Abstract
Exposure to environmental tobacco smoke (ETS) among individuals who have never smoked tobacco products has been well established as a risk factor for lung cancer. Most of the epidemiologic evidence for this association has come from studies of exposure to a spouse who smokes. Fewer studies have explicitly evaluated this risk relationship for workplace sources of ETS exposure. These are reviewed here in the context of study design issues and their contributions to the overall evidence for risks of ETS exposure in the workplace. Although most studies have low power to detect workplace risk estimates in the modest range suggested by the larger studies, risk estimates tend to be consistent with those for exposure from a smoking spouse.
Full text
PDF







Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Akiba S., Kato H., Blot W. J. Passive smoking and lung cancer among Japanese women. Cancer Res. 1986 Sep;46(9):4804–4807. [PubMed] [Google Scholar]
- Alavanja M. C., Brownson R. C., Lubin J. H., Berger E., Chang J., Boice J. D., Jr Residential radon exposure and lung cancer among nonsmoking women. J Natl Cancer Inst. 1994 Dec 21;86(24):1829–1837. doi: 10.1093/jnci/86.24.1829. [DOI] [PubMed] [Google Scholar]
- Blot W. J., McLaughlin J. K. Passive smoking and lung cancer risk: what is the story now? J Natl Cancer Inst. 1998 Oct 7;90(19):1416–1417. doi: 10.1093/jnci/90.19.1416. [DOI] [PubMed] [Google Scholar]
- Boffetta P., Agudo A., Ahrens W., Benhamou E., Benhamou S., Darby S. C., Ferro G., Fortes C., Gonzalez C. A., Jöckel K. H. Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. J Natl Cancer Inst. 1998 Oct 7;90(19):1440–1450. doi: 10.1093/jnci/90.19.1440. [DOI] [PubMed] [Google Scholar]
- Brownson R. C., Alavanja M. C., Hock E. T., Loy T. S. Passive smoking and lung cancer in nonsmoking women. Am J Public Health. 1992 Nov;82(11):1525–1530. doi: 10.2105/ajph.82.11.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brownson R. C., Reif J. S., Keefe T. J., Ferguson S. W., Pritzl J. A. Risk factors for adenocarcinoma of the lung. Am J Epidemiol. 1987 Jan;125(1):25–34. doi: 10.1093/oxfordjournals.aje.a114509. [DOI] [PubMed] [Google Scholar]
- Cardenas V. M., Thun M. J., Austin H., Lally C. A., Clark W. S., Greenberg R. S., Heath C. W., Jr Environmental tobacco smoke and lung cancer mortality in the American Cancer Society's Cancer Prevention Study. II. Cancer Causes Control. 1997 Jan;8(1):57–64. doi: 10.1023/a:1018483121625. [DOI] [PubMed] [Google Scholar]
- Cress R. D., Holly E. A., Aston D. A., Ahn D. K., Kristiansen J. J. Characteristics of women nonsmokers exposed to passive smoke. Prev Med. 1994 Jan;23(1):40–47. doi: 10.1006/pmed.1994.1006. [DOI] [PubMed] [Google Scholar]
- Fontham E. T., Correa P., Reynolds P., Wu-Williams A., Buffler P. A., Greenberg R. S., Chen V. W., Alterman T., Boyd P., Austin D. F. Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study. JAMA. 1994 Jun 8;271(22):1752–1759. [PubMed] [Google Scholar]
- Fontham E. T., Correa P., WuWilliams A., Reynolds P., Greenberg R. S., Buffler P. A., Chen V. W., Boyd P., Alterman T., Austin D. F. Lung cancer in nonsmoking women: a multicenter case-control study. Cancer Epidemiol Biomarkers Prev. 1991 Nov-Dec;1(1):35–43. [PubMed] [Google Scholar]
- Friedman G. D., Petitti D. B., Bawol R. D. Prevalence and correlates of passive smoking. Am J Public Health. 1983 Apr;73(4):401–405. doi: 10.2105/ajph.73.4.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garfinkel L., Auerbach O., Joubert L. Involuntary smoking and lung cancer: a case-control study. J Natl Cancer Inst. 1985 Sep;75(3):463–469. [PubMed] [Google Scholar]
- Hammond S. K., Sorensen G., Youngstrom R., Ockene J. K. Occupational exposure to environmental tobacco smoke. JAMA. 1995 Sep 27;274(12):956–960. [PubMed] [Google Scholar]
- Hirayama T. Cancer mortality in nonsmoking women with smoking husbands based on a large-scale cohort study in Japan. Prev Med. 1984 Nov;13(6):680–690. doi: 10.1016/s0091-7435(84)80017-1. [DOI] [PubMed] [Google Scholar]
- Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study from Japan. Br Med J (Clin Res Ed) 1981 Jan 17;282(6259):183–185. doi: 10.1136/bmj.282.6259.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard D. J., Ota R. B., Briggs L. A., Hampton M., Pritsos C. A. Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2'-deoxyguanosine. Cancer Epidemiol Biomarkers Prev. 1998 Feb;7(2):141–146. [PubMed] [Google Scholar]
- Janerich D. T., Thompson W. D., Varela L. R., Greenwald P., Chorost S., Tucci C., Zaman M. B., Melamed M. R., Kiely M., McKneally M. F. Lung cancer and exposure to tobacco smoke in the household. N Engl J Med. 1990 Sep 6;323(10):632–636. doi: 10.1056/NEJM199009063231003. [DOI] [PubMed] [Google Scholar]
- Jöckel K. H., Pohlabeln H., Ahrens W., Krauss M. Environmental tobacco smoke and lung cancer. Epidemiology. 1998 Nov;9(6):672–675. [PubMed] [Google Scholar]
- Kabat G. C., Stellman S. D., Wynder E. L. Relation between exposure to environmental tobacco smoke and lung cancer in lifetime nonsmokers. Am J Epidemiol. 1995 Jul 15;142(2):141–148. doi: 10.1093/oxfordjournals.aje.a117612. [DOI] [PubMed] [Google Scholar]
- Kabat G. C., Wynder E. L. Lung cancer in nonsmokers. Cancer. 1984 Mar 1;53(5):1214–1221. doi: 10.1002/1097-0142(19840301)53:5<1214::aid-cncr2820530532>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- Kalandidi A., Katsouyanni K., Voropoulou N., Bastas G., Saracci R., Trichopoulos D. Passive smoking and diet in the etiology of lung cancer among non-smokers. Cancer Causes Control. 1990 Jul;1(1):15–21. doi: 10.1007/BF00053179. [DOI] [PubMed] [Google Scholar]
- Ko Y. C., Lee C. H., Chen M. J., Huang C. C., Chang W. Y., Lin H. J., Wang H. Z., Chang P. Y. Risk factors for primary lung cancer among non-smoking women in Taiwan. Int J Epidemiol. 1997 Feb;26(1):24–31. doi: 10.1093/ije/26.1.24. [DOI] [PubMed] [Google Scholar]
- Lam T. H., Kung I. T., Wong C. M., Lam W. K., Kleevens J. W., Saw D., Hsu C., Seneviratne S., Lam S. Y., Lo K. K. Smoking, passive smoking and histological types in lung cancer in Hong Kong Chinese women. Br J Cancer. 1987 Nov;56(5):673–678. doi: 10.1038/bjc.1987.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee P. N., Chamberlain J., Alderson M. R. Relationship of passive smoking to risk of lung cancer and other smoking-associated diseases. Br J Cancer. 1986 Jul;54(1):97–105. doi: 10.1038/bjc.1986.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Liu Q., Sasco A. J., Riboli E., Hu M. X. Indoor air pollution and lung cancer in Guangzhou, People's Republic of China. Am J Epidemiol. 1993 Jan 15;137(2):145–154. doi: 10.1093/oxfordjournals.aje.a116654. [DOI] [PubMed] [Google Scholar]
- Liu Z. Y., He X. Z., Chapman R. S. Smoking and other risk factors for lung cancer in Xuanwei, China. Int J Epidemiol. 1991 Mar;20(1):26–31. doi: 10.1093/ije/20.1.26. [DOI] [PubMed] [Google Scholar]
- Matanoski G., Kanchanaraksa S., Lantry D., Chang Y. Characteristics of nonsmoking women in NHANES I and NHANES I epidemiologic follow-up study with exposure to spouses who smoke. Am J Epidemiol. 1995 Jul 15;142(2):149–157. doi: 10.1093/oxfordjournals.aje.a117613. [DOI] [PubMed] [Google Scholar]
- Miller G. H. Cancer, passive smoking and nonemployed and employed wives. West J Med. 1984 Apr;140(4):632–635. [PMC free article] [PubMed] [Google Scholar]
- Morabia A., Bernstein M., Héritier S., Khatchatrian N. Relation of breast cancer with passive and active exposure to tobacco smoke. Am J Epidemiol. 1996 May 1;143(9):918–928. doi: 10.1093/oxfordjournals.aje.a008835. [DOI] [PubMed] [Google Scholar]
- Nyberg F., Agrenius V., Svartengren K., Svensson C., Pershagen G. Environmental tobacco smoke and lung cancer in nonsmokers: does time since exposure play a role? Epidemiology. 1998 May;9(3):301–308. [PubMed] [Google Scholar]
- Parsons W. D., Carmella S. G., Akerkar S., Bonilla L. E., Hecht S. S. A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke. Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):257–260. [PubMed] [Google Scholar]
- Repace J. L., Jinot J., Bayard S., Emmons K., Hammond S. K. Air nicotine and saliva cotinine as indicators of workplace passive smoking exposure and risk. Risk Anal. 1998 Feb;18(1):71–83. doi: 10.1111/j.1539-6924.1998.tb00917.x. [DOI] [PubMed] [Google Scholar]
- Reynolds P., von Behren J., Fontham E. T., Correa P., Wu A., Buffler P. A., Greenberg R. S. Occupational exposure to environmental tobacco smoke. JAMA. 1996 Feb 14;275(6):441–442. doi: 10.1001/jama.1996.03530300025019. [DOI] [PubMed] [Google Scholar]
- Riboli E., Preston-Martin S., Saracci R., Haley N. J., Trichopoulos D., Becher H., Burch J. D., Fontham E. T., Gao Y. T., Jindal S. K. Exposure of nonsmoking women to environmental tobacco smoke: a 10-country collaborative study. Cancer Causes Control. 1990 Nov;1(3):243–252. doi: 10.1007/BF00117476. [DOI] [PubMed] [Google Scholar]
- Sandler D. P., Everson R. B., Wilcox A. J. Passive smoking in adulthood and cancer risk. Am J Epidemiol. 1985 Jan;121(1):37–48. doi: 10.1093/oxfordjournals.aje.a113980. [DOI] [PubMed] [Google Scholar]
- Shimizu H., Morishita M., Mizuno K., Masuda T., Ogura Y., Santo M., Nishimura M., Kunishima K., Karasawa K., Nishiwaki K. A case-control study of lung cancer in nonsmoking women. Tohoku J Exp Med. 1988 Apr;154(4):389–397. doi: 10.1620/tjem.154.389. [DOI] [PubMed] [Google Scholar]
- Sidney S., Caan B. J., Friedman G. D. Dietary intake of carotene in nonsmokers with and without passive smoking at home. Am J Epidemiol. 1989 Jun;129(6):1305–1309. doi: 10.1093/oxfordjournals.aje.a115250. [DOI] [PubMed] [Google Scholar]
- Siegel M. Involuntary smoking in the restaurant workplace. A review of employee exposure and health effects. JAMA. 1993 Jul 28;270(4):490–493. [PubMed] [Google Scholar]
- Stockwell H. G., Goldman A. L., Lyman G. H., Noss C. I., Armstrong A. W., Pinkham P. A., Candelora E. C., Brusa M. R. Environmental tobacco smoke and lung cancer risk in nonsmoking women. J Natl Cancer Inst. 1992 Sep 16;84(18):1417–1422. doi: 10.1093/jnci/84.18.1417. [DOI] [PubMed] [Google Scholar]
- Svensson C., Pershagen G., Klominek J. Smoking and passive smoking in relation to lung cancer in women. Acta Oncol. 1989;28(5):623–629. doi: 10.3109/02841868909092282. [DOI] [PubMed] [Google Scholar]
- Thornton A., Lee P., Fry J. Differences between smokers, ex-smokers, passive smokers and non-smokers. J Clin Epidemiol. 1994 Oct;47(10):1143–1162. doi: 10.1016/0895-4356(94)90101-5. [DOI] [PubMed] [Google Scholar]
- Wald N., Ritchie C. Validation of studies on lung cancer in non-smokers married to smokers. Lancet. 1984 May 12;1(8385):1067–1067. doi: 10.1016/s0140-6736(84)91467-3. [DOI] [PubMed] [Google Scholar]
- Wells A. J. Lung cancer from passive smoking at work. Am J Public Health. 1998 Jul;88(7):1025–1029. doi: 10.2105/ajph.88.7.1025. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wu-Williams A. H., Dai X. D., Blot W., Xu Z. Y., Sun X. W., Xiao H. P., Stone B. J., Yu S. F., Feng Y. P., Ershow A. G. Lung cancer among women in north-east China. Br J Cancer. 1990 Dec;62(6):982–987. doi: 10.1038/bjc.1990.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wu A. H., Henderson B. E., Pike M. C., Yu M. C. Smoking and other risk factors for lung cancer in women. J Natl Cancer Inst. 1985 Apr;74(4):747–751. [PubMed] [Google Scholar]
- Zaridze D., Maximovitch D., Zemlyanaya G., Aitakov Z. N., Boffetta P. Exposure to environmental tobacco smoke and risk of lung cancer in non-smoking women from Moscow, Russia. Int J Cancer. 1998 Jan 30;75(3):335–338. doi: 10.1002/(sici)1097-0215(19980130)75:3<335::aid-ijc1>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]