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. 1999 Aug;107(8):649–656. doi: 10.1289/ehp.99107649

Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages.

D B Richardson 1, S Wing 1
PMCID: PMC1566496  PMID: 10417363

Abstract

We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-level exposure to external ionizing radiation and mortality. These associations were larger for doses received after 45 years of age, larger under longer lag assumptions, and primarily due to cancer causes of death. All cancer mortality was estimated to increase 4.98% [standard error (SE) = 1.5] per 10-mSv cumulative dose received after age 45 under a 10-year lag, and 7.31% (SE = 2.2) per 10-mSv cumulative dose received after age 45 under a 20-year lag. Associations between radiation dose and lung cancer were of similar magnitude to associations between radiation dose and all cancers except lung cancer. Nonmalignant respiratory disease exhibited a positive association with cumulative radiation dose received after age 45, whereas ischemic heart disease exhibited no association with radiation dose. These findings suggest increases in cancer mortality associated with low-level external exposure to ionizing radiation and potentially greater sensitivity to the carcinogenic effects of ionizing radiation with older ages at exposure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arrighi H. M., Hertz-Picciotto I. The evolving concept of the healthy worker survivor effect. Epidemiology. 1994 Mar;5(2):189–196. doi: 10.1097/00001648-199403000-00009. [DOI] [PubMed] [Google Scholar]
  2. Axelson O. Confounding from smoking in occupational epidemiology. Br J Ind Med. 1989 Aug;46(8):505–507. doi: 10.1136/oem.46.8.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Axelson O., Steenland K. Indirect methods of assessing the effects of tobacco use in occupational studies. Am J Ind Med. 1988;13(1):105–118. doi: 10.1002/ajim.4700130107. [DOI] [PubMed] [Google Scholar]
  4. Boice J. D., Jr, Preston D., Davis F. G., Monson R. R. Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiat Res. 1991 Feb;125(2):214–222. [PubMed] [Google Scholar]
  5. Charlton B. G. Senescence, cancer and 'endogenous parasites': a salutogenic hypothesis. J R Coll Physicians Lond. 1996 Jan-Feb;30(1):10–12. [PMC free article] [PubMed] [Google Scholar]
  6. Checkoway H., Mathew R. M., Shy C. M., Watson J. E., Jr, Tankersley W. G., Wolf S. H., Smith J. C., Fry S. A. Radiation, work experience, and cause specific mortality among workers at an energy research laboratory. Br J Ind Med. 1985 Aug;42(8):525–533. doi: 10.1136/oem.42.8.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cohen H. J. Biology of aging as related to cancer. Cancer. 1994 Oct 1;74(7 Suppl):2092–2100. doi: 10.1002/1097-0142(19941001)74:7+<2092::aid-cncr2820741717>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  8. Crump K. S., Allen B. C., Howe R. B., Crockett P. W. Time-related factors in quantitative risk assessment. J Chronic Dis. 1987;40 (Suppl 2):101S–111S. doi: 10.1016/s0021-9681(87)80013-9. [DOI] [PubMed] [Google Scholar]
  9. Direct estimates of cancer mortality due to low doses of ionising radiation: an international study. IARC Study Group on Cancer Risk among Nuclear Industry Workers. Lancet. 1994 Oct 15;344(8929):1039–1043. [PubMed] [Google Scholar]
  10. Dupree E. A., Watkins J. P., Ingle J. N., Wallace P. W., West C. M., Tankersley W. G. Uranium dust exposure and lung cancer risk in four uranium processing operations. Epidemiology. 1995 Jul;6(4):370–375. doi: 10.1097/00001648-199507000-00007. [DOI] [PubMed] [Google Scholar]
  11. Fabrikant J. I. Factors that modify risks of radiation-induced cancer. Health Phys. 1990 Jul;59(1):77–87. doi: 10.1097/00004032-199007000-00009. [DOI] [PubMed] [Google Scholar]
  12. Frome E. L., Cragle D. L., Watkins J. P., Wing S., Shy C. M., Tankersley W. G., West C. M. A mortality study of employees of the nuclear industry in Oak Ridge, Tennessee. Radiat Res. 1997 Jul;148(1):64–80. [PubMed] [Google Scholar]
  13. Gilbert E. S., Cragle D. L., Wiggs L. D. Updated analyses of combined mortality data for workers at the Hanford Site, Oak Ridge National Laboratory, and Rocky Flats Weapons Plant. Radiat Res. 1993 Dec;136(3):408–421. [PubMed] [Google Scholar]
  14. Gilbert E. S. Mortality of workers at the Oak Ridge National Laboratory. Health Phys. 1992 Mar;62(3):260–264. [PubMed] [Google Scholar]
  15. Järvholm B. Dose-response in epidemiology--age and time aspects. Am J Ind Med. 1992;21(1):101–106. doi: 10.1002/ajim.4700210112. [DOI] [PubMed] [Google Scholar]
  16. Kerr G. D. Missing dose from mortality studies of radiation effects among workers at Oak Ridge National Laboratory. Health Phys. 1994 Feb;66(2):206–208. doi: 10.1097/00004032-199402000-00012. [DOI] [PubMed] [Google Scholar]
  17. Kneale G. W., Stewart A. M. Factors affecting recognition of cancer risks of nuclear workers. Occup Environ Med. 1995 Aug;52(8):515–523. doi: 10.1136/oem.52.8.515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Narayanan S. Laboratory markers as an index of aging. Ann Clin Lab Sci. 1996 Jan-Feb;26(1):50–59. [PubMed] [Google Scholar]
  19. Pearce N., Checkoway H., Shy C. Time-related factors as potential confounders and effect modifiers in studies based on an occupational cohort. Scand J Work Environ Health. 1986 Apr;12(2):97–107. doi: 10.5271/sjweh.2161. [DOI] [PubMed] [Google Scholar]
  20. Petersen G. R., Gilbert E. S., Buchanan J. A., Stevens R. G. A case-cohort study of lung cancer, ionizing radiation, and tobacco smoking among males at the Hanford Site. Health Phys. 1990 Jan;58(1):3–11. doi: 10.1097/00004032-199001000-00001. [DOI] [PubMed] [Google Scholar]
  21. Preston D. L., Kusumi S., Tomonaga M., Izumi S., Ron E., Kuramoto A., Kamada N., Dohy H., Matsuo T., Matsui T [corrected to Matsuo T. ]. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res. 1994 Feb;137(2 Suppl):S68–S97. [PubMed] [Google Scholar]
  22. Richardson D. B., Wing S. Methods for investigating age differences in the effects of prolonged exposures. Am J Ind Med. 1998 Feb;33(2):123–130. doi: 10.1002/(sici)1097-0274(199802)33:2<123::aid-ajim4>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  23. Ron E., Carter R., Jablon S., Mabuchi K. Agreement between death certificate and autopsy diagnoses among atomic bomb survivors. Epidemiology. 1994 Jan;5(1):48–56. doi: 10.1097/00001648-199401000-00009. [DOI] [PubMed] [Google Scholar]
  24. Rose G. Environmental health: problems and prospects. J R Coll Physicians Lond. 1991 Jan;25(1):48–52. [PMC free article] [PubMed] [Google Scholar]
  25. Siemiatycki J., Krewski D., Franco E., Kaiserman M. Associations between cigarette smoking and each of 21 types of cancer: a multi-site case-control study. Int J Epidemiol. 1995 Jun;24(3):504–514. doi: 10.1093/ije/24.3.504. [DOI] [PubMed] [Google Scholar]
  26. Siemiatycki J., Wacholder S., Dewar R., Cardis E., Greenwood C., Richardson L. Degree of confounding bias related to smoking, ethnic group, and socioeconomic status in estimates of the associations between occupation and cancer. J Occup Med. 1988 Aug;30(8):617–625. doi: 10.1097/00043764-198808000-00004. [DOI] [PubMed] [Google Scholar]
  27. Siemiatycki J., Wacholder S., Dewar R., Wald L., Bégin D., Richardson L., Rosenman K., Gérin M. Smoking and degree of occupational exposure: are internal analyses in cohort studies likely to be confounded by smoking status? Am J Ind Med. 1988;13(1):59–69. doi: 10.1002/ajim.4700130105. [DOI] [PubMed] [Google Scholar]
  28. Steenland K., Beaumont J., Halperin W. Methods of control for smoking in occupational cohort mortality studies. Scand J Work Environ Health. 1984 Jun;10(3):143–149. doi: 10.5271/sjweh.2349. [DOI] [PubMed] [Google Scholar]
  29. Steenland K., Deddens J., Salvan A., Stayner L. Negative bias in exposure-response trends in occupational studies: modeling the healthy workers survivor effect. Am J Epidemiol. 1996 Jan 15;143(2):202–210. doi: 10.1093/oxfordjournals.aje.a008730. [DOI] [PubMed] [Google Scholar]
  30. Steenland K., Stayner L. The importance of employment status in occupational cohort mortality studies. Epidemiology. 1991 Nov;2(6):418–423. doi: 10.1097/00001648-199111000-00005. [DOI] [PubMed] [Google Scholar]
  31. Stewart A. M., Kneale G. W. A-bomb radiation and evidence of late effects other than cancer. Health Phys. 1990 Jun;58(6):729–735. doi: 10.1097/00004032-199006000-00004. [DOI] [PubMed] [Google Scholar]
  32. Stewart A. M., Kneale G. W. A-bomb survivors: further evidence of late effects of early deaths. Health Phys. 1993 May;64(5):467–472. doi: 10.1097/00004032-199305000-00002. [DOI] [PubMed] [Google Scholar]
  33. Stewart A. M., Kneale G. W. Late effects of A-bomb radiation: risk problems unrelated to the new dosimetry. Health Phys. 1988 May;54(5):567–569. [PubMed] [Google Scholar]
  34. Stewart A. M., Kneale G. W. Relations between age at occupational exposure to ionising radiation and cancer risk. Occup Environ Med. 1996 Apr;53(4):225–230. doi: 10.1136/oem.53.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Stockwell H. G., Brooks B. G., Holmes H. H., Durst M. J., Shim Y. K., Heinig P. E. The Department of Energy's Comprehensive Epidemiologic Data Resource: a public-use database on radiation exposure. Am J Public Health. 1996 May;86(5):747–748. doi: 10.2105/ajph.86.5.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Thompson D. E., Mabuchi K., Ron E., Soda M., Tokunaga M., Ochikubo S., Sugimoto S., Ikeda T., Terasaki M., Izumi S. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiat Res. 1994 Feb;137(2 Suppl):S17–S67. [PubMed] [Google Scholar]
  37. Watson J. E., Jr, Wood J. L., Tankersley W. G., West C. M. Estimation of radiation doses for workers without monitoring data for retrospective epidemiologic studies. Health Phys. 1994 Oct;67(4):402–405. doi: 10.1097/00004032-199410000-00012. [DOI] [PubMed] [Google Scholar]
  38. Wilkinson G. S. Epidemiologic studies of nuclear and radiation workers: an overview of what is known about health risks posed by the nuclear industry. Occup Med. 1991 Oct-Dec;6(4):715–724. [PubMed] [Google Scholar]
  39. Wing S., Shy C. M., Wood J. L., Wolf S., Cragle D. L., Frome E. L. Mortality among workers at Oak Ridge National Laboratory. Evidence of radiation effects in follow-up through 1984. JAMA. 1991 Mar 20;265(11):1397–1402. [PubMed] [Google Scholar]
  40. Wing S., Shy C. M., Wood J. L., Wolf S., Cragle D. L., Tankersley W., Frome E. L. Job factors, radiation and cancer mortality at Oak Ridge National Laboratory: follow-up through 1984. Am J Ind Med. 1993 Feb;23(2):265–279. doi: 10.1002/ajim.4700230204. [DOI] [PubMed] [Google Scholar]
  41. Wing S., West C. M., Wood J. L., Tankersley W. Recording of external radiation exposures at Oak Ridge National Laboratory: implications for epidemiological studies. J Expo Anal Environ Epidemiol. 1994 Jan-Mar;4(1):83–93. [PubMed] [Google Scholar]
  42. Wood J., Richardson D., Wing S. A simple program to create exact person-time data in cohort analyses. Int J Epidemiol. 1997 Apr;26(2):395–399. doi: 10.1093/ije/26.2.395. [DOI] [PubMed] [Google Scholar]

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