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. 1999 Sep;107(9):715–719. doi: 10.1289/ehp.99107715

Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort.

Y L Guo 1, M L Yu 1, C C Hsu 1, W J Rogan 1
PMCID: PMC1566448  PMID: 10464071

Abstract

In 1979, a mass poisoning involving 2,000 people occurred in central Taiwan from ingestion of cooking oil contaminated by polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). We studied the prevalence of medical conditions in the exposed individuals and in a neighborhood control group. Starting with a registry of the exposed individuals from 1983, we updated the addresses of exposed individuals and identified a control group matched for age, sex, and neighborhood in 1979. In 1993, individuals 30 years of age or older were interviewed by telephone. We obtained usable information from 795 exposed subjects and 693 control subjects. Lifetime prevalence of chloracne, abnormal nails, hyperkeratosis, skin allergy, goiter, headache, gum pigmentation, and broken teeth were observed more frequently in the PCB/PCDF-exposed men and women. The exposed women reported anemia 2. 3 times more frequently than controls. The exposed men reported arthritis and herniated intervertebral disks 4.1 and 2.9 times, respectively, more frequently than controls. There was no difference in reported prevalences of other medical conditions. We conclude that Taiwanese people exposed to high levels of PCBs and PCDFs reported more frequent medical problems, including skin diseases, goiter, anemia, and joint and spine diseases.

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Selected References

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  1. Chao W. Y., Hsu C. C., Guo Y. L. Middle-ear disease in children exposed prenatally to polychlorinated biphenyls and polychlorinated dibenzofurans. Arch Environ Health. 1997 Jul-Aug;52(4):257–262. doi: 10.1080/00039899709602195. [DOI] [PubMed] [Google Scholar]
  2. Chen R. C., Tang S. Y., Miyata H., Kashimoto T., Chang Y. C., Chang K. J., Tung T. C. Polychlorinated biphenyl poisoning: correlation of sensory and motor nerve conduction, neurologic symptoms, and blood levels of polychlorinated biphenyls, quaterphenyls, and dibenzofurans. Environ Res. 1985 Aug;37(2):340–348. doi: 10.1016/0013-9351(85)90114-8. [DOI] [PubMed] [Google Scholar]
  3. Clark G. C., Taylor M. J., Tritscher A. M., Lucier G. W. Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Toxicol Appl Pharmacol. 1991 Dec;111(3):422–431. doi: 10.1016/0041-008x(91)90247-c. [DOI] [PubMed] [Google Scholar]
  4. Fan F., Pinson D. M., Rozman K. K. Immunomodulatory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin tested by the popliteal lymph node assay. Toxicol Pathol. 1995 Jul-Aug;23(4):513–517. doi: 10.1177/019262339502300408. [DOI] [PubMed] [Google Scholar]
  5. Guo Y. L., Ryan J. J., Lau B. P., Yu M. L., Hsu C. C. Blood serum levels of PCBs and PCDFs in Yucheng women 14 years after exposure to a toxic rice oil. Arch Environ Contam Toxicol. 1997 Jul;33(1):104–108. doi: 10.1007/s002449900230. [DOI] [PubMed] [Google Scholar]
  6. Henriksen G. L., Ketchum N. S., Michalek J. E., Swaby J. A. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology. 1997 May;8(3):252–258. doi: 10.1097/00001648-199705000-00005. [DOI] [PubMed] [Google Scholar]
  7. Hsu S. T., Ma C. I., Hsu S. K., Wu S. S., Hsu N. H., Yeh C. C., Wu S. B. Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup. Environ Health Perspect. 1985 Feb;59:5–10. doi: 10.1289/ehp.59-1568088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kuratsune M., Yoshimura T., Matsuzaka J., Yamaguchi A. Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls. Environ Health Perspect. 1972 Apr;1:119–128. doi: 10.1289/ehp.7201119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lorr N. A., Golemboski K. A., Hemendinger R. A., Dietert R. R., Bloom S. E. Distribution and inducibility of a P450I activity in cellular components of the avian immune system. Arch Toxicol. 1992;66(8):560–566. doi: 10.1007/BF01973386. [DOI] [PubMed] [Google Scholar]
  10. Lucier G. W., McDaniel O. S., Hook G. E. Nature of the enhancement of hepatic uridine diphosphate glucuronyltransferase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Biochem Pharmacol. 1975 Feb 1;24(3):325–334. doi: 10.1016/0006-2952(75)90213-0. [DOI] [PubMed] [Google Scholar]
  11. Lü Y. C., Wu Y. C. Clinical findings and immunological abnormalities in Yu-Cheng patients. Environ Health Perspect. 1985 Feb;59:17–29. doi: 10.1289/ehp.59-1568085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Murai K., Okamura K., Tsuji H., Kajiwara E., Watanabe H., Akagi K., Fujishima M. Thyroid function in "yusho" patients exposed to polychlorinated biphenyls (PCB). Environ Res. 1987 Dec;44(2):179–187. doi: 10.1016/s0013-9351(87)80226-8. [DOI] [PubMed] [Google Scholar]
  13. Nakayama J., Hori Y., Toshitani S., Asahi M. [Dermatological findings in the annual examination of the patients with Yusho in 1995-1996]. Fukuoka Igaku Zasshi. 1997 May;88(5):236–239. [PubMed] [Google Scholar]
  14. Pesatori A. C., Zocchetti C., Guercilena S., Consonni D., Turrini D., Bertazzi P. A. Dioxin exposure and non-malignant health effects: a mortality study. Occup Environ Med. 1998 Feb;55(2):126–131. doi: 10.1136/oem.55.2.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Puhvel S. M., Sakamoto M. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine skin. J Invest Dermatol. 1988 Mar;90(3):354–358. doi: 10.1111/1523-1747.ep12456367. [DOI] [PubMed] [Google Scholar]
  16. Rogan W. J., Gladen B. C., Hung K. L., Koong S. L., Shih L. Y., Taylor J. S., Wu Y. C., Yang D., Ragan N. B., Hsu C. C. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science. 1988 Jul 15;241(4863):334–336. doi: 10.1126/science.3133768. [DOI] [PubMed] [Google Scholar]
  17. Vos J. G., Moore J. A., Zinkl J. G. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ Health Perspect. 1973 Sep;5:149–162. doi: 10.1289/ehp.7305149. [DOI] [PMC free article] [PubMed] [Google Scholar]

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