Skip to main content
NCBI home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1999 Jun;107(6):423–427. doi: 10.1289/ehp.99107423

Chemical wastes, children's health, and the Superfund Basic Research Program.

P J Landrigan 1, W A Suk 1, R W Amler 1
PMCID: PMC1566589  PMID: 10339440

Abstract

Three to 4 million children and adolescents in the United States live within 1 mile of a federally designated Superfund hazardous waste disposal site and are at risk of exposure to chemical toxicants released from these sites into air, groundwater, surface water, and surrounding communities. Because of their patterns of exposure and their biological vulnerability, children are uniquely susceptible to health injury resulting from exposures to chemical toxicants in the environment. The Superfund Basic Research Program, funded by the U.S. Environmental Protection Agency and directed by the National Institute of Environmental Health Sciences, is extremely well positioned to organize multidisciplinary research that will assess patterns of children's exposures to hazardous chemicals from hazardous waste disposal sites; quantify children's vulnerability to environmental toxicants; assess causal associations between environmental exposures and pediatric disease; and elucidate the mechanisms of environmental disease in children at the cellular and molecular level.

Full text

PDF
423

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellinger D., Leviton A., Waternaux C., Needleman H., Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med. 1987 Apr 23;316(17):1037–1043. doi: 10.1056/NEJM198704233161701. [DOI] [PubMed] [Google Scholar]
  2. Bullard R. D. Solid waste sites and the black Houston community. Sociol Inq. 1983;53(2-3):273–288. doi: 10.1111/j.1475-682x.1983.tb00037.x. [DOI] [PubMed] [Google Scholar]
  3. Campbell C. G., Seidler F. J., Slotkin T. A. Chlorpyrifos interferes with cell development in rat brain regions. Brain Res Bull. 1997;43(2):179–189. doi: 10.1016/s0361-9230(96)00436-4. [DOI] [PubMed] [Google Scholar]
  4. Chanda S. M., Pope C. N. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol Biochem Behav. 1996 Apr;53(4):771–776. doi: 10.1016/0091-3057(95)02105-1. [DOI] [PubMed] [Google Scholar]
  5. Devesa S. S., Blot W. J., Stone B. J., Miller B. A., Tarone R. E., Fraumeni J. F., Jr Recent cancer trends in the United States. J Natl Cancer Inst. 1995 Feb 1;87(3):175–182. doi: 10.1093/jnci/87.3.175. [DOI] [PubMed] [Google Scholar]
  6. Dockery D. W., Pope C. A., 3rd Acute respiratory effects of particulate air pollution. Annu Rev Public Health. 1994;15:107–132. doi: 10.1146/annurev.pu.15.050194.000543. [DOI] [PubMed] [Google Scholar]
  7. Ecobichon D. J., Stephens D. S. Perinatal development of human blood esterases. Clin Pharmacol Ther. 1973 Jan-Feb;14(1):41–47. doi: 10.1002/cpt197314141. [DOI] [PubMed] [Google Scholar]
  8. Ekbom A., Hsieh C. C., Lipworth L., Adami H. Q., Trichopoulos D. Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997 Jan 1;89(1):71–76. doi: 10.1093/jnci/89.1.71. [DOI] [PubMed] [Google Scholar]
  9. Gray R., Peto R., Brantom P., Grasso P. Chronic nitrosamine ingestion in 1040 rodents: the effect of the choice of nitrosamine, the species studied, and the age of starting exposure. Cancer Res. 1991 Dec 1;51(23 Pt 2):6470–6491. [PubMed] [Google Scholar]
  10. Jacobson J. L., Jacobson S. W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783–789. doi: 10.1056/NEJM199609123351104. [DOI] [PubMed] [Google Scholar]
  11. Landrigan P. J., Carlson J. E., Bearer C. F., Cranmer J. S., Bullard R. D., Etzel R. A., Groopman J., McLachlan J. A., Perera F. P., Reigart J. R. Children's health and the environment: a new agenda for prevention research. Environ Health Perspect. 1998 Jun;106 (Suppl 3):787–794. doi: 10.1289/ehp.98106787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Landrigan P. J. Commentary: environmental disease--a preventable epidemic. Am J Public Health. 1992 Jul;82(7):941–943. doi: 10.2105/ajph.82.7.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lee P., Paxman D. Reinventing public health. Annu Rev Public Health. 1997;18:1–35. doi: 10.1146/annurev.publhealth.18.1.1. [DOI] [PubMed] [Google Scholar]
  14. Longnecker M. P., Rogan W. J., Lucier G. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health. 1997;18:211–244. doi: 10.1146/annurev.publhealth.18.1.211. [DOI] [PubMed] [Google Scholar]
  15. Needleman H. L., Schell A., Bellinger D., Leviton A., Allred E. N. The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med. 1990 Jan 11;322(2):83–88. doi: 10.1056/NEJM199001113220203. [DOI] [PubMed] [Google Scholar]
  16. Paulozzi L. J., Erickson J. D., Jackson R. J. Hypospadias trends in two US surveillance systems. Pediatrics. 1997 Nov;100(5):831–834. doi: 10.1542/peds.100.5.831. [DOI] [PubMed] [Google Scholar]
  17. Robison L. L., Buckley J. D., Bunin G. Assessment of environmental and genetic factors in the etiology of childhood cancers: the Childrens Cancer Group epidemiology program. Environ Health Perspect. 1995 Sep;103 (Suppl 6):111–116. doi: 10.1289/ehp.95103s6111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Song X., Seidler F. J., Saleh J. L., Zhang J., Padilla S., Slotkin T. A. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol Appl Pharmacol. 1997 Jul;145(1):158–174. doi: 10.1006/taap.1997.8171. [DOI] [PubMed] [Google Scholar]
  19. Stewart A., Kneale G. W. Radiation dose effects in relation to obstetric x-rays and childhood cancers. Lancet. 1970 Jun 6;1(7658):1185–1188. doi: 10.1016/s0140-6736(70)91782-4. [DOI] [PubMed] [Google Scholar]
  20. Whitney K. D., Seidler F. J., Slotkin T. A. Developmental neurotoxicity of chlorpyrifos: cellular mechanisms. Toxicol Appl Pharmacol. 1995 Sep;134(1):53–62. doi: 10.1006/taap.1995.1168. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES