Abstract
1. Studies are reported of total intestinal perfusion in man in which data relating to the absorptive capacity for water and sodium, flow rate transit time and intestinal volume have been obtained.
2. A 'bolus' of radiosodium added to the steady-state perfusion has allowed measurement of bidirectional fluxes of sodium ion across the mucosa to be determined.
3. The values obtained agree closely with those that can be predicted from small segmental studies reported in the literature.
4. Increasing absorption capacity with increasing flow rate does not seem to reflect a true increase in absorption per unit of intestine but rather a progression to more nearly continuous flow conditions.
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- BORGSTROM B., DAHLQVIST A., LUNDH G., SJOVALL J. Studies of intestinal digestion and absorption in the human. J Clin Invest. 1957 Oct;36(10):1521–1536. doi: 10.1172/JCI103549. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FISHER R. B. The absorption of water and of some small solute molecules from the isolated small intestine of the rat. J Physiol. 1955 Dec 29;130(3):655–664. doi: 10.1113/jphysiol.1955.sp005433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FORDTRAN J. S., LEVITAN R., BIKERMAN V., BURROWS B. A., INGELFINGER F. J. The kinetics of water absorption in the human intestine. Trans Assoc Am Physicians. 1961;74:195–206. [PubMed] [Google Scholar]
- LEE P. R., CODE C. F., SCHOLER J. F. The influence of varying concentrations of sodium chloride on the rate of absorption of water from the stomach and small bowel of human beings. Gastroenterology. 1955 Dec;29(6):1008–1016. [PubMed] [Google Scholar]
- LEVITAN R., FORDTRAN J. S., BURROWS B. A., INGELFINGER F. J. Water and salt absorption in the human colon. J Clin Invest. 1962 Sep;41:1754–1759. doi: 10.1172/JCI104634. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMYTH D. H., TAYLOR C. B. Transfer of water and solutes by an in vitro intestinal preparation. J Physiol. 1957 May 23;136(3):632–648. doi: 10.1113/jphysiol.1957.sp005788. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VAUGHAN B. E. Intestinal electrolyte absorption by parallel determination of unidirectional sodium and water transfers. Am J Physiol. 1960 Jun;198:1235–1244. doi: 10.1152/ajplegacy.1960.198.6.1235. [DOI] [PubMed] [Google Scholar]