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. 1990 Aug;88:237–241. doi: 10.1289/ehp.9088237

Induction and progression of human lymphoproliferative lesions by Epstein-Barr virus.

B B Chappuis 1, H K Müller-Hermelink 1
PMCID: PMC1568009  PMID: 2176977

Abstract

Epstein-Barr virus (EBV) is involved in numerous lymphoproliferative diseases. In addition to classical lesions such as endemic Burkitt's lymphoma and infectious mononucleosis, there are other disorders of the lymphoid system that are discussed in relation to EBV: B-cell lymphomas in immunosuppressed individuals. Hodgkin's disease and, to some extent, primary extranodal lymphomas. Studies of the EBV expression in classical and nonclassical lesions could lead to the better understanding of different EBV mechanisms in lymphomagenesis.

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Selected References

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  1. Fingeroth J. D., Weis J. J., Tedder T. F., Strominger J. L., Biro P. A., Fearon D. T. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4510–4514. doi: 10.1073/pnas.81.14.4510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Fox R. I., Pearson G., Vaughan J. H. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjogren's syndrome. J Immunol. 1986 Nov 15;137(10):3162–3168. [PubMed] [Google Scholar]
  3. Frizzera G., Hanto D. W., Gajl-Peczalska K. J., Rosai J., McKenna R. W., Sibley R. K., Holahan K. P., Lindquist L. L. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res. 1981 Nov;41(11 Pt 1):4262–4279. [PubMed] [Google Scholar]
  4. Goelz S. E., Hamilton S. R., Vogelstein B. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun. 1985 Jul 16;130(1):118–126. doi: 10.1016/0006-291x(85)90390-0. [DOI] [PubMed] [Google Scholar]
  5. Isaacson P., Wright D. H. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983 Oct 15;52(8):1410–1416. doi: 10.1002/1097-0142(19831015)52:8<1410::aid-cncr2820520813>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  6. Jones J. F., Shurin S., Abramowsky C., Tubbs R. R., Sciotto C. G., Wahl R., Sands J., Gottman D., Katz B. Z., Sklar J. T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N Engl J Med. 1988 Mar 24;318(12):733–741. doi: 10.1056/NEJM198803243181203. [DOI] [PubMed] [Google Scholar]
  7. Klein G., Svedmyr E., Jondal M., Persson P. O. EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients. Int J Cancer. 1976 Jan 15;17(1):21–26. doi: 10.1002/ijc.2910170105. [DOI] [PubMed] [Google Scholar]
  8. Klein G. Viral latency and transformation: the strategy of Epstein-Barr virus. Cell. 1989 Jul 14;58(1):5–8. doi: 10.1016/0092-8674(89)90394-2. [DOI] [PubMed] [Google Scholar]
  9. Kornstein M. J., Weber J., Luck J. B., Massey G. V., Strom S., McWilliams N. B. Epstein-Barr virus-associated lymphoproliferative disorder. Applications of immunoperoxidase and molecular biologic techniques. Arch Pathol Lab Med. 1989 May;113(5):481–484. [PubMed] [Google Scholar]
  10. Purtilo D. T., Okano M., Grierson H. L. Immune deficiency as a risk factor in Epstein-Barr virus-induced malignant diseases. Environ Health Perspect. 1990 Aug;88:225–230. doi: 10.1289/ehp.9088225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Saito I., Servenius B., Compton T., Fox R. I. Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J Exp Med. 1989 Jun 1;169(6):2191–2198. doi: 10.1084/jem.169.6.2191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stevenson M., Volsky B., Hedenskog M., Volsky D. J. Immortalization of human T lymphocytes after transfection of Epstein-Barr virus DNA. Science. 1986 Aug 29;233(4767):980–984. doi: 10.1126/science.3016899. [DOI] [PubMed] [Google Scholar]
  13. Virelizier J. L., Lenoir G., Griscelli C. Persistent Epstein-Barr virus infection in a child with hypergammaglobulinaemia and immunoblastic proliferation associated with a selective defect in immune interferon secretion. Lancet. 1978 Jul 29;2(8083):231–234. doi: 10.1016/s0140-6736(78)91744-0. [DOI] [PubMed] [Google Scholar]
  14. Weiss L. M., Strickler J. G., Warnke R. A., Purtilo D. T., Sklar J. Epstein-Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol. 1987 Oct;129(1):86–91. [PMC free article] [PubMed] [Google Scholar]
  15. Ziegler J. L., Magrath I. T., Gerber P., Levine P. H. Epstein-Barr virus and human malignancy. Ann Intern Med. 1977 Mar;86(3):323–336. doi: 10.7326/0003-4819-86-3-323. [DOI] [PubMed] [Google Scholar]

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