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. 1982 Oct;47(2):345–349.

Cyclosporin-A inhibits accumulation of lymphocytes within lymph nodes.

A T Ali, J Morley, V M Rumjanek
PMCID: PMC1555442  PMID: 6981592

Abstract

The ability of cyclosporin-A (CS-A) to modify lymphocyte accumulation, seen in lymph nodes draining a site of antigen deposition, has been compared with the effect of other drugs known to affect lymphocytes and/or macrophages. CS-A markedly inhibited lymphocyte accumulation in a dose-related manner, whereas aspirin, BW755c (3 amino 1 [m (trifluoromethyl) phenyl] 2-pyrazoline) and hydrocortisone were without effect. Indomethacin produced inconclusive results. The time of CS-A administration was critical, the drug needing to be present before antigen inoculation, being ineffective if given 23 hr after antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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