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. 1981 Dec;44(4):661–669.

Androgen sensitivity and autoimmune disease. I. Influence of sex and testosterone on the humoral immune response of autoimmune and non-autoimmune mouse strains to sheep erythrocytes.

J I Morton, D A Weyant, B V Siegel, B Golding
PMCID: PMC1554987  PMID: 7033118

Abstract

Pre- and post-puberal NZB, DBA/2 and BALB/c mice showed no sex differences in primary IgM plaque-forming cell responses to sheep erythrocyte immunization. Orchiectomy increased and testosterone implants reduced antibody responses only if followed by sublethal irradiation suggesting that androgens may affect rapidly regenerating stem cells and/or their differentiating progeny. Strain differences in target organ sensitivity to androgen were not observed suggesting that NZB autoimmunity does not arise from a pathologic defect in androgen responsiveness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. E., Warner N. L. Ionizing radiation and the immune response. Adv Immunol. 1976;24:215–335. doi: 10.1016/s0065-2776(08)60331-4. [DOI] [PubMed] [Google Scholar]
  2. Cohn D. A. High sensitivity to androgen as a contributing factor in sex differences in the immune response. Arthritis Rheum. 1979 Nov;22(11):1218–1233. doi: 10.1002/art.1780221109. [DOI] [PubMed] [Google Scholar]
  3. Cohn D. A. Sensitivity to androgen. A possible factor in sex differences in the immune response. Clin Exp Immunol. 1979 Nov;38(2):218–227. [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  5. DRESSER D. W. Specific inhibition of antibody production. I. Protein-over loading paralysis. Immunology. 1962 Jan;5:161–168. [PMC free article] [PubMed] [Google Scholar]
  6. Eidinger D., Garrett T. J. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med. 1972 Nov 1;136(5):1098–1116. doi: 10.1084/jem.136.5.1098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fujii H., Nawa Y., Tsuchiya H., Matsuno K., Fukumoto T., Fukuda S., Kotani M. Effect of a single administration of testosterone on the immune response and lymphoid tissues in mice. Cell Immunol. 1975 Dec;20(2):315–326. doi: 10.1016/0008-8749(75)90108-2. [DOI] [PubMed] [Google Scholar]
  8. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Morton J. I., Siegel B. V. Response of NZB mice to foreign antigen and development of autoimmune disease. J Reticuloendothel Soc. 1969 Feb;6(1):78–93. [PubMed] [Google Scholar]
  10. NORINS L. C., HOLMES M. C. GLOBULINS OF NZB MOUSE ERYTHROCYTES. J Immunol. 1964 Dec;93:897–901. [PubMed] [Google Scholar]
  11. Raveche E. S., Tjio J. H., Boegel W., Steinberg A. D. Studies of the effects of sex hormones on autosomal and X-linked genetic control of induced and spontaneous antibody production. Arthritis Rheum. 1979 Nov;22(11):1177–1187. doi: 10.1002/art.1780221104. [DOI] [PubMed] [Google Scholar]
  12. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Siegel B. V., Brown M., Morton J. I. Detection of antinuclear antibodies in NZB and other mouse strains. Immunology. 1972 Mar;22(3):457–463. [PMC free article] [PubMed] [Google Scholar]
  14. Steinberg A. D., Melez K. A., Raveche E. S., Reeves J. P., Boegel W. A., Smathers P. A., Taurog J. D., Weinlein L., Duvic M. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 1979 Nov;22(11):1170–1176. doi: 10.1002/art.1780221103. [DOI] [PubMed] [Google Scholar]

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