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. 1982 Sep;47(1):85–90.

Concanavalin-induced suppressor cells: characterization on the basis of corticosteroid and radiation sensitivity.

G C Tsokos, C B Christian, J E Balow
PMCID: PMC1555494  PMID: 6214501

Abstract

Experiments were performed to examine whether the concanavalin A (Con A)- induced suppressor cells of several in vitro T- and B-lymphocyte functions constitute a functionally unique cell population. This study included simultaneous studies of three different assays of suppression of T- and B-lymphocyte functions. We found that Con-A-induced suppressor cells which inhibit the allogeneic mixed lymphocyte reaction (MLR) and the pokeweed mitogen-induced, plaque-forming cell (PEC) response are radiation sensitive at doses greater than 1000 rad, but corticosteroid resistant, while those suppressing allogeneic cell-mediated lympholysis (CML) are both radiation and corticosteroid resistant. These studies indicate either that Con-A-induced suppressor cells include heterogeneous populations which are differentially sensitive to corticosteroids and radiation, or that functionally distinct suppressor mechanisms are variably sensitive to these agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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