubMed] [Google Scholar]
  14. Leber P. D., Milgrom M., Cohen S. Eosinophils in delayed hypersensitivity skin reaction sites. Immunol Commun. 1973;2(6):615–620. doi: 10.3109/08820137309022832. [DOI] [PubMed] [Google Scholar]
  15. Leu R. W., Eddleston A. L., Hadden J. W., Good R. A. Mechanism of action of migration inhibitory factor (MIF). I. Evidence for a receptor for MIF present on the peritoneal macrophage but not on the alveolar macrophage. J Exp Med. 1972 Sep 1;136(3):589–603. doi: 10.1084/jem.136.3.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Parish W. E. Eosinophilia. I. Eosinophilia in guinea-pigs mediated by passive anaphylaxis and by antigen-antibody complexes containing homologous IgG1a and IgG1b. Immunology. 1972 Jun;22(6):1087–1098. [PMC free article] [PubMed] [Google Scholar]
  18. Pelley R. P., Karp R., Mahmoud A. A., Warren K. S. Antigen dose response and specificity of production of the lymphokine eosinophil stimulation promoter. J Infect Dis. 1976 Sep;134(3):230–237. doi: 10.1093/infdis/134.3.230. [DOI] [PubMed] [Google Scholar]
  19. Taylor M. M., Burman C. J., Fantes K. H. Problems encountered in the preparation of migration inhibitory factor (MIF) and mitogenic factor (MIT) from phytomitogen-stimulated human peripheral lymphocytes and in the preparation of MIF from human lymphoid cell lines (LCL). Cell Immunol. 1975 Sep;19(1):41–57. doi: 10.1016/0008-8749(75)90290-7. [DOI] [PubMed] [Google Scholar]
  20. Wahl S. M., Wilton J. M., Rosenstreich D. L., Oppenheim J. J. The role of macrophages in the production of lymphokines by T and B lymphocytes. J Immunol. 1975 Apr;114(4):1296–1301. [PubMed] [Google Scholar]
  21. Ward P. A., Remold H. G., David J. R. Leukotactic factor produced by sensitized lymphocytes. Science. 1969 Mar 7;163(3871):1079–1081. doi: 10.1126/science.163.3871.1079. [DOI] [PubMed] [Google Scholar]
  22. Weller P. F., Dvorak J. A., Whitehouse W. C. Human eosinophil stimulation promoter lymphokine: production by antigen stimulated lymphocytes and assay with a new electro-optical technique. Cell Immunol. 1978 Sep 15;40(1):91–102. doi: 10.1016/0008-8749(78)90318-0. [DOI] [PubMed] [Google Scholar]
  23. Wilson A. B., Gurner B. W. Increased affinity of guinea pig thymocytes and thymus-dependent lymphocytes for papain-treated rabbit erythrocytes compared to untreated erythrocytes. J Immunol Methods. 1975 Jun;7(2-3):163–168. doi: 10.1016/0022-1759(75)90013-7. [DOI] [PubMed] [Google Scholar]
  24. Yamamoto S., Dunn C. J., Willoughby D. A. Studies on delayed hypersensitivity pleural exudates in guinea pigs. I. Demonstration of substances in the cell-free exudate which cause inhibition of mononuclear cell migration in vitro. Immunology. 1976 Apr;30(4):505–511. [PMC free article] [PubMed] [Google Scholar]
  25. Zeylemaker W. P., Roos M. T., Meyer C. J., Schellekens P. T., Eijsvoogel V. P. Separation of human lymphocyte subpopulations. I. Transformation characteristics of rosette-forming cells. Cell Immunol. 1974 Dec;14(3):346–358. doi: 10.1016/0008-8749(74)90184-1. [DOI] [PubMed] [Google Scholar]
  26. van den Berg W. B., Haasakker T. C., Bax J., Scheper R. J. Suppression of antibody-mediated accumulation of eosinophils in chronic inflammatory lesions by concomitant delayed hypersensitivity reactions. Immunology. 1980 Dec;41(4):981–988. [PMC free article] [PubMed] [Google Scholar]
  27. van den Berg W. B., Haasakker T. C., van Maarsseveen A. C., Scheper R. J. Chronic inflammatory reactions in the guinea-pig peritoneal cavity induced by continuous local PPD stimulation. Immune status dependency of the accumulation of lymphocytes and eosinophils. Immunology. 1980 Aug;40(4):673–681. [PMC free article] [PubMed] [Google Scholar]

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