Abstract
The effects of the synthetic cannabinoid WIN 55,212-2 on forskolin-stimulated and basal adenosine 3′ : 5′-cyclic monophosphate (cyclic AMP) accumulation in globus pallidus slices were investigated. WIN 55,212-2 caused a concentration-dependent decrease in forskolin-stimulated cyclic AMP accumulation in globus pallidus slices (maximum inhibition 36% for 30 μM). This effect was blocked by the cannabinoid receptor antagonist SR 141716A (100 μM). WIN 55,212-2 alone caused a concentration-dependent increase in cyclic AMP levels in unstimulated slices (maximum increase 52.6% for 100 μM). This effect was also blocked by SR 141716A (100 μM). In either forskolin-stimulated or unstimulated conditions SR 1417161A (100 μM) did not affect cyclic AMP levels.
Keywords: Cannabinoids; CB1 receptor; globus pallidus; cyclic AMP; WIN 55,212-2; SR 141716A
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