Abstract
The present study was undertaken to investigate if the suppressed cell-mediated immune responses observed in dengue type 2 virus (DV)-infected mice could be due to the cytotoxic factor (CF) produced in the spleens of DV-infected mice. We have observed that CF given intravenously (i.v.) kills splenic cells and reduces the total cells in the spleen. Mice treated with CF have a significantly depressed immune response to sheep erythrocytes, viz. delayed-type-hypersensitivity as measured by footpad swelling reaction at 24 hr; Jerne's antibody plaque-forming cells in the spleen; and migration inhibition of spleen cells in presence of antigen. These findings are similar to those seen earlier in DV-infected mice.
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- Chaturvedi U. C., Bhargava A., Mathur A. Production of cytotoxic factor in the spleen of dengue virus-infected mice. Immunology. 1980 Aug;40(4):665–671. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Dalakoti H., Mathur A. Characterization of the cytotoxic factor produced in the spleen of dengue virus-infected mice. Immunology. 1980 Oct;41(2):387–392. [PMC free article] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon H. O., Mathur A. Control of in vitro and in vivo spread of coxsackievirus B4 infection by sensitized spleen cells and antibody. J Infect Dis. 1978 Aug;138(2):181–190. doi: 10.1093/infdis/138.2.181. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon P., Mathur A. Effect of immunosuppression on dengue virus infection in mice. J Gen Virol. 1977 Sep;36(3):449–458. doi: 10.1099/0022-1317-36-3-449. [DOI] [PubMed] [Google Scholar]
- Chaturvedi U. C., Tandon P., Mathur A., Kumar A. Host defence mechanisms against dengue virus infection of mice. J Gen Virol. 1978 May;39(2):293–302. doi: 10.1099/0022-1317-39-2-293. [DOI] [PubMed] [Google Scholar]
- Gately M. K., Mayer M. M., Henney C. S. Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for two pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells. Cell Immunol. 1976 Nov;27(1):82–93. doi: 10.1016/0008-8749(76)90156-8. [DOI] [PubMed] [Google Scholar]
- Jerne N. K., Nordin A. A. Plaque Formation in Agar by Single Antibody-Producing Cells. Science. 1963 Apr 26;140(3565):405–405. doi: 10.1126/science.140.3565.405. [DOI] [PubMed] [Google Scholar]
- Tandon P., Chaturvedi U. C., Mathur A. Dengue virus-induced thymus-derived suppressor cells in the spleen of mice. Immunology. 1979 Dec;38(4):653–658. [PMC free article] [PubMed] [Google Scholar]