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. 1994 Sep;102(Suppl 3):17–20. doi: 10.1289/ehp.94102s317

Active oxygen species in DNA damage induced by carcinogenic metal compounds.

S Kawanishi 1, S Inoue 1, K Yamamoto 1
PMCID: PMC1567415  PMID: 7843093

Abstract

Some carcinogenic metal compounds [chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), and nickel(II)[ induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage; 8-hydroxyl-2'-deoxyguanosine formation is included in the DNA damage. Using pulsed-field gel electrophoresis, nickel sulfide was shown to induce oxidative DNA cleavage in cultured cells. On the basis of these findings, we have emphasized the role of oxygen radicals in metal carcinogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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