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. 1968 Mar;195(1):157–183. doi: 10.1113/jphysiol.1968.sp008453

Heat work and phosphorylcreatine break-down in muscle

D R Wilkie
PMCID: PMC1557910  PMID: 5639798

Abstract

1. A new instrument, the integrating thermopile, is described for measuring the total quantity of heat produced during muscular contraction.

2. This instrument has been used to investigate the relation between change of enthalpy (- (heat produced + work produced)) and break-down of phosphorylcreatine (ΔPC) in iodoacetate-poisoned frog sartorii at 0° C. In a variety of different types of contraction—series of isometric twitches, isometric tetani, contractions with positive and with negative work—the relation between enthalpy change and ΔPC was always the same, and corresponded to an in vivo molar enthalpy change (ΔH) of -11·0 ± 0·23 (S.E.; n = 52) kcal/mole.

3. This value of ΔH is used to estimate the in vivo ΔH for ATP splitting and also the number of rephosphorylations to be expected per hexose unit oxidized by normal unpoisoned muscle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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