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. 1994 Oct;102(10):852–853. doi: 10.1289/ehp.94102852

The cytochromes P450 and mechanisms of chemical carcinogenesis.

D V Parke 1
PMCID: PMC1567360  PMID: 9644192

Abstract

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.

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Selected References

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