Evidence that [Phe¹ ψ(CH₂-NH)Gly²]nociceptin-(1-13)-NH₂, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord

Abstract

[Phe¹ ψ(CH₂-NH)Gly²]nociceptin-(1-13)-NH₂, a pseudopeptide analogue of nociceptin is an antagonist in peripheral assays. Here, using in vivo electrophysiological recordings of dorsal horn neurones, [Phe¹ ψ(CH₂-NH)Gly²]nociceptin-(1-13)-NH₂ appears to have agonist activity after spinal administration. The noxious evoked activity of the neurones was inhibited by [Phe¹ ψ(CH₂-NH)Gly²]nociceptin-(1-13)-NH₂, which was as potent as nociceptin itself.

Full Text

The Full Text of this article is available as a PDF (212.6 KB).