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. 1999 Feb;107(Suppl 1):181–190. doi: 10.1289/ehp.99107s1181

Geographic exposure modeling: a valuable extension of geographic information systems for use in environmental epidemiology.

J Beyea 1
PMCID: PMC1566356  PMID: 10229717

Abstract

Geographic modeling of individual exposures using air pollution modeling techniques can help in both the design of environmental epidemiologic studies and in the assignment of measures that delineate regions that receive the highest exposure in space and time. Geographic modeling can help in the interpretation of environmental sampling data associated with airborne concentration or deposition, and can act as a sophisticated interpolator for such data, allowing values to be assigned to locations between points where the data have actually been collected. Recent advances allow for quantification of the uncertainty in a geographic model and the resulting impact on estimates of association, variability, and study power. In this paper we present the terminology and methodology of geographic modeling, describe applications to date in the field of epidemiology, and evaluate the potential of this relatively new tool.

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Selected References

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  1. Armstrong B. G., Oakes D. Effects of approximation in exposure assessments on estimates of exposure- response relationships. Scand J Work Environ Health. 1982;8 (Suppl 1):20–23. [PubMed] [Google Scholar]
  2. Armstrong T. W., Pearlman E. D., Schnatter A. R., Bowes S. M., 3rd, Murray N., Nicolich M. J. Retrospective benzene and total hydrocarbon exposure assessment for a petroleum marketing and distribution worker epidemiology study. Am Ind Hyg Assoc J. 1996 Apr;57(4):333–343. doi: 10.1080/15428119691014864. [DOI] [PubMed] [Google Scholar]
  3. Brown L. M., Pottern L. M., Blot W. J. Lung cancer in relation to environmental pollutants emitted from industrial sources. Environ Res. 1984 Aug;34(2):250–261. doi: 10.1016/0013-9351(84)90093-8. [DOI] [PubMed] [Google Scholar]
  4. Buglova E. E., Kenigsberg J. E., Sergeeva N. V. Cancer risk estimation in Belarussian children due to thyroid irradiation as a consequence of the Chernobyl nuclear accident. Health Phys. 1996 Jul;71(1):45–49. doi: 10.1097/00004032-199607000-00007. [DOI] [PubMed] [Google Scholar]
  5. Chiazze L., Jr, Watkins D. K., Fryar C., Kozono J. A case-control study of malignant and non-malignant respiratory disease among employees of a fiberglass manufacturing facility. II. Exposure assessment. Br J Ind Med. 1993 Aug;50(8):717–725. doi: 10.1136/oem.50.8.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Delfino R. J., Becklake M. R., Hanley J. A., Singh B. Estimation of unmeasured particulate air pollution data for an epidemiological study of daily respiratory morbidity. Environ Res. 1994 Oct;67(1):20–38. doi: 10.1006/enrs.1994.1062. [DOI] [PubMed] [Google Scholar]
  7. Dosemeci M., McLaughlin J. K., Chen J. Q., Hearl F., McCawley M., Wu Z., Chen R. G., Peng K. L., Chen A. L., Rexing S. H. Indirect validation of a retrospective method of exposure assessment used in a nested case-control study of lung cancer and silica exposure. Occup Environ Med. 1994 Feb;51(2):136–138. doi: 10.1136/oem.51.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dosemeci M., Yin S. N., Linet M., Wacholder S., Rothman N., Li G. L., Chow W. H., Wang Y. Z., Jiang Z. L., Dai T. R. Indirect validation of benzene exposure assessment by association with benzene poisoning. Environ Health Perspect. 1996 Dec;104 (Suppl 6):1343–1347. doi: 10.1289/ehp.961041343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Elliott P., Hills M., Beresford J., Kleinschmidt I., Jolley D., Pattenden S., Rodrigues L., Westlake A., Rose G. Incidence of cancers of the larynx and lung near incinerators of waste solvents and oils in Great Britain. Lancet. 1992 Apr 4;339(8797):854–858. doi: 10.1016/0140-6736(92)90290-j. [DOI] [PubMed] [Google Scholar]
  10. Esmen N. A., Marsh G. M. Applications and limitations of air dispersion modeling in environmental epidemiology. J Expo Anal Environ Epidemiol. 1996 Jul-Sep;6(3):339–353. [PubMed] [Google Scholar]
  11. Funk L. M., Sedman R., Beals J. A., Fountain R. Quantifying the distribution of inhalation exposure in human populations: 2. Distributions of time spent by adults, adolescents, and children at home, at work, and at school. Risk Anal. 1998 Feb;18(1):47–56. doi: 10.1111/j.1539-6924.1998.tb00915.x. [DOI] [PubMed] [Google Scholar]
  12. Gallagher M. D., Nuckols J. R., Stallones L., Savitz D. A. Exposure to trihalomethanes and adverse pregnancy outcomes. Epidemiology. 1998 Sep;9(5):484–489. [PubMed] [Google Scholar]
  13. Guo S. W., Thompson E. A. Monte Carlo estimation of mixed models for large complex pedigrees. Biometrics. 1994 Jun;50(2):417–432. [PubMed] [Google Scholar]
  14. Guthe W. G., Tucker R. K., Murphy E. A., England R., Stevenson E., Luckhardt J. C. Reassessment of lead exposure in New Jersey using GIS technology. Environ Res. 1992 Dec;59(2):318–325. doi: 10.1016/s0013-9351(05)80038-6. [DOI] [PubMed] [Google Scholar]
  15. Hatch M. C., Beyea J., Nieves J. W., Susser M. Cancer near the Three Mile Island nuclear plant: radiation emissions. Am J Epidemiol. 1990 Sep;132(3):397–417. doi: 10.1093/oxfordjournals.aje.a115673. [DOI] [PubMed] [Google Scholar]
  16. Heeb C. M., Gydesen S. P., Simpson J. C., Bates D. J. Reconstruction of radionuclide releases from the Hanford Site, 1944-1972. Health Phys. 1996 Oct;71(4):545–555. doi: 10.1097/00004032-199610000-00012. [DOI] [PubMed] [Google Scholar]
  17. Hoffman F. O., Hammonds J. S. Propagation of uncertainty in risk assessments: the need to distinguish between uncertainty due to lack of knowledge and uncertainty due to variability. Risk Anal. 1994 Oct;14(5):707–712. doi: 10.1111/j.1539-6924.1994.tb00281.x. [DOI] [PubMed] [Google Scholar]
  18. Hornung R. W., Greife A. L., Stayner L. T., Steenland N. K., Herrick R. F., Elliott L. J., Ringenburg V. L., Morawetz J. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. Am J Ind Med. 1994 Jun;25(6):825–836. doi: 10.1002/ajim.4700250607. [DOI] [PubMed] [Google Scholar]
  19. Hornung R. W., Herrick R. F., Stewart P. A., Utterback D. F., Feigley C. E., Wall D. K., Douthit D. E., Hayes R. B. An experimental design approach to retrospective exposure assessment. Am Ind Hyg Assoc J. 1996 Mar;57(3):251–256. doi: 10.1080/15428119691014972. [DOI] [PubMed] [Google Scholar]
  20. Ihrig M. M., Shalat S. L., Baynes C. A hospital-based case-control study of stillbirths and environmental exposure to arsenic using an atmospheric dispersion model linked to a geographical information system. Epidemiology. 1998 May;9(3):290–294. [PubMed] [Google Scholar]
  21. Kerber R. A., Till J. E., Simon S. L., Lyon J. L., Thomas D. C., Preston-Martin S., Rallison M. L., Lloyd R. D., Stevens W. A cohort study of thyroid disease in relation to fallout from nuclear weapons testing. JAMA. 1993 Nov 3;270(17):2076–2082. [PubMed] [Google Scholar]
  22. Lewis-Michl E. L., Melius J. M., Kallenbach L. R., Ju C. L., Talbot T. O., Orr M. F., Lauridsen P. E. Breast cancer risk and residence near industry or traffic in Nassau and Suffolk Counties, Long Island, New York. Arch Environ Health. 1996 Jul-Aug;51(4):255–265. doi: 10.1080/00039896.1996.9936024. [DOI] [PubMed] [Google Scholar]
  23. Lloyd R. D., Tripp D. A., Kerber R. A. Limits of fetal thyroid risk from radioiodine exposure. Health Phys. 1996 Apr;70(4):559–562. doi: 10.1097/00004032-199604000-00015. [DOI] [PubMed] [Google Scholar]
  24. Marshall R. J. Assessment of exposure misclassification bias in case-control studies using validation data. J Clin Epidemiol. 1997 Jan;50(1):15–19. doi: 10.1016/s0895-4356(96)00315-0. [DOI] [PubMed] [Google Scholar]
  25. Meyer K. R., Voillequé P. G., Schmidt D. W., Rope S. K., Killough G. G., Shleien B., Moore R. E., Case M. J., Till J. E. Overview of the Fernald Dosimetry Reconstruction Project and source term estimates for 1951-1988. Health Phys. 1996 Oct;71(4):425–437. doi: 10.1097/00004032-199610000-00002. [DOI] [PubMed] [Google Scholar]
  26. Miller C. W., Smith J. M. Why should we do environmental dose reconstructions? Health Phys. 1996 Oct;71(4):420–424. doi: 10.1097/00004032-199610000-00001. [DOI] [PubMed] [Google Scholar]
  27. Mühlemann K., Weiss N. S. Can herd immunity influence the assessment of vaccine efficacy in nonrandomized studies? Am J Public Health. 1997 Jan;87(1):113–114. doi: 10.2105/ajph.87.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Nair S. K., Miller C. W., Thiessen K. M., Garger E. K., Hoffman F. O. Modeling the resuspension of radionuclides in Ukrainian regions impacted by Chernobyl fallout. Health Phys. 1997 Jan;72(1):77–85. doi: 10.1097/00004032-199701000-00010. [DOI] [PubMed] [Google Scholar]
  29. Rai S. N., Krewski D. Uncertainty and variability analysis in multiplicative risk models. Risk Anal. 1998 Feb;18(1):37–45. doi: 10.1111/j.1539-6924.1998.tb00914.x. [DOI] [PubMed] [Google Scholar]
  30. Ripple S. R., Widner T. E., Mongan T. R. Past radionuclide releases from routine operations at Rocky Flats. Health Phys. 1996 Oct;71(4):502–509. doi: 10.1097/00004032-199610000-00008. [DOI] [PubMed] [Google Scholar]
  31. Rosner B., Spiegelman D., Willett W. C. Correction of logistic regression relative risk estimates and confidence intervals for random within-person measurement error. Am J Epidemiol. 1992 Dec 1;136(11):1400–1413. doi: 10.1093/oxfordjournals.aje.a116453. [DOI] [PubMed] [Google Scholar]
  32. Rønneberg A. Mortality and cancer morbidity in workers from an aluminium smelter with prebaked carbon anodes--Part I: Exposure assessment. Occup Environ Med. 1995 Apr;52(4):242–249. doi: 10.1136/oem.52.4.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Schill W., Jöckel K. H. The analysis of case-control studies under validation subsampling. Eur J Clin Nutr. 1993 Oct;47 (Suppl 2):S34–S41. [PubMed] [Google Scholar]
  34. Seifert B. Validity criteria for exposure assessment methods. Sci Total Environ. 1995 Jun 16;168(2):101–107. doi: 10.1016/0048-9697(95)04613-6. [DOI] [PubMed] [Google Scholar]
  35. Shipler D. B., Napier B. A., Farris W. T., Freshley M. D. Hanford Environmental Dose Reconstruction Project--an overview. Health Phys. 1996 Oct;71(4):532–544. doi: 10.1097/00004032-199610000-00011. [DOI] [PubMed] [Google Scholar]
  36. Siemiatycki J., Fritschi L., Nadon L., Gérin M. Reliability of an expert rating procedure for retrospective assessment of occupational exposures in community-based case-control studies. Am J Ind Med. 1997 Mar;31(3):280–286. doi: 10.1002/(sici)1097-0274(199703)31:3<280::aid-ajim3>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  37. Simon S. L., Till J. E., Lloyd R. D., Kerber R. L., Thomas D. C., Preston-Martin S., Lyon J. L., Stevens W. The Utah Leukemia Case-Control Study: dosimetry methodology and results. Health Phys. 1995 Apr;68(4):460–471. doi: 10.1097/00004032-199504000-00003. [DOI] [PubMed] [Google Scholar]
  38. Stevens W., Thomas D. C., Lyon J. L., Till J. E., Kerber R. A., Simon S. L., Lloyd R. D., Elghany N. A., Preston-Martin S. Leukemia in Utah and radioactive fallout from the Nevada test site. A case-control study. JAMA. 1990 Aug 1;264(5):585–591. [PubMed] [Google Scholar]
  39. Taylor A. C. Using objective and subjective information to develop distributions for probabilistic exposure assessment. J Expo Anal Environ Epidemiol. 1993 Jul-Sep;3(3):285–298. [PubMed] [Google Scholar]
  40. Thomas D., Stram D., Dwyer J. Exposure measurement error: influence on exposure-disease. Relationships and methods of correction. Annu Rev Public Health. 1993;14:69–93. doi: 10.1146/annurev.pu.14.050193.000441. [DOI] [PubMed] [Google Scholar]
  41. Thompson C. B., McArthur R. D. Challenges in developing estimates of exposure rate near the Nevada Test Site. Health Phys. 1996 Oct;71(4):470–476. doi: 10.1097/00004032-199610000-00005. [DOI] [PubMed] [Google Scholar]
  42. Till J. E., Simon S. L., Kerber R., Lloyd R. D., Stevens W., Thomas D. C., Lyon J. L., Preston-Martin S. The Utah Thyroid Cohort Study: analysis of the dosimetry results. Health Phys. 1995 Apr;68(4):472–483. doi: 10.1097/00004032-199504000-00004. [DOI] [PubMed] [Google Scholar]
  43. Watt M., Godden D., Cherrie J., Seaton A. Individual exposure to particulate air pollution and its relevance to thresholds for health effects: a study of traffic wardens. Occup Environ Med. 1995 Dec;52(12):790–792. doi: 10.1136/oem.52.12.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Williams M. L. Monitoring of exposure to air pollution. Sci Total Environ. 1995 Jun 16;168(2):169–174. doi: 10.1016/0048-9697(95)04620-g. [DOI] [PubMed] [Google Scholar]
  45. Wing S., Richardson D., Armstrong D., Crawford-Brown D. A reevaluation of cancer incidence near the Three Mile Island nuclear plant: the collision of evidence and assumptions. Environ Health Perspect. 1997 Jan;105(1):52–57. doi: 10.1289/ehp.9710552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Wrensch M., Swan S., Murphy P. J., Lipscomb J., Claxton K., Epstein D., Neutra R. Hydrogeologic assessment of exposure to solvent-contaminated drinking water: pregnancy outcomes in relation to exposure. Arch Environ Health. 1990 Jul-Aug;45(4):210–216. doi: 10.1080/00039896.1990.9940804. [DOI] [PubMed] [Google Scholar]
  47. de Cock J., Kromhout H., Heederik D., Burema J. Experts' subjective assessment of pesticide exposure in fruit growing. Scand J Work Environ Health. 1996 Dec;22(6):425–432. doi: 10.5271/sjweh.163. [DOI] [PubMed] [Google Scholar]

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