Abstract
Toxicity and potential carcinogenicity studies of boric acid were investigated in mice to verify in a second rodent species that this was a noncarcinogenic chemical. Earlier chronic studies in rats indicated boric acid was not a carcinogen. The chemical is nominated for testing because over 200 tons are produced annually, there are multiple uses for the product, and there is potential for widespread human exposure, both orally and dermally. Both sexes of B6C3F1 mice were offered diets mixed with boric acid for 14 days, 13 weeks, or 2 years. Dietary doses used in the acute, 14-day study were 0, 0.62, 1.25, 2.5, 5, and 10%; those in the subchronic, 13-week study were 0, 0.12, 0.25, 0.50, 1, and 2%; and doses in the 2-year, chronic study were 0, 0.25, and 0.50% in the diet. Mortality, clinical signs of toxicity, estimates of food consumption, body weight gain, and histopathologic examination of selected tissues constituted the variables measured. In the 14-day study mortality was proportional to dose and time of exposure in both sexes, occurring in dose groups as low as 2.5% and as early as 7 days of exposure. Body weights were depressed more than 10% below controls in the higher dose groups of both sexes. Mortality in the 13-week study was confined to the two highest dose groups in male mice and to the 2%-dose group in females. Body weight depression from 8 to 23% below those of controls occurred in the 0.50% and higher dose groups of both sexes.(ABSTRACT TRUNCATED AT 250 WORDS)
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- DRAIZE J. H., KELLEY E. A. The urinary excretion of boric acid preparations following oral administration and topical applications to intact and damaged skin of rabbits. Toxicology. 1959 May;1(3):267–276. doi: 10.1016/0041-008x(59)90111-5. [DOI] [PubMed] [Google Scholar]
- GOLDBLOOM R. B., GOLDBLOOM A. Boric acid poisoning; report of four cases and a review of 109 cases from the world literature. J Pediatr. 1953 Dec;43(6):631–643. doi: 10.1016/s0022-3476(53)80304-5. [DOI] [PubMed] [Google Scholar]
- Haseman J. K. Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies. Environ Health Perspect. 1984 Dec;58:385–392. doi: 10.1289/ehp.8458385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haworth S., Lawlor T., Mortelmans K., Speck W., Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 (Suppl 1):1–142. [PubMed] [Google Scholar]
- Krasovskii G. N., Varshavskaya S. P., Borisov A. I. Toxic and gonadotropic effects of cadmium and boron relative to standards for these substances in drinking water. Environ Health Perspect. 1976 Feb;13:69–75. doi: 10.1289/ehp.761369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MULINOS M. G., CONNANT C., HAUSER E. The toxicity of boric acid and the clinical implications of the use of borated baby powders. Bulletin NY Med Coll. 1953;16:92–101. [PubMed] [Google Scholar]
- Schuppli R., Seiler H., Schneeberger R., Niggli H., Hoffmann K. Uber die Toxizität der Borsäure. Dermatologica. 1971;143(4):227–234. [PubMed] [Google Scholar]
- Swate T. E., Weed J. C. Boric acid treatment of vulvovaginal candidiasis. Obstet Gynecol. 1974 Jun;43(6):893–895. [PubMed] [Google Scholar]
- VIGNEC A. J., ELLIS R. Inabsorbability of boric acid in infant powder. AMA Am J Dis Child. 1954 Jul;88(1):72–80. doi: 10.1001/archpedi.1954.02050100074009. [DOI] [PubMed] [Google Scholar]
- Weir R. J., Jr, Fisher R. S. Toxicologic studies on borax and boric acid. Toxicol Appl Pharmacol. 1972 Nov;23(3):351–364. doi: 10.1016/0041-008x(72)90037-3. [DOI] [PubMed] [Google Scholar]