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. 1981 Oct;44(2):249–255.

Further study on the humoral response of a highly-purified spleen-derived immunosuppressive peptide (SDIP).

N Duchange, L Millerioux, M Lenfant
PMCID: PMC1555223  PMID: 6975236

Abstract

Some biological properties of a highly-purified non-cytotoxic spleen-derived immunosuppressive peptide (SDIP) have been investigated. SDIP was shown to inhibit the primary anti-sheep red blood cell (SRBC) response at the last step of differentiation of the lymphocyte. In the present study we demonstrated that this response seemed to be T- and adherent spleen-cell dependent as no inhibition was noticed either in the response to TNP-LPS, a T-independent antigen, or in the response to SRBC in adherent spleen cell-depleted cultures. SDIP activity did not occur through an inhibition of splenocytes DNA synthesis since [3H]-thymidine ([3H]-TdR) incorporation was not modified in mitogen or allogenic stimulated cultures. Conversely, SDIP could act through a stimulation of a T-cell subset as a low specific increase of [3H]-TdR was noticed in cultured thymocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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