Abstract
The P2Y2 nucleotide receptor has previously been shown to stimulate phosphoinositide breakdown. We now show that, when P2Y2 receptors are heterologously expressed by cRNA injection into dissociated rat sympathetic neurones, activation of these receptors by uridine 5′-triphosphate (UTP) or adenosine 5′-triphosphate (ATP) inhibits the N-type voltage-gated calcium current by ∼65%, with an IC50 of 0.5 μM. Thus, the same molecular species of nucleotide receptor can link to two different effector pathways.
Keywords: Nucleotide receptors, P2 receptors, uridine triphosphate, adenosine triphosphate, sympathetic neurones, calcium currents
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