Abstract
In studies on the relation between indoor mold exposure and symptoms/disease, the exposure should be described in terms of biomass and not viability. This paper reviews field studies in which (1--> 3)-ss-d-glucan was measured as a marker of biomass and was related to the extent of symptoms and measures of inflammation among exposed subjects. Increased levels of (1-->3)-ss-d-glucan were related to an increased extent of symptoms and markers of inflammation. The data suggest that (1-->3)-ss-d-glucan can be used as a risk marker in indoor environments.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burge S., Hedge A., Wilson S., Bass J. H., Robertson A. Sick building syndrome: a study of 4373 office workers. Ann Occup Hyg. 1987;31(4A):493–504. doi: 10.1093/annhyg/31.4a.493. [DOI] [PubMed] [Google Scholar]
- Husman T. Health effects of indoor-air microorganisms. Scand J Work Environ Health. 1996 Feb;22(1):5–13. doi: 10.5271/sjweh.103. [DOI] [PubMed] [Google Scholar]
- Miller J. D., Young J. C. The use of ergosterol to measure exposure to fungal propagules in indoor air. Am Ind Hyg Assoc J. 1997 Jan;58(1):39–43. doi: 10.1080/15428119791013062. [DOI] [PubMed] [Google Scholar]
- Rylander R. Airborne (1-->3)-beta-D-glucan and airway disease in a day-care center before and after renovation. Arch Environ Health. 1997 Jul-Aug;52(4):281–285. doi: 10.1080/00039899709602199. [DOI] [PubMed] [Google Scholar]
- Rylander R., Norrhall M., Engdahl U., Tunsäter A., Holt P. G. Airways inflammation, atopy, and (1--> 3)-beta-D-glucan exposures in two schools. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1685–1687. doi: 10.1164/ajrccm.158.5.9712139. [DOI] [PubMed] [Google Scholar]
- Tamura H., Arimoto Y., Tanaka S., Yoshida M., Obayashi T., Kawai T. Automated kinetic assay for endotoxin and (1-->3)-beta-D-glucan in human blood. Clin Chim Acta. 1994 Apr;226(1):109–112. doi: 10.1016/0009-8981(94)90110-4. [DOI] [PubMed] [Google Scholar]
- Thorn J., Rylander R. Airways inflammation and glucan in a rowhouse area. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1798–1803. doi: 10.1164/ajrccm.157.6.9706081. [DOI] [PubMed] [Google Scholar]