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. 1991 Jun;93:41–44. doi: 10.1289/ehp.919341

Genetic changes during mouse skin tumorigenesis.

P A Burns 1, R Bremner 1, A Balmain 1
PMCID: PMC1568051  PMID: 1685445

Abstract

This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrates that trisomy of chromosome 7 is an early event preceding papilloma formation, and further events, such as mitotic recombination, seem to occur during progression to malignant carcinomas. There is some evidence of a tumor-suppressor locus situated on chromosome 7.

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Selected References

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