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. 1984 Jun;56:23–34. doi: 10.1289/ehp.845623

Inhalation exposure methodology.

R F Phalen, R C Mannix, R T Drew
PMCID: PMC1568202  PMID: 6383799

Abstract

Modern man is being confronted with an ever-increasing inventory of potentially toxic airborne substances. Exposures to these atmospheric contaminants occur in residential and commercial settings, as well as in the workplace. In order to study the toxicity of such materials, a special technology relating to inhalation exposure systems has evolved. The purpose of this paper is to provide a description of the techniques which are used in exposing laboratory subjects to airborne particles and gases. The various modes of inhalation exposure (whole body, head only, nose or mouth only, etc.) are described at length, including the advantages and disadvantages inherent to each mode. Numerous literature citations are included for further reading. Among the topics briefly discussed are the selection of appropriate animal species for toxicological testing, and the types of inhalation studies performed (acute, chronic, etc.).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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