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. 1999 Oct;107(Suppl 5):807–810. doi: 10.1289/ehp.99107s5807

Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.

L M Bagenstose 1, P Salgame 1, M Monestier 1
PMCID: PMC1566235  PMID: 10502547

Abstract

Experimental models of chemically induced autoimmunity have contributed to our understanding of the development of autoimmune diseases in humans. Heavy metals such as mercury induce a dramatic activation of the immune system and autoantibody production in genetically susceptible rats and mice. This autoimmune syndrome is dependent on T cells, which are important for B-cell activation and cytokine secretion. Several studies have focused on the roles of T-helper (Th)1 and Th2 cells and their respective cytokines in the pathogenesis of mercury-induced disease. This article reviews recent studies that have examined the patterns of cytokine gene expression and where investigators have manipulated the Th1 and Th2 responses that occur during mercury-induced autoimmunity. Finally, we will discuss some biochemical/molecular mechanisms by which heavy metals may induce cytokine gene expression.

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Selected References

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