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. 1999 May;107(Suppl 2):259–271. doi: 10.1289/ehp.99107s2259

Occupational cancer in Italy.

E Merler 1, P Vineis 1, D Alhaique 1, L Miligi 1
PMCID: PMC1566274  PMID: 10350509

Abstract

This article is a discussion of occupational cancer in Italy. The introduction provides the necessary context of Italian industrialization and occupational health regulation. This is followed by a review of Italian epidemiologic studies of occupational cancer risks considered in terms of relative measures of risk and attributable risk of carcinogenic agents or exposure circumstances. We attempt to establish the number of workers exposed to carcinogens in Italy and the intensity of their exposures. Finally, the Italian system of compensation for occupational cancer is discussed. Several cohort and case-control studies have addressed the issue of occupational risks, mostly among male workers. The results of these studies suggest that the growing incidence of and mortality by mesothelioma is explained by the widespread and intense exposure to asbestos in some Italian industrial settings. A high attributable risk of lung tumors among male populations in industrial areas of northern Italy is explained by occupational exposures. However, insufficient data are available for clear definition of the extent and intensity of occupational exposure to carcinogenic substances. In Italy, we must prioritize and maximize resources in occupational cancer epidemiology and revitalize the role of national institutions. Recent legislation has established new regulations on the handling of carcinogenic substances in industrial settings, a new list of occupational diseases, and a national registry of mesothelioma linked to asbestos exposure. These legislative changes are expected to have positive effects.

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Selected References

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  1. Alberghini V., Luberto F., Gobba F., Morelli C., Gori E., Tomesani N. Mortality among male farmers licensed to use pesticides. Med Lav. 1991 Jan-Feb;82(1):18–24. [PubMed] [Google Scholar]
  2. Barbone F., Franceschi S., Talamini R., Bidoli E., La Vecchia C. Occupation and bladder cancer in Pordenone (north-east Italy): a case-control study. Int J Epidemiol. 1994 Feb;23(1):58–65. doi: 10.1093/ije/23.1.58. [DOI] [PubMed] [Google Scholar]
  3. Battista G., Belli S., Carboncini F., Comba P., Levante G., Sartorelli P., Strambi F., Valentini F., Axelson O. Mortality among pyrite miners with low-level exposure to radon daughters. Scand J Work Environ Health. 1988 Oct;14(5):280–285. doi: 10.5271/sjweh.1919. [DOI] [PubMed] [Google Scholar]
  4. Battista G., Cavallucci F., Comba P., Quercia A., Vindigni C., Sartorelli E. A case-referent study on nasal cancer and exposure to wood dust in the province of Siena, Italy. Scand J Work Environ Health. 1983 Feb;9(1):25–29. doi: 10.5271/sjweh.2446. [DOI] [PubMed] [Google Scholar]
  5. Becherini R., Seniori Costantini A., Benelli R., Calistri S., Gasperini M. M., Gavazzi M., Masala G., Merler E., Monechi V., Nannini R. Tumori delle vie urinarie escretrici negli addetti all'industria tessile nell'area pratese. Med Lav. 1991 Nov-Dec;82(6):492–503. [PubMed] [Google Scholar]
  6. Bellander T., Merler E., Ceccarelli F., Boffetta P. Historical exposure to inorganic mercury at the smelter works of Abbadia San Salvatore, Italy. Ann Occup Hyg. 1998 Feb;42(2):81–90. doi: 10.1016/s0003-4878(97)00052-5. [DOI] [PubMed] [Google Scholar]
  7. Belli S., Bertazzi P. A., Comba P., Foà V., Maltoni C., Masina A., Pirastu R., Reggiani A., Vigotti M. A. A cohort study on vinyl chloride manufacturers in Italy: study design and preliminary results. Cancer Lett. 1987 Jun;35(3):253–261. doi: 10.1016/0304-3835(87)90127-3. [DOI] [PubMed] [Google Scholar]
  8. Belli S., Comba P., De Santis M., Grignoli M., Sasco A. J. Mortality study of workers employed by the Italian National Institute of Health, 1960-1989. Scand J Work Environ Health. 1992 Feb;18(1):64–67. doi: 10.5271/sjweh.1607. [DOI] [PubMed] [Google Scholar]
  9. Bernardinelli L., de Marco R., Tinelli C. Cancer mortality in an Italian rubber factory. Br J Ind Med. 1987 Mar;44(3):187–191. doi: 10.1136/oem.44.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bertazzi P. A., Pesatori A. C., Radice L., Zocchetti C., Vai T. Exposure to formaldehyde and cancer mortality in a cohort of workers producing resins. Scand J Work Environ Health. 1986 Oct;12(5):461–468. doi: 10.5271/sjweh.2111. [DOI] [PubMed] [Google Scholar]
  11. Bertazzi P. A., Pesatori A. C., Zocchetti C., Latocca R. Mortality study of cancer risk among oil refinery workers. Int Arch Occup Environ Health. 1989;61(4):261–270. doi: 10.1007/BF00381424. [DOI] [PubMed] [Google Scholar]
  12. Bertazzi P. A., Pesatori A., Guercilena S., Consonni D., Zocchetti C. Rischio cancerogeno per i produttori di resine esposti a formaldeide: estensione del follow-up. Med Lav. 1989 Mar-Apr;80(2):111–122. [PubMed] [Google Scholar]
  13. Bertazzi P. A., Riboldi L., Pesatori A., Radice L., Zocchetti C. Cancer mortality of capacitor manufacturing workers. Am J Ind Med. 1987;11(2):165–176. doi: 10.1002/ajim.4700110206. [DOI] [PubMed] [Google Scholar]
  14. Bertazzi P. A., Zocchetti C. A mortality study of newspaper printing workers. Am J Ind Med. 1980;1(1):85–97. doi: 10.1002/ajim.4700010110. [DOI] [PubMed] [Google Scholar]
  15. Bertazzi P. A., Zocchetti C., Pesatori A., Radice L., Riboldi L. Mortalità per tumori in una coorte di produttori di fibre vetrose. Med Lav. 1984 Sep-Oct;75(5):339–358. [PubMed] [Google Scholar]
  16. Bertazzi P. A., Zocchetti C., Terzaghi G. F., Riboldi L., Guercilena S., Beretta F. Rischio cancerogeno nella produzione di vernici. Uno studio di mortalità. Med Lav. 1981 Nov-Dec;72(6):465–472. [PubMed] [Google Scholar]
  17. Bianchi C., Brollo A., Ramani L., Zuch C. Asbestos-related mesothelioma in Monfalcone, Italy. Am J Ind Med. 1993 Aug;24(2):149–160. doi: 10.1002/ajim.4700240203. [DOI] [PubMed] [Google Scholar]
  18. Bimbi G., Battista G., Belli S., Berrino F., Comba P. Studio caso controllo sui tumori nasali e le esposizioni professionali. Med Lav. 1988 Jul-Aug;79(4):280–287. [PubMed] [Google Scholar]
  19. Bisanti L., Maggini M., Raschetti R., Alegiani S. S., Ippolito F. M., Caffari B., Segnan N., Ponti A. Cancer mortality in ethylene oxide workers. Br J Ind Med. 1993 Apr;50(4):317–324. doi: 10.1136/oem.50.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Blasetti F., Bruno C., Comba P., Fantini F., Grignoli M. Studio di mortalità relativo agli addetti alla costruzione di carrozze ferroviarie a Colleferro. Med Lav. 1990 Sep-Oct;81(5):407–413. [PubMed] [Google Scholar]
  21. Bonassi S., Ceppi M., Puntoni R., Valerio F., Vercelli M., Belli S., Biocca M., Comba P., Ticchiarelli L., Mariotti F. Mortality studies of dockyard workers (longshoremen) in Italy. Am J Ind Med. 1985;7(3):219–227. doi: 10.1002/ajim.4700070304. [DOI] [PubMed] [Google Scholar]
  22. Bonassi S., Merlo F., Pearce N., Puntoni R. Bladder cancer and occupational exposure to polycyclic aromatic hydrocarbons. Int J Cancer. 1989 Oct 15;44(4):648–651. doi: 10.1002/ijc.2910440415. [DOI] [PubMed] [Google Scholar]
  23. Borgia P., Forastiere F., Rapiti E., Rizzelli R., Magliola M. E., Perucci C. A., Axelson O. Mortality among taxi drivers in Rome: a cohort study. Am J Ind Med. 1994 Apr;25(4):507–517. doi: 10.1002/ajim.4700250405. [DOI] [PubMed] [Google Scholar]
  24. Botta M., Magnani C., Terracini B., Bertolone G. P., Castagneto B., Cocito V., DeGiovanni D., Paglieri P. Mortality from respiratory and digestive cancers among asbestos cement workers in Italy. Cancer Detect Prev. 1991;15(6):445–447. [PubMed] [Google Scholar]
  25. Bovenzi M., Stanta G., Antiga G. L., Peruzzo P., Cavallieri F. Occupazione e rischio di tumore polmonare nella provincia di Trieste: uno studio caso-controllo. Med Lav. 1992 Jul-Aug;83(4):338–348. [PubMed] [Google Scholar]
  26. Bovenzi M., Stanta G., Antiga G., Peruzzo P., Cavallieri F. Occupational exposure and lung cancer risk in a coastal area of northeastern Italy. Int Arch Occup Environ Health. 1993;65(1):35–41. doi: 10.1007/BF00586056. [DOI] [PubMed] [Google Scholar]
  27. Bruno C., De Santis M., Comba P., Bagnato R. La mortalità per tumore maligno del peritoneo in Italia: ricerca di correlazioni con l'esposizione ad amianto. Epidemiol Prev. 1990 Dec;12(45):39–47. [PubMed] [Google Scholar]
  28. Buiatti E., Kriebel D., Geddes M., Santucci M., Pucci N. A case control study of lung cancer in Florence, Italy. I. Occupational risk factors. J Epidemiol Community Health. 1985 Sep;39(3):244–250. doi: 10.1136/jech.39.3.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Cammarano G., Crosignani P., Berrino F., Berra G. Cancer mortality among workers in a thermoelectric power plant. Scand J Work Environ Health. 1984 Aug;10(4):259–261. doi: 10.5271/sjweh.2333. [DOI] [PubMed] [Google Scholar]
  30. Carta P., Cocco P. L., Casula D. Mortality from lung cancer among Sardinian patients with silicosis. Br J Ind Med. 1991 Feb;48(2):122–129. doi: 10.1136/oem.48.2.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Carta P., Cocco P., Picchiri G. Lung cancer mortality and airways obstruction among metal miners exposed to silica and low levels of radon daughters. Am J Ind Med. 1994 Apr;25(4):489–506. doi: 10.1002/ajim.4700250404. [DOI] [PubMed] [Google Scholar]
  32. Cecchi F., Buiatti E., Kriebel D., Nastasi L., Santucci M. Adenocarcinoma of the nose and paranasal sinuses in shoemakers and woodworkers in the province of Florence, Italy (1963-77). Br J Ind Med. 1980 Aug;37(3):222–225. doi: 10.1136/oem.37.3.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Ciccone G., Mirabelli D., Levis A., Gavarotti P., Rege-Cambrin G., Davico L., Vineis P. Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control study. Cancer Genet Cytogenet. 1993 Jul 15;68(2):135–139. doi: 10.1016/0165-4608(93)90010-j. [DOI] [PubMed] [Google Scholar]
  34. Ciccone G., Ronco G., Mirabelli D., Coda O., Troia B., D'Incalci F., Gianasso S., Settimi L., Vineis P. Tumori polmonari ed esposizioni professionali in un'area industriale del nord Italia. Med Lav. 1988 Jan-Feb;79(1):54–64. [PubMed] [Google Scholar]
  35. Cocco P. L., Carta P., Belli S., Picchiri G. F., Flore M. V. Mortality of Sardinian lead and zinc miners: 1960-88. Occup Environ Med. 1994 Oct;51(10):674–682. doi: 10.1136/oem.51.10.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Cocco P. L., Carta P., Flore V., Picchiri G. F., Zucca C. Lung cancer mortality among female mine workers exposed to silica. J Occup Med. 1994 Aug;36(8):894–898. [PubMed] [Google Scholar]
  37. Cocco P., Cherchi R., Cherchi P., Onnis R., Daga G., Pisano M. Problems of inference from hypothesis-generating studies on lung cancer and occupation based on routine hospital records. Med Lav. 1993 Sep-Oct;84(5):355–361. [PubMed] [Google Scholar]
  38. Cocco P., Palli D., Buiatti E., Cipriani F., DeCarli A., Manca P., Ward M. H., Blot W. J., Fraumeni J. F., Jr Occupational exposures as risk factors for gastric cancer in Italy. Cancer Causes Control. 1994 May;5(3):241–248. doi: 10.1007/BF01830243. [DOI] [PubMed] [Google Scholar]
  39. Comba P., Barbieri P. G., Battista G., Belli S., Ponterio F., Zanetti D., Axelson O. Cancer of the nose and paranasal sinuses in the metal industry: a case-control study. Br J Ind Med. 1992 Mar;49(3):193–196. doi: 10.1136/oem.49.3.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Comba P., Battista G., Belli S., de Capua B., Merler E., Orsi D., Rodella S., Vindigni C., Axelson O. A case-control study of cancer of the nose and paranasal sinuses and occupational exposures. Am J Ind Med. 1992;22(4):511–520. doi: 10.1002/ajim.4700220406. [DOI] [PubMed] [Google Scholar]
  41. Cordioli G., Cuoghi L., Solari P. L., Berrino F., Crosignani P., Riboli E. Mortalità per tumore in una coorte di lavoratori della industria del vetro. Epidemiol Prev. 1987 Mar;9(30):16–18. [PubMed] [Google Scholar]
  42. Corrao G., Calleri M., Carle F., Russo R., Bosia S., Piccioni P. Cancer risk in a cohort of licensed pesticide users. Scand J Work Environ Health. 1989 Jun;15(3):203–209. doi: 10.5271/sjweh.1861. [DOI] [PubMed] [Google Scholar]
  43. Costa G., Merletti F., Segnan N. A mortality cohort study in a north Italian aircraft factory. Br J Ind Med. 1989 Oct;46(10):738–743. doi: 10.1136/oem.46.10.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Costantini A. S., Paci E., Miligi L., Buiatti E., Martelli C., Lenzi S. Cancer mortality among workers in the Tuscan tanning industry. Br J Ind Med. 1989 Jun;46(6):384–388. doi: 10.1136/oem.46.6.384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Costantini A. S., Pirastu R., Lagorio S., Miligi L., Costa G. Studying cancer among female workers: methods and preliminary results from a record-linkage system in Italy. J Occup Med. 1994 Nov;36(11):1180–1186. doi: 10.1097/00043764-199411000-00003. [DOI] [PubMed] [Google Scholar]
  46. Dardanoni L., Gafà L., Paternò R., Pavone G. A case-control study on lip cancer risk factors in Ragusa (Sicily). Int J Cancer. 1984 Sep 15;34(3):335–337. doi: 10.1002/ijc.2910340309. [DOI] [PubMed] [Google Scholar]
  47. Decarli A., Peto J., Piolatto G., La Vecchia C. Bladder cancer mortality of workers exposed to aromatic amines: analysis of models of carcinogenesis. Br J Cancer. 1985 May;51(5):707–712. doi: 10.1038/bjc.1985.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Di Paola M., Mastrantonio M., Comba P., Grignoli M., Maiozzi P., Martuzzi M. Distribuzione territoriale della mortalità per tumore maligno della pleura in Italia. Ann Ist Super Sanita. 1992;28(4):589–600. [PubMed] [Google Scholar]
  49. Donna A., Crosignani P., Robutti F., Betta P. G., Bocca R., Mariani N., Ferrario F., Fissi R., Berrino F. Triazine herbicides and ovarian epithelial neoplasms. Scand J Work Environ Health. 1989 Feb;15(1):47–53. doi: 10.5271/sjweh.1882. [DOI] [PubMed] [Google Scholar]
  50. Figà-Talamanca I., Mearelli I., Valente P., Bascherini S. Cancer mortality in a cohort of rural licensed pesticide users in the province of Rome. Int J Epidemiol. 1993 Aug;22(4):579–583. doi: 10.1093/ije/22.4.579. [DOI] [PubMed] [Google Scholar]
  51. Figà-Talamanca I., Mearelli I., Valente P. Mortality in a cohort of pesticide applicators in an urban setting. Int J Epidemiol. 1993 Aug;22(4):674–676. doi: 10.1093/ije/22.4.674. [DOI] [PubMed] [Google Scholar]
  52. Forastiere F., Lagorio S., Michelozzi P., Cavariani F., Arca' M., Borgia P., Perucci C., Axelson O. Silica, silicosis and lung cancer among ceramic workers: a case-referent study. Am J Ind Med. 1986;10(4):363–370. doi: 10.1002/ajim.4700100404. [DOI] [PubMed] [Google Scholar]
  53. Forastiere F., Lagorio S., Michelozzi P., Perucci C. A., Axelson O. Mortality pattern of silicotic subjects in the Latium region, Italy. Br J Ind Med. 1989 Dec;46(12):877–880. doi: 10.1136/oem.46.12.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Forastiere F., Perucci C. A., Di Pietro A., Miceli M., Rapiti E., Bargagli A., Borgia P. Mortality among urban policemen in Rome. Am J Ind Med. 1994 Dec;26(6):785–798. doi: 10.1002/ajim.4700260607. [DOI] [PubMed] [Google Scholar]
  55. Forastiere F., Quercia A., Miceli M., Settimi L., Terenzoni B., Rapiti E., Faustini A., Borgia P., Cavariani F., Perucci C. A. Cancer among farmers in central Italy. Scand J Work Environ Health. 1993 Dec;19(6):382–389. doi: 10.5271/sjweh.1458. [DOI] [PubMed] [Google Scholar]
  56. Forastiere F., Valesini S., Salimei E., Magliola M. E., Perucci C. A. Respiratory cancer among soap production workers. Scand J Work Environ Health. 1987 Jun;13(3):258–260. doi: 10.5271/sjweh.2053. [DOI] [PubMed] [Google Scholar]
  57. Franceschi S., Barbone F., Bidoli E., Guarneri S., Serraino D., Talamini R., La Vecchia C. Cancer risk in farmers: results from a multi-site case-control study in north-eastern Italy. Int J Cancer. 1993 Mar 12;53(5):740–745. doi: 10.1002/ijc.2910530506. [DOI] [PubMed] [Google Scholar]
  58. Franchini I., Magnani F., Mutti A. Mortality experience among chromeplating workers. Initial findings. Scand J Work Environ Health. 1983 Jun;9(3):247–252. doi: 10.5271/sjweh.2413. [DOI] [PubMed] [Google Scholar]
  59. Franco F., Chellini E., Seniori Costantini A., Gioia A., Carra G., Paolinelli F., Martelli C., Vigotti M. Mortality in the coke oven plant of Carrara, Italy. Med Lav. 1993 Nov-Dec;84(6):443–447. [PubMed] [Google Scholar]
  60. Gennaro V., Ceppi M., Boffetta P., Fontana V., Perrotta A. Pleural mesothelioma and asbestos exposure among Italian oil refinery workers. Scand J Work Environ Health. 1994 Jun;20(3):213–215. doi: 10.5271/sjweh.1406. [DOI] [PubMed] [Google Scholar]
  61. Giarelli L., Bianchi C., Grandi G. Malignant mesothelioma of the pleura in Trieste, Italy. Am J Ind Med. 1992;22(4):521–530. doi: 10.1002/ajim.4700220407. [DOI] [PubMed] [Google Scholar]
  62. Giaroli C., Belli S., Bruno C., Candela S., Grignoli M., Minisci S., Poletti R., Riccò G., Vecchi G., Venturi G. Mortality study of asbestos cement workers. Int Arch Occup Environ Health. 1994;66(1):7–11. doi: 10.1007/BF00386573. [DOI] [PubMed] [Google Scholar]
  63. Giovanazzi A., D'Andrea F. Cause di morte fra i lavoratori di un impianto di riduzione elettrolitica di allumina. Med Lav. 1981 Jul-Aug;72(4):277–282. [PubMed] [Google Scholar]
  64. Kogevinas M., Ferro G., Andersen A., Bellander T., Biocca M., Coggon D., Gennaro V., Hutchings S., Kolstad H., Lundberg I. Cancer mortality in a historical cohort study of workers exposed to styrene. Scand J Work Environ Health. 1994 Aug;20(4):251–261. doi: 10.5271/sjweh.1400. [DOI] [PubMed] [Google Scholar]
  65. Lagorio S., Forastiere F., Rapiti E., Di Pietro A., Costa G. Attività economiche e professioni ad elevato rischio di mortalità per tumore polmonare a Torino (1981-89) e in Italia (1981-82). Med Lav. 1995 Jul-Aug;86(4):309–324. [PubMed] [Google Scholar]
  66. Magnani C., Comba P., Ferraris F., Ivaldi C., Meneghin M., Terracini B. A case-control study of carcinomas of the nose and paranasal sinuses in the woolen textile manufacturing industry. Arch Environ Health. 1993 Mar-Apr;48(2):94–97. doi: 10.1080/00039896.1993.9938401. [DOI] [PubMed] [Google Scholar]
  67. Magnani C., Nardini I., Governa M., Serio A. Uno studio di coorte degli addetti ad una officina di grandi riparazioni (O.G.R.) delle ferrovie dello stato. Med Lav. 1986 Mar-Apr;77(2):154–161. [PubMed] [Google Scholar]
  68. Magnani C., Nardini I., Governa M., Serio A. Uno studio di coorte degli addetti ad una officina di grandi riparazioni (O.G.R.) delle ferrovie dello stato. Med Lav. 1986 Mar-Apr;77(2):154–161. [PubMed] [Google Scholar]
  69. Magnani C., Terracini B., Bertolone G. P., Castagneto B., Cocito V., De Giovanni D., Paglieri P., Botta M. Mortalità per tumori e altre malattie del sistema respiratorio tra i lavoratori del cemento-amianto a Casale Monferrato. Uno studio di coorte storico. Med Lav. 1987 Nov-Dec;78(6):441–453. [PubMed] [Google Scholar]
  70. Magnani C., Terracini B., Ivaldi C., Mancini A., Botta M. Mortalità per tumori e altre cause tra i lavoratori del cemento-amianto a Casale Monferrato. Med Lav. 1996 Mar-Apr;87(2):133–146. [PubMed] [Google Scholar]
  71. Magnani C., Terracini B., Ivaldi C., Mancini A., Botta M. Mortalità per tumori e altre cause tra i lavoratori del cemento-amianto a Casale Monferrato. Med Lav. 1996 Mar-Apr;87(2):133–146. [PubMed] [Google Scholar]
  72. Mastrangelo G., Zambon P., Simonato L., Rizzi P. A case-referent study investigating the relationship between exposure to silica dust and lung cancer. Int Arch Occup Environ Health. 1988;60(4):299–302. doi: 10.1007/BF00378477. [DOI] [PubMed] [Google Scholar]
  73. Menegozzo M., Belli S., Bruno C., Canfora V., Costigliola A., Di Cintio P., Di Liello L., Grignoli M., Palumbo F., Sapio P. La mortalità per cause correlabili all'amianto in una coorte di addetti alla costruzione di carrozze ferroviarie. Med Lav. 1993 May-Jun;84(3):193–200. [PubMed] [Google Scholar]
  74. Merler E., Alhaique D., Bracci C. L'aggiornamento della Tabella Italiana delle Malattie Professionali Indennizzabili. Epidemiol Prev. 1994 Sep;18(60):180–183. [PubMed] [Google Scholar]
  75. Merler E., Baldasseroni A., Laria R., Faravelli P., Agostini R., Pisa R., Berrino F. On the causal association between exposure to leather dust and nasal cancer: further evidence from a case-control study. Br J Ind Med. 1986 Feb;43(2):91–95. doi: 10.1136/oem.43.2.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Merler E., Boffetta P., Masala G., Monechi V., Bani F. A cohort study of workers compensated for mercury intoxication following employment in the fur hat industry. J Occup Med. 1994 Nov;36(11):1260–1264. doi: 10.1097/00043764-199411000-00016. [DOI] [PubMed] [Google Scholar]
  77. Merler E., Brizzi S. Compensation of occupational diseases and particularly of asbestos-related diseases among the European Community (EEC) countries. Epidemiol Prev. 1994 Sep;18(60):170–179. [PubMed] [Google Scholar]
  78. Merletti F., Boffetta P., Ferro G., Pisani P., Terracini B. Occupation and cancer of the oral cavity or oropharynx in Turin, Italy. Scand J Work Environ Health. 1991 Aug;17(4):248–254. doi: 10.5271/sjweh.1706. [DOI] [PubMed] [Google Scholar]
  79. Merlo F., Costantini M., Reggiardo G., Ceppi M., Puntoni R. Lung cancer risk among refractory brick workers exposed to crystalline silica: a retrospective cohort study. Epidemiology. 1991 Jul;2(4):299–305. doi: 10.1097/00001648-199107000-00012. [DOI] [PubMed] [Google Scholar]
  80. Merlo F., Fontana L., Reggiardo G., Ceppi M., Barisione G., Garrone E., Doria M. Mortality among silicotics in Genoa, Italy, from 1961 to 1987. Scand J Work Environ Health. 1995;21 (Suppl 2):77–80. [PubMed] [Google Scholar]
  81. Musicco M., Filippini G., Bordo B. M., Melotto A., Morello G., Berrino F. Gliomas and occupational exposure to carcinogens: case-control study. Am J Epidemiol. 1982 Nov;116(5):782–790. doi: 10.1093/oxfordjournals.aje.a113468. [DOI] [PubMed] [Google Scholar]
  82. Musicco M., Sant M., Molinari S., Filippini G., Gatta G., Berrino F. A case-control study of brain gliomas and occupational exposure to chemical carcinogens: the risk to farmers. Am J Epidemiol. 1988 Oct;128(4):778–785. doi: 10.1093/oxfordjournals.aje.a115031. [DOI] [PubMed] [Google Scholar]
  83. Negri E., Piolatto G., Pira E., Decarli A., Kaldor J., La Vecchia C. Cancer mortality in a northern Italian cohort of rubber workers. Br J Ind Med. 1989 Sep;46(9):624–628. doi: 10.1136/oem.46.9.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Paci E., Buiatti E., Geddes M. A case-referent study of lung tumors in non-asbestos textile workers. Am J Ind Med. 1987;11(3):267–273. doi: 10.1002/ajim.4700110304. [DOI] [PubMed] [Google Scholar]
  85. Paci E., Buiatti E., Seniori Costantini A. S., Miligi L., Pucci N., Scarpelli A., Petrioli G., Simonato L., Winkelmann R., Kaldor J. M. Aplastic anemia, leukemia and other cancer mortality in a cohort of shoe workers exposed to benzene. Scand J Work Environ Health. 1989 Oct;15(5):313–318. doi: 10.5271/sjweh.1845. [DOI] [PubMed] [Google Scholar]
  86. Paci E., Buiatti E., Zappa M., Di Natale M., Vannucchi G., Dini S., Biancalani M. Inquinamento da asbesto nel ciclo tessile pratese: l'evidenza epidemiologica. Med Lav. 1987 Jul-Aug;78(4):283–292. [PubMed] [Google Scholar]
  87. Paci E., Dini S., Buiatti E., Seniori Costantini A., Lenzi S., Zappa M. Malignant mesothelioma in non-asbestos textile workers in Florence. Am J Ind Med. 1987;11(3):249–254. doi: 10.1002/ajim.4700110302. [DOI] [PubMed] [Google Scholar]
  88. Paci E., Zappa M., Paoletti L., Buiatti E., Chellini E., Merler E., Seniori Costantini A. Further evidence of an excess of risk of pleural malignant mesothelioma in textile workers in Prato (Italy). Br J Cancer. 1991 Aug;64(2):377–378. doi: 10.1038/bjc.1991.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Parolari G., Merler E., Ricci P. Mortalità per tumore attribuibile all'esposizione lavorativa ad amianto-amosite in una communità. Epidemiol Prev. 1988 Dec;10(37):32–37. [PubMed] [Google Scholar]
  90. Pasqualetti P., Casale R., Colantonio D., Collacciani A. Occupational risk for hematological malignancies. Am J Hematol. 1991 Oct;38(2):147–149. doi: 10.1002/ajh.2830380216. [DOI] [PubMed] [Google Scholar]
  91. Pasqualetti P., Casale R., Collacciani A., Colantonio D. Attività lavorativa e rischio di mieloma multiplo. Uno studio caso-controllo. Med Lav. 1990 Jul-Aug;81(4):308–319. [PubMed] [Google Scholar]
  92. Pastorino U., Berrino F., Gervasio A., Pesenti V., Riboli E., Crosignani P. Proportion of lung cancers due to occupational exposure. Int J Cancer. 1984 Feb 15;33(2):231–237. doi: 10.1002/ijc.2910330211. [DOI] [PubMed] [Google Scholar]
  93. Petrelli G., Menniti Ippolito F., Spila Alegiani S., Magarotto G., Taroni F. Mortality among workers of three thermoelectric power plants in northern Italy: a retrospective cohort study. Med Lav. 1994 Sep-Oct;85(5):397–401. [PubMed] [Google Scholar]
  94. Petrelli G., Menniti-Ippolito F., Taroni F., Raschetti R., Magarotto G. A retrospective cohort mortality study on workers of two thermoelectric power plants: fourteen-year follow-up results. Eur J Epidemiol. 1989 Mar;5(1):87–89. doi: 10.1007/BF00145051. [DOI] [PubMed] [Google Scholar]
  95. Pettinari A., Mengucci R., Belli S., Comba P. Studio di mortalità degli addetti alla produzione di manufatti in cemento-amianto nello stabilimento di Senigallia. Med Lav. 1994 May-Jun;85(3):223–230. [PubMed] [Google Scholar]
  96. Piolatto G., Negri E., La Vecchia C., Pira E., Decarli A., Peto J. An update of cancer mortality among chrysotile asbestos miners in Balangero, northern Italy. Br J Ind Med. 1990 Dec;47(12):810–814. doi: 10.1136/oem.47.12.810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Piolatto G., Negri E., La Vecchia C., Pira E., Decarli A., Peto J. Bladder cancer mortality of workers exposed to aromatic amines: an updated analysis. Br J Cancer. 1991 Mar;63(3):457–459. doi: 10.1038/bjc.1991.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Pirastu R., Belli S., Bruno C., Comba P., De Santis M., Foà V., Maltoni C., Masina A., Reggiani A. La mortalità dei produttori di cloruro di vinile in Italia. Med Lav. 1991 Sep-Oct;82(5):388–423. [PubMed] [Google Scholar]
  99. Pirastu R., Comba P., Reggiani A., Foa V., Masina A., Maltoni C. Mortality from liver disease among Italian vinyl chloride monomer/polyvinyl chloride manufacturers. Am J Ind Med. 1990;17(2):155–161. doi: 10.1002/ajim.4700170202. [DOI] [PubMed] [Google Scholar]
  100. Puntoni R., Bolognesi C., Bonassi S., Merlo F., Mari A., Merialdo G., Santi L. Cancer risk evaluation in an area with a high density of chemical plants. An interdisciplinary approach. Ann N Y Acad Sci. 1988;534:808–816. doi: 10.1111/j.1749-6632.1988.tb30168.x. [DOI] [PubMed] [Google Scholar]
  101. Puntoni R., Goldsmith D. F., Valerio F., Vercelli M., Bonassi S., Di Giorgio F., Ceppi M., Stagnaro E., Filiberti R., Santi L. A cohort study of workers employed in a refractory brick plant. Tumori. 1988 Feb 29;74(1):27–33. doi: 10.1177/030089168807400105. [DOI] [PubMed] [Google Scholar]
  102. Puntoni R., Valerio A., Cresta E., Filiberti R., Bonassi S., Vercelli M. Studio di mortalità fra i lavoratori di una conceria. Med Lav. 1984 Nov-Dec;75(6):471–477. [PubMed] [Google Scholar]
  103. Puntoni R., Vercelli M., Merlo F., Valerio F., Santi L. Mortality among shipyard workers in Genoa, Italy. Ann N Y Acad Sci. 1979;330:353–377. doi: 10.1111/j.1749-6632.1979.tb18738.x. [DOI] [PubMed] [Google Scholar]
  104. Rapiti E., Turi E., Forastiere F., Borgia P., Comba P., Perucci C. A., Axelson O. A mortality cohort study of seamen in Italy. Am J Ind Med. 1992;21(6):863–872. doi: 10.1002/ajim.4700210609. [DOI] [PubMed] [Google Scholar]
  105. Riboli E., Bai E., Berrino F., Merisi A. Mortality from lung cancer in an acetylene and phthalic anhydride plant. A case-referent study. Scand J Work Environ Health. 1983 Dec;9(6):455–462. doi: 10.5271/sjweh.2387. [DOI] [PubMed] [Google Scholar]
  106. Ronco G., Ciccone G., Mirabelli D., Troia B., Vineis P. Occupation and lung cancer in two industrialized areas of northern Italy. Int J Cancer. 1988 Mar 15;41(3):354–358. doi: 10.1002/ijc.2910410306. [DOI] [PubMed] [Google Scholar]
  107. Ronco G., Costa G., Lynge E. Cancer risk among Danish and Italian farmers. Br J Ind Med. 1992 Apr;49(4):220–225. doi: 10.1136/oem.49.4.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Rubino G. F., Piolatto G., Newhouse M. L., Scansetti G., Aresini G. A., Murray R. Mortality of chrysotile asbestos workers at the Balangero Mine, Northern Italy. Br J Ind Med. 1979 Aug;36(3):187–194. doi: 10.1136/oem.36.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Rubino G. F., Scansetti G., Piolatto G., Pira E. The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man. Environ Res. 1982 Apr;27(2):241–254. doi: 10.1016/0013-9351(82)90079-2. [DOI] [PubMed] [Google Scholar]
  110. Rubino G. F., Scansetti G., Piolatto G., Romano C. A. Mortality study of talc miners and millers. J Occup Med. 1976 Mar;18(3):187–193. [PubMed] [Google Scholar]
  111. Tarchi M., Orsi D., Comba P., De Santis M., Pirastu R., Battista G., Valiani M. Cohort mortality study of rock salt workers in Italy. Am J Ind Med. 1994 Feb;25(2):251–256. doi: 10.1002/ajim.4700250211. [DOI] [PubMed] [Google Scholar]
  112. Tironi A., Pesatori A., Consonni D., Zocchetti C., Bertazzi P. A. Mortalità di lavoratrici esposte a APCB. Epidemiol Prev. 1996 Apr-Sep;20(2-3):200–202. [PubMed] [Google Scholar]
  113. Torchio P., Lepore A. R., Corrao G., Comba P., Settimi L., Belli S., Magnani C., di Orio F. Mortality study on a cohort of Italian licensed pesticide users. Sci Total Environ. 1994 Jun 20;149(3):183–191. doi: 10.1016/0048-9697(94)90178-3. [DOI] [PubMed] [Google Scholar]
  114. Vai T., Radice L., Catenacci G., Biscaldi G. P., Guercilena S., Pesatori A. C., Bertazzi P. A. Studio a distanza di 304 casi di sospetta patologia da benzene osservati negli anni 1950-1971. Med Lav. 1989 Sep-Oct;80(5):397–404. [PubMed] [Google Scholar]
  115. Vineis P., Magnani C. Occupation and bladder cancer in males: a case-control study. Int J Cancer. 1985 May 15;35(5):599–606. doi: 10.1002/ijc.2910350506. [DOI] [PubMed] [Google Scholar]
  116. Vineis P., Seniori Costantini A. Italian multicentre case-control study of hematolymphopoietic malignancies. Med Lav. 1990 Nov-Dec;81(6):506–512. [PubMed] [Google Scholar]
  117. Vineis P., Terracini B., Ciccone G., Cignetti A., Colombo E., Donna A., Maffi L., Pisa R., Ricci P., Zanini E. Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. A population-based case-referent study. Scand J Work Environ Health. 1987 Feb;13(1):9–17. doi: 10.5271/sjweh.2077. [DOI] [PubMed] [Google Scholar]
  118. Vineis P., Thomas T., Hayes R. B., Blot W. J., Mason T. J., Pickle L. W., Correa P., Fontham E. T., Schoenberg J. Proportion of lung cancers in males, due to occupation, in different areas of the USA. Int J Cancer. 1988 Dec 15;42(6):851–856. doi: 10.1002/ijc.2910420610. [DOI] [PubMed] [Google Scholar]
  119. Zambon P., Corsi G., Bertin T., Camporese R., Simonato L. Studio epidemiologico di mortalità in una coorte di addetti alla produzione del rayon viscosa. Med Lav. 1994 Sep-Oct;85(5):390–396. [PubMed] [Google Scholar]
  120. Zambon P., Simonato L., Mastrangelo G., Winkelmann R., Saia B., Crepet M. Mortality of workers compensated for silicosis during the period 1959-1963 in the Veneto region of Italy. Scand J Work Environ Health. 1987 Apr;13(2):118–123. doi: 10.5271/sjweh.2072. [DOI] [PubMed] [Google Scholar]
  121. Zappa M., Paci E., Seniori Costantini A., Kriebel D. Lung cancer among textile workers in the Prato area of Italy. Scand J Work Environ Health. 1993 Feb;19(1):16–20. doi: 10.5271/sjweh.1509. [DOI] [PubMed] [Google Scholar]
  122. de Marco R., Bernardinelli L., Mangione M. P. Rischio di morte per tumore dell'apparato respiratorio in lavoratori addetti alla produzione di cromati. Med Lav. 1988 Sep-Oct;79(5):368–376. [PubMed] [Google Scholar]
  123. la Vecchia C., Negri E., D'Avanzo B., Franceschi S. Occupation and the risk of bladder cancer. Int J Epidemiol. 1990 Jun;19(2):264–268. doi: 10.1093/ije/19.2.264. [DOI] [PubMed] [Google Scholar]

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