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. 1981 Jul;43(3):401–407.

Immune components of the intestinal mucosae of ageing and protein deficient mice.

T S Lim, N Messiha, R R Watson
PMCID: PMC1555065  PMID: 6972910

Abstract

The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC activity which showed a drastic drop in activity at 75 weeks old than IgA which had only a slight decline in concentration at this age. The low protein diet has a greater suppressive effect on IgA concentration than on ADCC activity. As the duration of feeding low protein to the young mice increased, greater decline in IgA concentration in the intestine was observed. There was, however, no significant difference from the normal mice in ADCC activity and IgA concentration of aged and adult mice given short term (8 weeks) low protein diet.

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Selected References

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  1. Arnaud-Battandier F., Bundy B. M., O'Neill M., Bienenstock J., Nelson D. L. Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs. J Immunol. 1978 Sep;121(3):1059–1065. [PubMed] [Google Scholar]
  2. Becker M. J., Roubinian J., Feldmann J. L., Blackman M. A., Klajman A., Talal N. Age-related changes in antibody-dependent cell-mediated cytotoxicity in mouse spleen. Isr J Med Sci. 1979 Feb;15(2):147–150. [PubMed] [Google Scholar]
  3. Bell R. G., Hazell L. A. Influence of dietary protein restriction on immune competence. I. Effect on the capacity of cells from various lymphoid organs to induce graft-vs.-host reactions. J Exp Med. 1975 Jan 1;141(1):127–137. doi: 10.1084/jem.141.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brandtzaeg P. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells. J Immunol. 1974 Apr;112(4):1553–1559. [PubMed] [Google Scholar]
  5. Chandra R. K. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. doi: 10.1016/s0022-3476(72)80262-2. [DOI] [PubMed] [Google Scholar]
  6. DUNGAL N. Cancer in Iceland, with special reference to stomach cancer. Schweiz Z Pathol Bakteriol. 1955;18(4):550–556. doi: 10.1159/000160809. [DOI] [PubMed] [Google Scholar]
  7. Edelman R., Suskind R., Olson R. E., Sirisinha S. Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition. Lancet. 1973 Mar 10;1(7802):506–508. doi: 10.1016/s0140-6736(73)90326-7. [DOI] [PubMed] [Google Scholar]
  8. HAENSZEL W. Variation in incidence of and mortality from stomach cancer, with particular reference to the United States. J Natl Cancer Inst. 1958 Aug;21(2):213–262. [PubMed] [Google Scholar]
  9. Haffer K., Freeman M. J., Watson R. R. Effects of age on cellular immune responses in BALB/cJ mice: increase in antibody-dependent T lymphocyte mediated cytotoxicity. Mech Ageing Dev. 1979 Nov;11(4):279–285. doi: 10.1016/0047-6374(79)90007-1. [DOI] [PubMed] [Google Scholar]
  10. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  11. McMurray D. N., Rey H., Casazza L. J., Watson R. R. Effect of moderate malnutrition on concentrations of immunoglobulins and enzymes in tears and saliva of young Colombian children. Am J Clin Nutr. 1977 Dec;30(12):1944–1948. doi: 10.1093/ajcn/30.12.1944. [DOI] [PubMed] [Google Scholar]
  12. Menon M., Jaroslow R. N., Koesterer R. The decline of cell-mediated immunity in aging mice. J Gerontol. 1974 Sep;29(5):499–505. doi: 10.1093/geronj/29.5.499. [DOI] [PubMed] [Google Scholar]
  13. QUISENBERRY W. B. Stomach cancer in Hawaii. Med Arts Sci. 1955;9(3):74–81. [PubMed] [Google Scholar]
  14. Reinhardt M. C., Steward M. W. Antibody affinity and clearance function studies in high and low antibody affinity mice. The effect of protein deficiency. Immunology. 1979 Dec;38(4):735–739. [PMC free article] [PubMed] [Google Scholar]
  15. Ross M. H., Bras G. Influence of protein under- and overnutrition on spontaneous tumor prevalence in the rat. J Nutr. 1973 Jul;103(7):944–963. doi: 10.1093/jn/103.7.944. [DOI] [PubMed] [Google Scholar]
  16. Ross M. H., Bras G. Lasting influence of early caloric restriction on prevalence of neoplasms in the rat. J Natl Cancer Inst. 1971 Nov;47(5):1095–1113. [PubMed] [Google Scholar]
  17. Rudzik O., Bienenstock J. Isolation and characteristics of gut mucosal lymphocytes. Lab Invest. 1974 Mar;30(3):260–266. [PubMed] [Google Scholar]
  18. STRUDWICK W. J., EWING J. B., WHITE J. E. CARCINOMA OF THE STOMACH IN AMERICAN NEGROES. Surg Gynecol Obstet. 1964 Sep;119:580–582. [PubMed] [Google Scholar]
  19. Sanderson C. J., Clark I. A., Taylor G. A. Different effector cell types in antibody-dependent cell-mediated cytotoxicity. Nature. 1975 Jan 31;253(5490):376–377. doi: 10.1038/253376a0. [DOI] [PubMed] [Google Scholar]
  20. Watson R. R., Haffer K. Modifications of cell-mediated immune responses by moderate dietary protein stress in immunologically immature and mature BALB/c mice. Mech Ageing Dev. 1980 Mar;12(3):269–278. doi: 10.1016/0047-6374(80)90050-0. [DOI] [PubMed] [Google Scholar]
  21. Watson R. R., McMurray D. N. The effects of malnutrition on secretory and cellular immune processes. CRC Crit Rev Food Sci Nutr. 1979 Dec;12(2):113–159. doi: 10.1080/10408397909527275. [DOI] [PubMed] [Google Scholar]
  22. Weindruch R. H., Kristie J. A., Cheney K. E., Walford R. L. Influence of controlled dietary restriction on immunologic function and aging. Fed Proc. 1979 May;38(6):2007–2016. [PubMed] [Google Scholar]

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