Skip to main content
Immunology logoLink to Immunology
. 1982 Nov;47(3):497–501.

Thymosin: an immunomodulator of antibody production in man.

A Górski, G Korczak-Kowalska, M Nowaczyk, Z Gaciong, E Skopińska-Rózewska
PMCID: PMC1555552  PMID: 6215339

Abstract

Thymosin (TFX) stimulates polyclonal antibody synthesis of human peripheral blood, lymph node and spleen lymphocytes. This stimulation is observed only with T-cell-dependent polyclonal activators of immunoglobulin production and its mechanism appears to be associated with TFX-induced activation of T-helper cells. On the other hand, antibody production in vitro of lymphocytes already involved in high humoral responses is inhibited by thymosin. TFX has similar activity both in vitro and in vivo.

Full text

PDF
497

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berry R. W., Arch S. Activation of neurosecretory cells enhances their synthesis of secretory protein. Brain Res. 1981 Jun 29;215(1-2):115–123. doi: 10.1016/0006-8993(81)90495-9. [DOI] [PubMed] [Google Scholar]
  2. Górski A., Skotnicki A. B., Gaciong Z., Korczak G. The effect of calf thymus extract (TFX) on human and mouse hemopoiesis. Thymus. 1981 Sep;3(3):129–141. [PubMed] [Google Scholar]
  3. Hodinka L., Merétey K., Zahumenszky Z., Bozsóky S. Levamisole: possibilities of immunomodulation in the basic treatment of rheumatoid arthritis. Clinical and immunological observations in a one-year decaris treatment of rheumatoid arthritis patients. Ther Hung. 1981;29(4):162–169. [PubMed] [Google Scholar]
  4. Horowitz S., Borcherding W., Moorthy A. V., Chesney R., Schulte-Wisserman H., Hong R. Induction of suppressor T cells in systemic lupus erythematosus by thymosin and cultured thymic epithelium. Science. 1977 Sep 2;197(4307):999–1001. doi: 10.1126/science.302032. [DOI] [PubMed] [Google Scholar]
  5. Kamiński M. J., Nowacyk M., Skopińska-Rozewska E., Kamińska G., Bem W. Human peripheral blood T lymphocyte subpopulations isolated on the basis of their affinity for sheep red blood cells differ in angiogenesis-inducing capability. Clin Exp Immunol. 1981 Nov;46(2):327–331. [PMC free article] [PubMed] [Google Scholar]
  6. Kaufman D. B. Maturational effects of thymic hormones on human helper and suppressor T cells: effects of FTS ('Facteur Thymique Sérique') and thymosin. Clin Exp Immunol. 1980 Mar;39(3):722–727. [PMC free article] [PubMed] [Google Scholar]
  7. Miyawaki T., Kubo M., Nagaoki T., Moriya N., Yokoi T., Mukai M., Taniguchi N. Developmental changes in humoral suppressor activity released from concanavalin A-stimulated human lymphocytes on B cell differentiation. J Immunol. 1981 May;126(5):1720–1723. [PubMed] [Google Scholar]
  8. Mutchnick M. G., Lederman H. M., Missirian A., Johnson A. G. In vitro synthesis of IgG by peripheral blood lymphocytes in chronic liver disease. Clin Exp Immunol. 1981 Feb;43(2):370–375. [PMC free article] [PubMed] [Google Scholar]
  9. Sredni B., Gopas J., Rozenszajn L. A. Induction of B lymphocyte colony growth in vitro by thymus-derived stimulating factor. Eur J Immunol. 1978 Oct;8(10):681–685. doi: 10.1002/eji.1830081002. [DOI] [PubMed] [Google Scholar]
  10. Wolf R. E., Goldstein A. L., Ziff M. Suppression by thymosin of pokeweed mitogen-induced differentiation of human B cells. Clin Immunol Immunopathol. 1978 Nov;11(3):303–306. doi: 10.1016/0090-1229(78)90054-5. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES