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. 1999 Sep;107(9):731–744. doi: 10.1289/ehp.99107731

Chronic beryllium disease and cancer risk estimates with uncertainty for beryllium released to the air from the Rocky Flats Plant.

P D McGavran 1, A S Rood 1, J E Till 1
PMCID: PMC1566450  PMID: 10464074

Abstract

Beryllium was released into the air from routine operations and three accidental fires at the Rocky Flats Plant (RFP) in Colorado from 1958 to 1989. We evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer risks and risks of chronic beryllium disease to hypothetical receptors. This article discusses exposure-response relationships for lung cancer and chronic beryllium disease. We assigned a distribution to cancer slope factor values based on the relative risk estimates from an occupational epidemiologic study used by the U.S. Environmental Protection Agency (EPA) to determine the slope factors. We used the regional atmospheric transport code for Hanford emission tracking atmospheric transport model for exposure calculations because it is particularly well suited for long-term annual-average dispersion estimates and it incorporates spatially varying meteorologic and environmental parameters. We accounted for model prediction uncertainty by using several multiplicative stochastic correction factors that accounted for uncertainty in the dispersion estimate, the meteorology, deposition, and plume depletion. We used Monte Carlo techniques to propagate model prediction uncertainty through to the final risk calculations. We developed nine exposure scenarios of hypothetical but typical residents of the RFP area to consider the lifestyle, time spent outdoors, location, age, and sex of people who may have been exposed. We determined geometric mean incremental lifetime cancer incidence risk estimates for beryllium inhalation for each scenario. The risk estimates were < 10(-6). Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aller A. J. The clinical significance of beryllium. J Trace Elem Electrolytes Health Dis. 1990 Mar;4(1):1–6. [PubMed] [Google Scholar]
  2. Brosi R., Gröning K., Behrens S. E., Lührmann R., Krämer A. Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9. Science. 1993 Oct 1;262(5130):102–105. doi: 10.1126/science.8211112. [DOI] [PubMed] [Google Scholar]
  3. Deodhar S. D., Barna B. P. Immune mechanisms in beryllium lung disease. Cleve Clin J Med. 1991 Mar-Apr;58(2):157–160. doi: 10.3949/ccjm.58.2.157. [DOI] [PubMed] [Google Scholar]
  4. Eisenbud M., Lisson J. Epidemiological aspects of beryllium-induced nonmalignant lung disease: a 30-year update. J Occup Med. 1983 Mar;25(3):196–202. doi: 10.1097/00043764-198303000-00012. [DOI] [PubMed] [Google Scholar]
  5. Hardy H. L. Beryllium disease: a clinical perspective. Environ Res. 1980 Feb;21(1):1–9. doi: 10.1016/0013-9351(80)90002-x. [DOI] [PubMed] [Google Scholar]
  6. Hasan F. M., Kazemi H. Chronic beryllium disease: a continuing epidemiologic hazard. Chest. 1974 Mar;65(3):289–293. doi: 10.1378/chest.65.3.289. [DOI] [PubMed] [Google Scholar]
  7. Kreiss K., Mroz M. M., Newman L. S., Martyny J., Zhen B. Machining risk of beryllium disease and sensitization with median exposures below 2 micrograms/m3. Am J Ind Med. 1996 Jul;30(1):16–25. doi: 10.1002/(SICI)1097-0274(199607)30:1<16::AID-AJIM3>3.0.CO;2-Q. [DOI] [PubMed] [Google Scholar]
  8. Kreiss K., Mroz M. M., Zhen B., Martyny J. W., Newman L. S. Epidemiology of beryllium sensitization and disease in nuclear workers. Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):985–991. doi: 10.1164/ajrccm/148.4_Pt_1.985. [DOI] [PubMed] [Google Scholar]
  9. Kreiss K., Wasserman S., Mroz M. M., Newman L. S. Beryllium disease screening in the ceramics industry. Blood lymphocyte test performance and exposure-disease relations. J Occup Med. 1993 Mar;35(3):267–274. [PubMed] [Google Scholar]
  10. Lang L. Beryllium: A Chronic Problem. Environ Health Perspect. 1994 Jun;102(6-7):526–531. doi: 10.1289/ehp.94102526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Layton D. W. Metabolically consistent breathing rates for use in dose assessments. Health Phys. 1993 Jan;64(1):23–36. doi: 10.1097/00004032-199301000-00003. [DOI] [PubMed] [Google Scholar]
  12. Mancuso T. F. Mortality study of beryllium industry workers' occupational lung cancer. Environ Res. 1980 Feb;21(1):48–55. doi: 10.1016/0013-9351(80)90007-9. [DOI] [PubMed] [Google Scholar]
  13. Smith R. J. Beryllium report disputed by listed author. Science. 1981 Feb 6;211(4482):556–557. doi: 10.1126/science.211.4482.556. [DOI] [PubMed] [Google Scholar]
  14. Steenland K., Ward E. Lung cancer incidence among patients with beryllium disease: a cohort mortality study. J Natl Cancer Inst. 1991 Oct 2;83(19):1380–1385. doi: 10.1093/jnci/83.19.1380. [DOI] [PubMed] [Google Scholar]
  15. Wagoner J. K., Infante P. F., Bayliss D. L. Beryllium: an etiologic agent in the induction of lung cancer, nonneoplastic respiratory disease, and heart disease among industrially exposed workers. Environ Res. 1980 Feb;21(1):15–34. doi: 10.1016/0013-9351(80)90004-3. [DOI] [PubMed] [Google Scholar]
  16. Ward E., Okun A., Ruder A., Fingerhut M., Steenland K. A mortality study of workers at seven beryllium processing plants. Am J Ind Med. 1992;22(6):885–904. doi: 10.1002/ajim.4700220610. [DOI] [PubMed] [Google Scholar]

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