Abstract
Animals with electrolytic pre-optic and anterior hypothalamic (AHT) lesions show impaired mitogen-induced lymphocyte blastogenesis which is restored by removal of a population of spleen cells with macrophage-like properties. Although suppressor macrophages are detectable in normal and control rats, substantially more activity is present following AHT destruction. Abrogation of lymphocyte activation does not result from increased numbers of splenic macrophages. These data indicate that one mechanism by which neuroimmunomodulation occurs is by induction of a qualitative alteration in the function of naturally occurring suppressor macrophages.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartrop R. W., Luckhurst E., Lazarus L., Kiloh L. G., Penny R. Depressed lymphocyte function after bereavement. Lancet. 1977 Apr 16;1(8016):834–836. doi: 10.1016/s0140-6736(77)92780-5. [DOI] [PubMed] [Google Scholar]
- Bash J. A., Waksman B. H. The suppressive effect of immunization on the proliferative responses of rat T cells in vitro. J Immunol. 1975 Feb;114(2 Pt 2):782–787. [PubMed] [Google Scholar]
- Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
- Besedovsky H. O., del Rey A., Sorkin E., Da Prada M., Keller H. H. Immunoregulation mediated by the sympathetic nervous system. Cell Immunol. 1979 Dec;48(2):346–355. doi: 10.1016/0008-8749(79)90129-1. [DOI] [PubMed] [Google Scholar]
- Besedovsky H., Sorkin E., Felix D., Haas H. Hypothalamic changes during the immune response. Eur J Immunol. 1977 May;7(5):323–325. doi: 10.1002/eji.1830070516. [DOI] [PubMed] [Google Scholar]
- Camus D., Dessaint J. P., Fischer E., Capron A. Nonspecific suppressor cell activity and specific cellular unresponsiveness in rat schistosomiasis. Eur J Immunol. 1979 Apr;9(4):341–344. doi: 10.1002/eji.1830090417. [DOI] [PubMed] [Google Scholar]
- Cross R. J., Markesbery W. R., Brooks W. H., Roszman T. L. Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response. Brain Res. 1980 Aug 25;196(1):79–87. doi: 10.1016/0006-8993(80)90717-9. [DOI] [PubMed] [Google Scholar]
- Freed W. J., Perlow M. J., Karoum F., Seiger A., Olson L., Hoffer B. J., Wyatt R. J. Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: long-term behavioral, biochemical, and histochemical studies. Ann Neurol. 1980 Nov;8(5):510–519. doi: 10.1002/ana.410080508. [DOI] [PubMed] [Google Scholar]
- Glaser M., Kirchner H., Herberman R. B. Inhibition of in vitro lymphoproliferative responses to tumor-associated antigens by suppressor cells from rats bearing progressively growing Gross leukemia virus-induced tumors. Int J Cancer. 1975 Sep 15;16(3):384–393. doi: 10.1002/ijc.2910160305. [DOI] [PubMed] [Google Scholar]
- Hoffman P. M., Robbins D. S., Nolte M. T., Gibbs C. J., Jr, Gajdusek D. C. Cellular immunity in Guamanians with amyotrophic lateral sclerosis and Parkinsonism-dementia. N Engl J Med. 1978 Sep 28;299(13):680–685. doi: 10.1056/NEJM197809282991302. [DOI] [PubMed] [Google Scholar]
- Isaković K., Janković B. D. Neuro-endocrine correlates of immune response. II. Changes in the lymphatic organs of brain-lesioned rats. Int Arch Allergy Appl Immunol. 1973;45(3):373–384. doi: 10.1159/000231055. [DOI] [PubMed] [Google Scholar]
- Keller S. E., Stein M., Camerino M. S., Schleifer S. J., Sherman J. Suppression of lymphocyte stimulation by anterior hypothalamic lesions in the guinea pig. Cell Immunol. 1980 Jul 1;52(2):334–340. doi: 10.1016/0008-8749(80)90354-8. [DOI] [PubMed] [Google Scholar]
- Kruisbeek A. M., Zijlstra J., Zurcher C. Tumor-induced changes in T cell mitogen responses in rats: suppression of spleen and blood lymphocyte responses and enhancement of thymocyte responses. Eur J Immunol. 1978 Mar;8(3):200–206. doi: 10.1002/eji.1830080312. [DOI] [PubMed] [Google Scholar]
- Mattingly J. A., Eardley D. D., Kemp J. D., Gershon R. K. Induction of suppressor cells in rat spleen: influence of microbial stimulation. J Immunol. 1979 Mar;122(3):787–790. [PubMed] [Google Scholar]
- McDevitt H. O. Regulation of the immune response by the major histocompatibility system. N Engl J Med. 1980 Dec 25;303(26):1514–1517. doi: 10.1056/NEJM198012253032606. [DOI] [PubMed] [Google Scholar]
- Pierpaoli W., Baroni C., Fabris N., Sorkin E. Hormones and immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin. Immunology. 1969 Feb;16(2):217–230. [PMC free article] [PubMed] [Google Scholar]
- Roberts N. J., Jr Variability of results of lymphocyte transformation assays in normal human volunteers. Responses of mononuclear leukocytes to mitogen stimulation. Am J Clin Pathol. 1980 Feb;73(2):160–164. doi: 10.1093/ajcp/73.2.160. [DOI] [PubMed] [Google Scholar]
- Rode H. N., Uotila M., Gordon J. Regulation of the mixed leukocyte culture reaction by suppressor cells. Eur J Immunol. 1978 Mar;8(3):213–216. doi: 10.1002/eji.1830080314. [DOI] [PubMed] [Google Scholar]
- Roszman T. L., Brooks W. H., Markesbery W. R., Aziz G. J., Bigner D. D. Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus. J Neurosurg. 1981 Oct;55(4):554–559. doi: 10.3171/jns.1981.55.4.0554. [DOI] [PubMed] [Google Scholar]
- Shortman K., Williams N., Jackson H., Russell P., Byrt P., Diener E. The separation of different cell classes from lymphoid organs. IV. The separation of lymphocytes from phagocytes on glass bead columns, and its effect on subpopulations of lymphocytes and antibody-forming cells. J Cell Biol. 1971 Mar;48(3):566–579. doi: 10.1083/jcb.48.3.566. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solomon G. F. Emotions, stress, the central nervous system, and immunity. Ann N Y Acad Sci. 1969 Oct 14;164(2):335–343. doi: 10.1111/j.1749-6632.1969.tb14048.x. [DOI] [PubMed] [Google Scholar]
- Spry C. J. Inhibition of lymphocyte recirculation by stress and corticotropin. Cell Immunol. 1972 May;4(1):86–92. doi: 10.1016/0008-8749(72)90007-x. [DOI] [PubMed] [Google Scholar]
- Stein M., Schiavi R. C., Camerino M. Influence of brain and behavior on the immune system. Science. 1976 Feb 6;191(4226):435–440. doi: 10.1126/science.1108202. [DOI] [PubMed] [Google Scholar]
- Veit B. C., Feldman J. D. Altered lymphocyte functions in rats bearing syngeneic Moloney sarcoma tumors. I. Mitogen responses, mixed lymphocyte reactions (MLR) and mixed lymphocyte-tumor reactions (MLTR). J Immunol. 1976 Aug;117(2):646–654. [PubMed] [Google Scholar]
- Webb P. J., Brooks C. G., Baldwin R. W. Macrophage-like suppressor cells in rats. II. Evidence for a quantitative rather than a qualitative change in tumour-bearer animals. Cell Immunol. 1980 Jul 1;52(2):381–394. doi: 10.1016/0008-8749(80)90359-7. [DOI] [PubMed] [Google Scholar]
- Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]